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Intensive Care Medicine

, Volume 44, Issue 5, pp 669–671 | Cite as

Albumin infusion improves endothelial function in septic shock patients: a pilot study

  • Geoffroy Hariri
  • Jérémie Joffre
  • Stephanie Deryckere
  • Naïke Bigé
  • Guillaume Dumas
  • Jean-Luc Baudel
  • Eric Maury
  • Bertrand Guidet
  • Hafid Ait-OufellaEmail author
Letter

Dear Editor,

Sepsis is a life-threatening condition in response to microbe injury, leading to tissue hypoperfusion, multiorgan failure and death. Human and experimental studies have shown that endothelial dysfunction is involved in microcirculatory blood flow impairment through several mechanisms including vasomotor tone dysregulation, activation of coagulation and glycocalyx damage [1]. Experimental studies suggested that human serum albumin (HSA) could have protective effects on endothelial cells [2], but such a hypothesis has never been directly tested in vivo. The aim of this study was to compare the effect of saline versus HSA bolus infusion on endothelial function in septic shock patients.

Methods

In our intensive care unit, we prospectively included adult patients admitted for septic shock [3]. Standard patient management was guided by international guidelines [4], including fluid resuscitation (30 mL/kg of crystalloids) and norepinephrine infusion, to achieve a mean arterial...

Notes

Author contributions

Study concept and design, all authors. Acquisitions of data, GH, JJ, SD, NB, JLB, and HAO. Drafting of the manuscript, GH, JJ, GD, HAO, EM and BG. Critical revision of manuscript, all authors. Statistical analysis, GH and HAO.

Funding

We received a Grant from LFB to conduct this study. The funding source had no role in the design and conduct of the study. In addition, the funding source had no role in management, analysis of the data, manuscript preparation or decision to submit the manuscript for publication.

Compliance with ethical standards

Conflicts of interest

B. Guidet has received honorium from LFB biomedicaments and Grifols.

Supplementary material

134_2018_5075_MOESM1_ESM.docx (158 kb)
Supplementary material 1 (DOCX 157 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature and ESICM 2018

Authors and Affiliations

  • Geoffroy Hariri
    • 1
  • Jérémie Joffre
    • 1
    • 2
  • Stephanie Deryckere
    • 1
  • Naïke Bigé
    • 1
  • Guillaume Dumas
    • 1
  • Jean-Luc Baudel
    • 1
  • Eric Maury
    • 1
    • 2
    • 3
  • Bertrand Guidet
    • 1
    • 2
    • 3
  • Hafid Ait-Oufella
    • 1
    • 2
    • 4
    Email author
  1. 1.Assistance Publique-Hôpitaux de Paris (AP-HP), Service de Réanimation MédicaleHôpital Saint-AntoineParis Cedex 12France
  2. 2.Université Pierre-et-Marie Curie-Paris 6ParisFrance
  3. 3.Inserm U1136ParisFrance
  4. 4.Inserm U970Centre de Recherche Cardiovasculaire de Paris (PARCC)ParisFrance

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