Comparison of invasive and noninvasive measurements of indocyanine green plasma disappearance rate in critically ill patients with mechanical ventilation and stable hemodynamics
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Objectives: We studied the correlation between invasive (aortic fiberoptic) and noninvasive (transcutaneous sensor) measurements of indocyanine green (ICG) plasma disappearance rate (PDR) in critically ill patients.
Design and setting: Prospective clinical study in a surgical intensive care unit of a university hospital.
Patients: 16 critically ill patients with adult respiratory distress syndrome (n=8), sepsis/septic shock (n=6), subarachnoid hemorrhage (n=1), or severe head injury (n=1).
Measurements and results: We analyzed 16 pairs of simultaneous ICG PDR measurements. All patients were deeply sedated and mechanically ventilated. Each patient received a 4-F aortic catheter with an integrated fiberoptic and thermistor connected to a computer system for automatic calculation of invasive ICG PDR (PDRINV). An ICG sensor was also attached to the nose wing and connected to a DDG2001 analyzer for noninvasive measurement (PDRNINV). Linear regression analysis revealed PDRNINV=0.98 PDRINV+0.11%/min (r=0.94, p<0.0001) with a mean bias of 0.2±2.0%/min.
Conclusion: Noninvasive measurements of ICG PDR are very highly correlated with values derived from an invasive fiberoptic-based reference technique.
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