Metabolomic profile of acute respiratory distress syndrome of different etiologies
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In a recent study, we reported the metabolic alterations related to acute respiratory distress syndrome (ARDS) in patients with influenza A pneumonia (IAP) . We hypothesized that other types of acute lung injury causing ARDS may share the same metabolic alterations. As proof of concept, we have analyzed the metabolomic profiles of patients with and without ARDS induced by Streptococcus pneumoniae (SPP) (ARDS = 13; no ARDS = 17) or IAP (ARDS = 12; no ARDS = 18). Some of the results of these studies have been previously reported in the form of an abstract . Patients with SPP were older (p < 0.05) and presented more often with renal failure (p < 0.05) (Table-S1). Serum samples were obtained within 24 h of presentation to the emergency department, before starting mechanical ventilation, and examined by nuclear magnetic resonance spectroscopy, as previously described [1, 3]. We quantified 16 characteristic serum metabolites, and statistical significance was determined...
This research was supported by the Spanish Ministry of Economy, Industry and Competitiveness (MEIC-AEI) Grant SAF2017-84494-C2-1-R, Comunidad de Madrid grant B2017/BMD3875, Instituto de Salud Carlos III FEDER Funds from EU (FIS PI 15/1942), Programa Red Guipuzcoana de Ciencia, Tecnología e Información 2018-CIEN-000058-01 and from the Gobierno Vasco, Dpto. Industria, Innovación, Comercio y Turismo under the ELKARTEK Program (Grant no. KK-2019/bmG19). JRC received funding from the BBVA Foundation (Ayudas a Equipos de investigación científica Biomedicina 2018). CIC biomaGUNE is supported by the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency, Grant no. MDM-2017-0720.
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Conflicts of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
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