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The comparison of Gram-positive and Gram-negative healthcare-associated ventriculitis and meningitis in adults and children

  • Thomas Rogers
  • Kevin Sok
  • Timothy Erickson
  • Elizabeth Aguilera
  • Susan H. Wootton
  • Kristy O. Murray
  • Rodrigo HasbunEmail author
Letter
  • 34 Downloads

Dear Editor,

Healthcare-associated ventriculitis and meningitis (HCAVM) is associated with adverse clinical outcomes in the majority of patients [1, 2, 3]. A recent study demonstrated that Gram-negative HCAVM had a higher mortality rate than Gram-positive [4]. The purpose of our study was to validate these findings and to compare clinical characteristics and outcomes between patients with Gram-positive and Gram-negative HCAVM.

We performed a retrospective analysis of patients diagnosed with HCAVM with a positive CSF Gram stain or culture at Texas Children’s Hospital (TCH) and Memorial Hermann Hospital (MHH) from December 2003 to January 2017. Baseline characteristics and laboratory chemistries were recorded at the time of CSF analysis. An adverse clinical outcome at discharge was defined as a Glasgow outcome scale 1–4 [3]. Drug resistance profiles were defined using the method from Magiorakos et al. [5].

During the study period, we identified 187 patients (93 adults and 94 children)...

Notes

Acknowledgements

We wish to thank the Grant A. Starr foundation for their research support.

Compliance with ethical standards

Conflicts of interest

RH has received research support and is a speaker for Biofire®. All other authors have no conflicts of interest relevant to this research.

References

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    Tunkel AR, Hasbun R, Bhimraj A et al (2017) Infectious diseases society of America’s clinical practice guidelines for healthcare-associated ventriculitis and meningitis. Clin Infect Dis 64(6):e34–e65CrossRefGoogle Scholar
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    Srihawan C, Castelblando RL, Salazar L et al (2016) Clinical characteristics and predictors of adverse outcome in adult and pediatric patients with healthcare-associated ventriculitis and meningitis. Open Forum Infect Dis 3(2):0fw077CrossRefGoogle Scholar
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    Kurtaran B, Kuscu F, Ulu A et al (2018) The causes of post-operative meningitis: the comparison of gram-negative and gram-positive pathogens. Turk Neurosurg 28(4):589–596PubMedGoogle Scholar
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    Magiorakos A-P, Srinivasan A, Carey RB et al (2012) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18(3):268–281.  https://doi.org/10.1111/j.1469-0691.2011.03570 CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Thomas Rogers
    • 1
  • Kevin Sok
    • 1
  • Timothy Erickson
    • 2
  • Elizabeth Aguilera
    • 3
  • Susan H. Wootton
    • 3
  • Kristy O. Murray
    • 2
  • Rodrigo Hasbun
    • 1
    Email author
  1. 1.Infectious Disease Division, Department of Internal MedicineMcGovern Medical School at the University of Texas Health Science Center in HoustonHoustonUSA
  2. 2.Department of PediatricsBaylor College of MedicineHoustonUSA
  3. 3.Infectious Disease Division, Department of PediatricsMcGovern Medical School at the University of Texas Health Science Center at HoustonHoustonUSA

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