Albumin infusion improves endothelial function in septic shock patients: a pilot study
Sepsis is a life-threatening condition in response to microbe injury, leading to tissue hypoperfusion, multiorgan failure and death. Human and experimental studies have shown that endothelial dysfunction is involved in microcirculatory blood flow impairment through several mechanisms including vasomotor tone dysregulation, activation of coagulation and glycocalyx damage . Experimental studies suggested that human serum albumin (HSA) could have protective effects on endothelial cells , but such a hypothesis has never been directly tested in vivo. The aim of this study was to compare the effect of saline versus HSA bolus infusion on endothelial function in septic shock patients.
Study concept and design, all authors. Acquisitions of data, GH, JJ, SD, NB, JLB, and HAO. Drafting of the manuscript, GH, JJ, GD, HAO, EM and BG. Critical revision of manuscript, all authors. Statistical analysis, GH and HAO.
We received a Grant from LFB to conduct this study. The funding source had no role in the design and conduct of the study. In addition, the funding source had no role in management, analysis of the data, manuscript preparation or decision to submit the manuscript for publication.
Compliance with ethical standards
Conflicts of interest
B. Guidet has received honorium from LFB biomedicaments and Grifols.
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