Intensive Care Medicine

, Volume 44, Issue 6, pp 742–759 | Cite as

A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill

  • Jean-François TimsitEmail author
  • Mark Rupp
  • Emilio Bouza
  • Vineet Chopra
  • Tarja Kärpänen
  • Kevin Laupland
  • Thiago Lisboa
  • Leonard Mermel
  • Olivier Mimoz
  • Jean-Jacques Parienti
  • Garyphalia Poulakou
  • Bertrand Souweine
  • Walter Zingg


Intravascular catheters are inserted into almost all critically ill patients. This review provides up-to-date insight into available knowledge on epidemiology and diagnosis of complications of central vein and arterial catheters in ICU. It discusses the optimal therapy of catheter-related infections and thrombosis. Prevention of complications is a multidisciplinary task that combines both improvement of the process of care and introduction of new technologies. We emphasize the main component of the prevention strategies that should be used in critical care and propose areas of future investigation in this field.


Intravascular catheter Thrombosis Pulmonary emboli Sepsis Critically ill 


Compliance with ethical standards

Conflicts of interest

Dr. Chopra discloses receiving grant support from the Agency for Healthcare Quality and Research and honoraria for research talks as a visiting professor. Dr. Kärpänen has received honoraria to present at a symposium and attend an international conference supported by 3M. Since contributing to the manuscript, she has taken a Senior Clinical Research Specialist role at 3M Deutschland GmbH. Dr. Mermel has served as a consultant for Marvao Medical and Nobio. Dr. Mimoz received grant support from 3M and Carefusion-BD and honoraria for giving lectures from 3M and Carefusion-BD. Dr. Timsit received grant support from 3M and honoraria for giving lectures from 3M.

Supplementary material

134_2018_5212_MOESM1_ESM.docx (58 kb)
Supplementary material 1 (DOCX 58 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature and ESICM 2018

Authors and Affiliations

  • Jean-François Timsit
    • 1
    • 2
    Email author
  • Mark Rupp
    • 3
    • 4
  • Emilio Bouza
    • 5
    • 6
    • 7
  • Vineet Chopra
    • 8
  • Tarja Kärpänen
    • 9
  • Kevin Laupland
    • 10
  • Thiago Lisboa
    • 11
    • 12
  • Leonard Mermel
    • 13
    • 14
  • Olivier Mimoz
    • 15
    • 16
    • 17
  • Jean-Jacques Parienti
    • 18
    • 19
  • Garyphalia Poulakou
    • 20
  • Bertrand Souweine
    • 21
    • 22
  • Walter Zingg
    • 23
  1. 1.Université Paris Diderot/Hopital Bichat - Réanimation Medicale et des maladies infectieusesParisFrance
  2. 2.UMR 1137 - IAME Team 5 – DeSCID: Decision Sciences in Infectious DiseasesControl and care Inserm/Univ Paris DiderotParisFrance
  3. 3.Division of Infectious DiseasesUniversity of Nebraska Medical CenterOmahaUSA
  4. 4.Department of Infection Control and EpidemiologyNebraska MedicineOmahaUSA
  5. 5.Medicine Department, School of MedicineUniversidad Complutense de Madrid (UCM)MadridSpain
  6. 6.Department of Clinical Microbiology and Infectious DiseasesHospital General Universitario Gregorio MarañónMadridSpain
  7. 7.Instituto de Investigación Sanitaria Gregorio MarañónMadridSpain
  8. 8.Division of Hospital Medicine, Department of Medicine, Patient Safety Enhancement Program and Center for Clinical Management ResearchUniversity of MichiganAnn ArborUSA
  9. 9.Department of Clinical Microbiology, University Hospitals Birmingham NHS Foundation TrustQueen Elizabeth HospitalBirminghamUK
  10. 10.Department of MedicineRoyal Inland HospitalKamloopsCanada
  11. 11.Rede Institucional de Pesquisa e Inovação em Medicina Intensiva, Complexo Hospitalar Santa Casa de Misericordia de Porto AlegrePorto AlegreBrazil
  12. 12.Critical Care Department and Infection Control CommitteeHospital de Clinicas de Porto AlegrePorto AlegreBrazil
  13. 13.Department of Medicine, Alpert Medical School of Brown UniversityRhode Island HospitalProvidenceUSA
  14. 14.Division of Infectious Diseases and Department of Epidemiology and Infection ControlRhode Island HospitalProvidenceUSA
  15. 15.Service des Urgences-SAMU 86CHU de PoitiersPoitiersFrance
  16. 16.Université de Poitiers, UFR de Médecine PharmaciePoitiersFrance
  17. 17.INSERM U1070, Pharmacologie des Agents antiInfectieuxPoitiersFrance
  18. 18.Department of Biostatistics and Clinical ResearchCentre Hospitalier Universitaire (CHU)CaenFrance
  19. 19.INSERM Unité Mixte de Recherche Scientifique 1075 COMETE (N.T.) and EA4655 Risques MicrobiensCaenFrance
  20. 20.4th Department of Internal MedicineAttikon University General Hospital, Athens University School of MedicineAthensGreece
  21. 21.Service de Réanimation MédicaleHôpital Gabriel Montpied, CHU de Clermont-FerrandClermont-FerrandFrance
  22. 22.Université Clermont Auvergne, CNRS, LMGEClermont-FerrandFrance
  23. 23.Infection Control Program and WHO Collaborating Centre for Patient SafetyUniversity of Geneva HospitalsGenevaSwitzerland

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