The comparison of Gram-positive and Gram-negative healthcare-associated ventriculitis and meningitis in adults and children
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Healthcare-associated ventriculitis and meningitis (HCAVM) is associated with adverse clinical outcomes in the majority of patients [1, 2, 3]. A recent study demonstrated that Gram-negative HCAVM had a higher mortality rate than Gram-positive . The purpose of our study was to validate these findings and to compare clinical characteristics and outcomes between patients with Gram-positive and Gram-negative HCAVM.
We performed a retrospective analysis of patients diagnosed with HCAVM with a positive CSF Gram stain or culture at Texas Children’s Hospital (TCH) and Memorial Hermann Hospital (MHH) from December 2003 to January 2017. Baseline characteristics and laboratory chemistries were recorded at the time of CSF analysis. An adverse clinical outcome at discharge was defined as a Glasgow outcome scale 1–4 . Drug resistance profiles were defined using the method from Magiorakos et al. .
We wish to thank the Grant A. Starr foundation for their research support.
Compliance with ethical standards
Conflicts of interest
RH has received research support and is a speaker for Biofire®. All other authors have no conflicts of interest relevant to this research.
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