Intensive Care Medicine

, Volume 45, Issue 1, pp 75–77 | Cite as

What’s new in severe pulmonary embolism?

  • Nadia AissaouiEmail author
  • Stavros Konstantinides
  • Guy Meyer
What's New in Intensive Care


Severe pulmonary embolism (PE) remains a major cause of mortality. For intensivists managing the most “severe” forms of PE, we highlight the main recent advances in the care of such patients including risk stratification, diagnostic algorithms, general supportive care, and reperfusion therapy.

Quickly identify patients presenting with severe PE but also patients with intermediate-high-risk PE

Severe or high-risk PE is defined by cardiac arrest, or persistent hypotension (i.e., systolic blood pressure < 90 mmHg or a systolic pressure drop by 40 mmHg, for > 15 min, if not caused by new onset arrhythmia, hypovolemia, or sepsis) accompanied by signs of end-organ hypoperfusion [1, 2, 3]. High-risk PE represents less than 5% of all acute PE and constitutes a medical emergency, associated with a 15–50% risk of in-hospital death, particularly during the first hours after admission [1, 2, 3]. Among initially hemodynamically stable patients, about 10% may suffer early clinical and...

Supplementary material

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Supplementary material 1 (DOCX 26 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature and ESICM 2018

Authors and Affiliations

  • Nadia Aissaoui
    • 1
    • 2
    Email author
  • Stavros Konstantinides
    • 3
    • 4
  • Guy Meyer
    • 5
    • 6
  1. 1.Department of Critical Care UnitAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP)ParisFrance
  2. 2.Université Paris-Descartes, INSERM U970ParisFrance
  3. 3.Center for Thrombosis and Hemostasis (CTH)Johannes Gutenberg University MainzMainzGermany
  4. 4.Department of CardiologyDemocritus University of ThraceAlexandroupolisGreece
  5. 5.Department of PulmonologyAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP)ParisFrance
  6. 6.Université Paris Descartes, INSERM CIC1418ParisFrance

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