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Prolonged corrected QT interval is associated with short-term and long-term mortality in critically ill patients: results from the FROG-ICU study

  • Tuija JavanainenEmail author
  • Shiro Ishihara
  • Etienne Gayat
  • Beny Charbit
  • Raija Jurkko
  • Raphaël Cinotti
  • Alexandre Mebazaa
  • on behalf of the FROG-ICU investigators
Letter

Notes

Funding

The original FROG ICU study was supported by grants from Assistance Publique–Hôpitaux de Paris (AOR01004) and from Société Française d’Anesthésie –Réanimation.

Compliance with ethical standards

Ethical approval

The study was approved by local ethics committees and conducted in accordance with the Declaration of Helsinki.

Conflicts of interest

Tuija Javanainen received personal unrestricted research grants from Paavo Nurmi Foundation, Paavo Ilmari Ahvenaisen säätiö and AstraZeneca Oy. Etienne Gayat received a research grant from Sphingotec, consultancy fees from Magnisense, Roche Diagnostics. Alexandre Mebazaa received speaker’s honoraria from Abbott, Novartis, Orion, Roche and Servier and a fee as a member of the advisory board and/or Steering Committee from Cardiorentis, Adrenomed, MyCartis, Neurotronik, and Sphingotec.

References

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    Pickham D, Helfenbein E, Shinn JA, Chan G, Funk M, Weinacker A, Liu JN, Drew BJ (2012) High prevalence of corrected QT interval prolongation in acutely ill patients is associated with mortality: results of the QT in Practice (QTIP) study. Crit Care Med 40:394–399CrossRefPubMedGoogle Scholar
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    Uvelin A, Pejaković J, Mijatović V (2017) Acquired prolongation of QT interval as a risk factor for torsade de pointes ventricular tachycardia: a narrative review for the anesthesiologist and intensivist. J Anesth 31:413–423CrossRefPubMedGoogle Scholar
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    Zhang Y, Post WS, Blasco-Colmenares E, Dalal D, Tomaselli GF, Guallara E (2011) Electrocardiographic QT interval and mortality: a meta-analysis. Epidemiology 22:660–670CrossRefPubMedGoogle Scholar
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    George T, Chase D, Peter J, Satyendra S, Kavitha R, George L, Thomas V (2015) Association between a prolonged corrected QT interval and outcomes in patients in a medical intensive care unit. Indian J Crit Care Med 19:326CrossRefPubMedGoogle Scholar
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    Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang C-E, Huikuri H et al (2013) HRS/EHRA/APHRS CONSENSUS STATEMENT Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. EP Europace 15:1389–1406CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Tuija Javanainen
    • 1
    • 2
    Email author
  • Shiro Ishihara
    • 1
    • 3
  • Etienne Gayat
    • 1
  • Beny Charbit
    • 4
  • Raija Jurkko
    • 2
  • Raphaël Cinotti
    • 1
    • 5
  • Alexandre Mebazaa
    • 1
  • on behalf of the FROG-ICU investigators
  1. 1.Department of Anesthesiology, Critical Care and Burn Unit, Hôpitaux Universitaires Saint Louis, Lariboisière, Assistance Publique, Hôpitaux de ParisUniversité Paris Diderot—Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERMParisFrance
  2. 2.Cardiology, Heart and Lung Center, Helsinki University HospitalUniversity of HelsinkiHelsinkiFinland
  3. 3.Department of CardiologyNippon Medical School Musashi-Kosugi HospitalKawasakiJapan
  4. 4.Department of Anesthesiology and Intensive CareCHU Reims, Hôpital Robert DebréReimsFrance
  5. 5.Anesthesia and Critical Care DepartmentHôtel DieuNantesFrance

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