Understanding cardiovascular physiology of ageing

Understanding the Disease



Ms. Janet Fong is the artist who drew Fig. 1.

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Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


  1. 1.
    Loffredo FS, Nikolova AP, Pancoast JR et al (2014) Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium. Circ Res 115(1):97–107.  https://doi.org/10.1161/CIRCRESAHA.115.302929 CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Olivetti G, Melissari M, Capasso JM, Anversa P (1991) Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res 68:1560–1568CrossRefPubMedGoogle Scholar
  3. 3.
    Echocardiographic Normal Ranges Meta-Analysis of the Left Heart Collaboration (2015) Ethnic-specific normative reference values for echocardiographic LA and LV size, LV mass, and systolic function: the EchoNoRMAL Study. JACC Cardiovasc Imaging 8:656–665.  https://doi.org/10.1016/j.jcmg.2015.02.014 CrossRefGoogle Scholar
  4. 4.
    Upadhya B, Pisani B, Kitzman DW (2017) Evolution of a geriatric syndrome: pathophysiology and treatment of heart failure with preserved ejection fraction. JAGS 65:2431–2440.  https://doi.org/10.1111/jgs.15141 CrossRefGoogle Scholar
  5. 5.
    Wolsk E, Bakkestrøm R, Thomsen H et al (2017) The influence of age on hemodynamic parameters during rest and exercise in healthy individuals. JACC Heart Fail 5:337–346.  https://doi.org/10.1016/j.jchf.2016.10.012 CrossRefPubMedGoogle Scholar
  6. 6.
    Fleg JL, Lakatta EG (1988) Role of muscle loss in the age-associated reduction in VO2 max. J Appl Physiol 65:1147–1151.  https://doi.org/10.1152/jappl.1988.65.3.1147 CrossRefPubMedGoogle Scholar
  7. 7.
    Larson ED et al (2013) Depressed pacemaker activity of sinoatrial node myocytes contribute to the age-dependent decline in maximum heart rate. PNAS 110:18011–18016.  https://doi.org/10.1073/pnas.1308477110 CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Lakatta EG (1993) Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans. Circulation 87:631–636CrossRefPubMedGoogle Scholar
  9. 9.
    Fleg JL, Lakatta EG (2005) Normal aging of the cardiovascular system. In: Aronow A (ed) Cardiovascular disease in the elderly. Marcel Dekker Inc, New York, pp 1–52Google Scholar
  10. 10.
    Strait JB, Lakatta EG (2012) Ageing-associated cardiovascular changes and their relationship to heart failure. Heart Fail Clin 8:143–164.  https://doi.org/10.1016/j.hfc.2011.08.011 CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Harvey A, Montezano AC, Touyz RM (2015) Vascular biology of ageing—implications in hypertension. J Mol Cell Cardiol 83:112–121.  https://doi.org/10.1016/j.yjmcc.2015.04.011 CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Nilsson PM, Khalili P, Franklin SS (2014) Blood pressure and pulse wave velocity as metrics for evaluating pathologic ageing of the cardiovascular system. Blood Press 23:17–30.  https://doi.org/10.3109/08037051.2013.796142 CrossRefPubMedGoogle Scholar
  13. 13.
    Geokas MC, Lakatta EG, Makinodan T, Timiras PS (1990) The aging process. Ann Int Med 1990(113):455–466CrossRefGoogle Scholar
  14. 14.
    Kelly R, Hayward C, Avolio A, O’Rourke M (1989) Noninvasive determination of age-related changes in the human arterial pulse. Circulation 80:1652–1659CrossRefPubMedGoogle Scholar
  15. 15.
    O’Rourke MF, Pauca A, Jiang XJ (2001) Pulse wave analysis. Br J Clin Pharmacol 51:507–522CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature and ESICM 2018

Authors and Affiliations

  1. 1.Department of Anaesthesia and Intensive CareHaukeland University HospitalBergenNorway
  2. 2.Department of Clinical MedicineUniversity of BergenBergenNorway
  3. 3.Department of Heart DiseaseHaukeland University HospitalBergenNorway
  4. 4.Department of Clinical ScienceUniversity of BergenBergenNorway
  5. 5.Department of Anaesthesia and Intensive CarePrince of Wales Hospital, Chinese UniversityHong KongPeople’s Republic of China

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