Intensive Care Medicine

, Volume 45, Issue 9, pp 1318–1320 | Cite as

Metabolomic profile of acute respiratory distress syndrome of different etiologies

  • José Luis Izquierdo-GarcíaEmail author
  • Nicolás Nin
  • Pablo Cardinal-Fernandez
  • Jesús Ruiz-Cabello
  • José Ángel Lorente

Dear Editor,

In a recent study, we reported the metabolic alterations related to acute respiratory distress syndrome (ARDS) in patients with influenza A pneumonia (IAP) [1]. We hypothesized that other types of acute lung injury causing ARDS may share the same metabolic alterations. As proof of concept, we have analyzed the metabolomic profiles of patients with and without ARDS induced by Streptococcus pneumoniae (SPP) (ARDS = 13; no ARDS = 17) or IAP (ARDS = 12; no ARDS = 18). Some of the results of these studies have been previously reported in the form of an abstract [2]. Patients with SPP were older (p < 0.05) and presented more often with renal failure (p < 0.05) (Table-S1). Serum samples were obtained within 24 h of presentation to the emergency department, before starting mechanical ventilation, and examined by nuclear magnetic resonance spectroscopy, as previously described [1, 3]. We quantified 16 characteristic serum metabolites, and statistical significance was determined...



This research was supported by the Spanish Ministry of Economy, Industry and Competitiveness (MEIC-AEI) Grant SAF2017-84494-C2-1-R, Comunidad de Madrid grant B2017/BMD3875, Instituto de Salud Carlos III FEDER Funds from EU (FIS PI 15/1942), Programa Red Guipuzcoana de Ciencia, Tecnología e Información 2018-CIEN-000058-01 and from the Gobierno Vasco, Dpto. Industria, Innovación, Comercio y Turismo under the ELKARTEK Program (Grant no. KK-2019/bmG19). JRC received funding from the BBVA Foundation (Ayudas a Equipos de investigación científica Biomedicina 2018). CIC biomaGUNE is supported by the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency, Grant no. MDM-2017-0720.

Compliance with ethical standards

Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Supplementary material

134_2019_5634_MOESM1_ESM.docx (24 kb)
Supplementary material 1 (DOCX 23 kb)


  1. 1.
    Izquierdo-Garcia JL, Nin N, Jimenez-Clemente J, Horcajada JP, Arenas-Miras MDM, Gea J, Esteban A, Ruiz-Cabello J, Lorente JA (2018) Metabolomic profile of ARDS by nuclear magnetic resonance spectroscopy in patients with H1N1 influenza virus pneumonia. Shock 50:504–510. CrossRefGoogle Scholar
  2. 2.
    Nin N, Izquierdo J, Cardinal P, Sanchez-Munoz I, Lopez-Cuenca S, Ruiz-Cabello J, Esteban A, Lorente J (2012) Metabolomic analysis as a diagnostic tool for acute respiratory distress syndrome caused by viral or bacterial pneumonia in humans. Intensive Care Med 38:S1–257. Google Scholar
  3. 3.
    Izquierdo-Garcia JL, Nin N, Ruiz-Cabello J, Rojas Y, de Paula M, Lopez-Cuenca S, Morales L, Martinez-Caro L, Fernandez-Segoviano P, Esteban A, Lorente JA (2011) A metabolomic approach for diagnosis of experimental sepsis. Intensive Care Med 37:2023–2032. CrossRefGoogle Scholar
  4. 4.
    Lindon JC, Holmes E, Nicholson JK (2001) Pattern recognition methods and applications in biomedical magnetic resonance. Prog Nucl Magn Reson Spectrosc 39:1–40. CrossRefGoogle Scholar
  5. 5.
    Serkova NJ, Standiford TJ, Stringer KA (2011) The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses. Am J Respir Crit Care Med 184:647–655. CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.CIBER de Enfermedades Respiratorias, CIBERESMadridSpain
  2. 2.Centro de Investigación Cooperativa en Biomateriales, CIC biomaGUNEDonostia-San SebastiánSpain
  3. 3.Departamento de Química-Física II, Facultad de FarmaciaUniversidad Complutense de MadridMadridSpain
  4. 4.Hospital EspañolMontevideoUruguay
  5. 5.Emergency Department, Fundacion de Investigacion HMHospital Universitario HM SanchinarroMadridSpain
  6. 6.Department of Critical CareHospital Universitario de GetafeMadridSpain
  7. 7.Universidad Europea de MadridMadridSpain

Personalised recommendations