Chlorhexidine use in adult patients on ICU
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Chlorhexidine (CHG) is a biguanide cationic antiseptic molecule, which has been incorporated into mouthwash solutions, dental gels, dressings, washcloths and central venous catheters (CVC). It has become the first-choice antiseptic to reduce healthcare-associated infections. However, the widespread use of CHG has raised concerns about increasing rates of resistance and cross-resistance to antibiotics. In this short review the antimicrobial characteristics of CHG including microbial resistance and its main clinical applications in ICU are presented.
CHG is available in a range of concentrations from 0.05% to 4% (w/v) in aqueous solutions and in combination with different alcohols. Formulations that contain both CHG and alcohol, such as 70% (v/v) isopropyl alcohol, advantageously exhibit the relatively rapid antimicrobial activity of the alcohol with the persisting activity of residual CHG.
CHG has broad-spectrum non-sporicidal antimicrobial activity against...
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