Paediatric acute kidney injury: can we match therapy with resources around the world?

What's New in Intensive Care


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Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


  1. 1.
    Mehta RL, Burdmann EA, Cerda J, Feehally J, Finkelstein F et al (2016) Recognition and management of acute kidney injury in the International Society of Nephrology 0 by 25 Global Snapshot: a multinational cross-sectional study. Lancet 387:2017–2025CrossRefPubMedGoogle Scholar
  2. 2.
    Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL, for the AWARE Investigators (2017) Epidemiology of acute kidney injury in critically ill children and young adults. N Engl J Med 376:11–20CrossRefPubMedGoogle Scholar
  3. 3.
    Jetton JG, Bookhaker LJ, Sethi SK, Wazir S, Rohatgi S, on behalf of the Neonatal Kidney Collaborative (NKC) et al (2017) Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicenter, multinational, observational cohort study. Lancet Child Adolesc Health 1:184–194CrossRefGoogle Scholar
  4. 4.
    Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R et al (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock. Crit Care Med 45:486–552CrossRefPubMedGoogle Scholar
  5. 5.
    Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, FEAST Trial Group et al (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364:2483–2495CrossRefPubMedGoogle Scholar
  6. 6.
    Hilton AK, Bellomo R (2012) A critique of fluid bolus resuscitation in severe sepsis. Crit Care 16:302–306CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Shum HP, Yan WW, Chan TM (2016) Recent knowledge on the pathophysiology of septic acute kidney injury: a narrative review. J Crit Care 31:82–89CrossRefPubMedGoogle Scholar
  8. 8.
    Basu RK, Zappitelli M, Brunner L, Wang Y, Wong HR, Chawla LS, Wheeler DS, Goldstein SL (2014) Derivation and validation of the renal angina index to improve the prediction of acute kidney injury in critically ill children. Kidney Int 85:659–667CrossRefPubMedGoogle Scholar
  9. 9.
    Menon S, Goldstein SL, Mottes T, Fei L, Kaddourah A et al (2016) Urinary biomarker incorporation into the renal angina index early in intensive care unit admission optimizes acute kidney injury prediction in critically ill children: a prospective cohort study. Nephrol Dial Transplant 31:586–594CrossRefPubMedGoogle Scholar
  10. 10.
    Goldstein SL, Mottes T, Simpson K, Barclay C, Muething S et al (2016) A sustained quality improvement program reduces nephrotoxic medication-associated acute kidney injury. Kidney Int 90:212–221CrossRefPubMedGoogle Scholar
  11. 11.
    Ronco C, Ricci Z, Goldstein S (2015) (R)evolution in the management of acute kidney injury in newborns. Am J Kidney Dis 66:206–211CrossRefPubMedGoogle Scholar
  12. 12.
    Cullis B, Abdelraheem M, Abrahams G, Balbi A, Cruz DN et al (2014) Peritoneal dialysis for acute kidney injury. Perit Dial Int 34:494–517CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Benoit SM, Devarajan P (2017) Acute kidney injury: emerging pharmacotherapies in current clinical trials. Pediatr Nephrol. Google Scholar
  14. 14.
    Mehta RL, Cerdá J, Burdmann EA, Tonelli M, García-García G et al (2015) International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet 385(9987):2616–2643CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature and ESICM 2018

Authors and Affiliations

  • Akash Deep
    • 1
  • Jordan M. Symons
    • 2
  • Mignon McCulloch
    • 3
  1. 1.Chair of Renal/CRRT section of ESPNICConsultant Intensivist, King’s College HospitalLondonUK
  2. 2.Seattle Children’s HospitalUniversity of Washington School of MedicineSeattleUSA
  3. 3.Red Cross War Memorial Children’s HospitalUniversity of Cape TownCape TownSouth Africa

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