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Intensive Care Medicine

, Volume 26, Issue 10, pp 1512–1514 | Cite as

Is leukocytosis a predictor of mortality in severe pertussis infection?

  • Christine Pierce
  • Nigel Klein
  • Mark Peters
Neonatal and Pediatric Intensive Care

Abstract

Bordetella pertussis causing severe respiratory failure in infants that is unresponsive to treatment is well described. Pulmonary hypertension is a prominent feature of such cases. In this series of 13 critically ill infants with B. pertussis, hyperleukocytosis (>100×109/l) was an independent predictor of death. We suggest that such extreme leukocytosis may contribute to disease severity via the formation of aggregates in the pulmonary vasculature.

Pertussis Whooping cough Respiratory failure Pulmonary hypertension Outcome Leukocytosis 

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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Christine Pierce
    • 1
  • Nigel Klein
    • 2
  • Mark Peters
    • 3
  1. 1.Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London, WC1N 3JHof Child Health, Guilford Street, London WC1N 3EH, UKUK
  2. 2.Immunobiology Unit, Institute of Child Health, Guilford Street, London WC1N 3EH, UKUK
  3. 3.Portex Department of Anaesthesia, Intensive Therapy and Respiratory Medicine, Institute of Child Health, Guilford Street, London, WC1N 3EH, UKUK

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