Leptospirosis: one of the forgotten diseases
“On a strange, acute infectious disease, accompanied by swelling of the spleen, icterus, and nephritis” Adolf Weil (1886)
Leptospirosis is a zoonosis with a worldwide distribution affecting in particular countries with tropical and subtropical climates. Even before the first description of leptospirosis by Adolf Weil in 1886, the disease was well known in different parts of the world frequently with names, some of which associated with agriculture or industrial activities . Leptospira, a corkscrew shaped bacterium, was first identified in 1907, but it was only in 1915 that this bacteria was recognized as the cause of this disease by Inada and Ido in Japan .
Leptospires are Gram-negative aerobic bacteria from the order Spirochaetales and the family Leptospiraceae, comprising 26 serogroups and more than 260 serovars . Although several mammals have been identified as potential reservoirs, the rats are the most significant one. The pathogenesis of the disease is poorly understood , but to develop leptospirosis the bacteria has to reach the host after contact or drinking contaminated water through small abrasions in the skin or the mucosa of the conjunctiva, oro and nasopharynx. Subsequently, it multiplies and grows spreading to virtually all organs causing a systemic infection. The disease is more frequent in tropical countries (10–100 per 100,000 inhabitants) compared to non-tropical areas (0.1–1 per 100,000 inhabitants). However, it is present in all continents with the exception of Antarctica [5, 6]. In Europe the number of reported cases was 1222 in 2015, that represents an increase in relation to the average reported cases in the 5 years before . However, climate change and global warming could alter this scenario in Europe with more favorable conditions of transmission. In addition, it is clear that leptospirosis is re-emerging in some countries .
Leptospirosis could present itself as a very severe disease, with multiple organ dysfunction with unusual clinical phenotypes (e.g. pulmonary failure with alveolar hemorrhage or marked jaundice without liver failure). Since in non-tropical areas it is an uncommon reason of hospital admission, clinicians often miss this diagnosis. Therefore, incidence in non-endemic areas is unknown and, more clinically relevant, misdiagnosis might occur. In this issue, Miailhe et al.  report the largest cohort of severe leptospirosis cases requiring intensive care unit (ICU) admission in a French multicenter cohort. During a 4-year period (2012–2016), 160 patients were retrospectively identified (0.04% of all ICU admissions). Overall hospital mortality was surprisingly low (9%) if one considers the severity-of-illness score (median SAPS II of 40) and the high prevalence of organ failures (SOFA of 11, more than half on vasoactive drugs, and at least one-third on invasive mechanical ventilation or renal replacement therapy). Multiple correspondence analysis and hierarchical classification on principal components identified four clinical phenotypes, with different prevalence and clinical presentations, and more relevant, contrasting demand for organ support therapies and mortality rates. Their phenotyping is mostly welcomed because it is based on clinical characteristics readily available and highlights the heterogeneity of this disease, and might help clinicians to raise clinical suspicious and pursuit proper microbiological diagnosis as well as initiate adequate antibiotic treatment empirically.
Since severe leptospirosis is a cause of sepsis (i.e. infection with organ dysfunction), lower availability of treatment resources are detrimental and unfortunately common in LMICs [10, 11]. The present study from Miailhe et al. reinforce that leptospirosis, albeit uncommon in some parts of the world, can have good outcomes if properly treated, but much worse outcomes in other areas with treatment resource limitations.
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Conflicts of interest
The authors declare that they have no conflict of interest.
- 6.World Health Organization. Leptospirosis Burden Epidemiology Reference Group (2019) http://www.whogis.com/zoonoses/diseases/lerg/en/index2.html Accessed 05 Oct 2019
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