Intensive Care Medicine

, Volume 44, Issue 2, pp 241–243 | Cite as

Prone position in ARDS: a simple maneuver still underused

  • Davide ChiumelloEmail author
  • Silvia Coppola
  • Sara Froio

A recent international multicenter prospective study enrolling 29,144 patients who received invasive or non-invasive ventilation reported that acute respiratory distress syndrome (ARDS) was present in 23% of the mechanically ventilated patients [1]. In recent years, the ARDS mortality rate ranged between 28% and 35% [1, 2] with lower survival in patients with more severe ARDS [1]. The main supportive therapy in ARDS is invasive mechanical ventilation combining lung protective ventilation to prevent ventilator-associated lung injury with a restrictive fluid therapy to limit/prevent lung edema [3, 4]. However, the optimal approach for lung protective ventilation is still questionable [5]. The recent American/European guideline and an expert opinion on respiratory support in ARDS patients recommended a low tidal volume ventilation (i.e., 6 ml/kg of ideal body weight, or lower in case of plateau pressure higher than 30 cm H2O) with positive end-expiratory pressure (PEEP) adjusted according to the respiratory mechanics (lung and chest wall elastance), driving pressure, gas exchange, and lung imaging [6, 7]. In addition, in case of severe ARDS the use of prone position, according to previous positive studies [8, 9, 10], has been recommended. However, the use of prone position in daily clinical practice in ARDS ranges between 7% and 8% of the mechanically ventilated patients [1, 2]. In the current issue of Intensive Care Medicine, Guerin et al. reports the results of a prospective observational international study (APRONET study) evaluating the prevalence of the application of prone position in ARDS patients, the reasons for not applying it, and the related complications [11]. This 1-day prevalence study was repeated four times between April 2016 and January 2017. Intubated/tracheostomized ARDS patients, according to the Berlin definition, were screened. Up to 141 intensive care units (ICUs) from 20 countries participated, with 735 enrolled ARDS patients, reporting an ARDS prevalence between 8.9% and 13.3%. At least one proning session was completed in 13.7% of the patients; the rate of proning significantly differed among mild, moderate, and severe ARDS patients (5.9%, 10.3%, and 32.9%, respectively). The main reasons for not proning were the absence of severe hypoxemia according to clinical judgment (64%), a mean arterial pressure lower than 65 mmHg (5.7%), and end of life decision (4.2%). Complications of the prone position session were observed in 11.9% of proned patients, mainly related to hypoxemia and the endotracheal tube.

Despite the possible selection bias of ICUs, as most of them were located in European countries (Spain, French, Italy) where the use of prone position is higher compared to non-European countries, a clinically, although not statistically, relevant increase in the rate of proning ARDS patients was found compared to previous studies [2, 9]. More importantly, the highest increase was found in patients with severe ARDS (PaO2/FiO2 lower than 100) which accounts for the worse outcome, but in whom the prone position significantly improves the survival. The reason for this increase in the use of prone position was mainly due to the positive randomized controlled studies recently published [8, 9, 10]. However, compared to the possible “theoretical” application in all the moderate/severe and severe ARDS patients [6, 7], currently the prone position is applied in only between 16% and 33% of the patients presenting the criteria. On the contrary, despite the quality of the current evidence being low and the lack of a definitive conclusion on the outcome [12], the recruitment maneuvers are applied in 32% of severe ARDS patients [1]. A similar rate of application was found for neuromuscular block in severe ARDS [1]. What could be the possible reasons for not broadly proning ARDS patients in ICUs, while outside intensive care, such as in the operating room, the prone position is routinely used when indicated? Possible explanations could be the feelings of the physicians that prone position could induce negative side effects such as the risk of artificial airway displacement, the high number of physicians and nurses required for the maneuver, with a consequent increase in workload, the difficulty to manage secretions, enteral nutrition, and the low number of ARDS cases in small volume intensive care.

However, in the present study the authors found that evaluation of the level of hypoxemia as not severe enough and hemodynamic instability were the main reasons for not proning patients. Although the simple cutoff value of a low oxygenation (PaO2/FiO2 lower than 100 or 150) with a minimum PEEP level of 10 cmH2O could be reasonable to apply or not apply the prone position in the early phase, hemodynamic impairment is not a contraindication. On the contrary, by recruiting the dorsal regions (dependent lung), improving the gas exchange, even if with an unpredictable magnitude [13, 14], and increasing the intra-abdominal pressure, the prone position might reduce the right ventricular afterload, reduce the pulmonary arterial pressure, and increase the cardiac output [15]. Interestingly, in the PROSEVA trial a significantly lower amount of cardiac arrest occurred in the prone compared to the supine group [9]. Last but not least is the issue of safety of the prone position in ARDS patients. The previous studies reported a rate of severe complications directly attributable to the turning procedures, such as extubation, kinking of the endotracheal tube, or dislodging of the Swan-Ganz catheter, of between 8% and 12%. Compared to the previous data, the present study showed a rate of severe complications of the prone position session of lower than 5%.

Although the rate of application of the prone position has been increasing throughout the years with a low rate of complications, in clinical practice it is still considered as a rescue maneuver. On the contrary, it should be considered in all moderate/severe ARDS patients—irrespective of the level of hypoxemia—to attenuate ventilator-induced lung injury and improve hemodynamics.


  1. 1.
    Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson T, Wrigge H, Slutsky AS, Pesenti A, for the LUNG SAFE and the ESICM Trial Group (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315(8):788–800CrossRefPubMedGoogle Scholar
  2. 2.
    Esteban A, Frutos-Vivar F, Muriel A, Ferguson DN, Penuelas O, Abraira V, Raymondos K, Rios F, Nin N, Apezteguia C, Violi DA, Thille AW, Brochard L, Gonzalez M, Villagomez AJ, Hurtado J, Davies RA, Du B, Maggiore SM, Pelosi P, Soto L, Tomicic V, D’Empaire G, Matamis D, Rbroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibabja M, Amin P, Ypunsuck K, Kuiper MA, Bulow H-H, Ali Zeggwagh A, Anzueto A (2013) Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med 188(2):220–230CrossRefPubMedGoogle Scholar
  3. 3.
    Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, Takagaki TY, Carvalho CR (1998) Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 338(6):347–354CrossRefPubMedGoogle Scholar
  4. 4.
    Kollef MH, Schuster DP (1995) The acute respiratory distress syndrome. N Engl J Med 332:27–37CrossRefPubMedGoogle Scholar
  5. 5.
    Ferguson ND, Fan E, Camporota L, Antolenni M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, Rhodes A, Slutsky AS, Vicent JL, Rubenfeld GD, Thompson BT, Ranieri VM (2012) The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med 38(10):1573–1582CrossRefPubMedGoogle Scholar
  6. 6.
    Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, Adhikari NKJ, Amato MBP, Branson R, Brower RG, Ferguson ND, Gajic O, Gattinoni L, Hess D, Mancebo J, Meade MO, McAuley DF, Pesenti A, Ranieri VM, Rubenfeld GD, Rubin E, Seckel M, Slutsky AS, Talmor D, Thompson BT, Wunsch H, Uleryk E, Brozek J, Brochard LJ, American Thoracic Society, European Society of Intensive Care Medicine, Society of Critical Care Medicine (2017) Clinical practice guideline: mechanical ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 195(9):1253–1263CrossRefPubMedGoogle Scholar
  7. 7.
    Chiumello D, Brochard L, Marini JJ, Slustky AS, Mancebo J, Ranieri VM, Thompson BT, Papazian L, Schultz MJ, Amato M, Gattinoni L, Mercat A, Pesenti A, Talmor D, Vincent J-L (2012) Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Crit Care 21:240CrossRefGoogle Scholar
  8. 8.
    Taccone P, Pesenti A, Latini R, Polli F, Vagginelli F, Mietto C, Caspani L, Raimondi F, Bordone G, Iapichino G, Mancebo J, Guerin C, Ayzac L, Blanch L, Fumagalli R, Tognoni G, Gattinoni L, for the Prone-Supine II Study Group (2009) Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA 302(18):1977–1984CrossRefPubMedGoogle Scholar
  9. 9.
    Guerin C, Reignier J, Richard J-C, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Baboi L, Ayzac L, for the PROSEVA Study Group (2013) Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368:23CrossRefGoogle Scholar
  10. 10.
    Mancebo J, Fernandez R, Blanch L, Rialp G, Gordo F, Ferrer M, Rodriguez F, Garro P, Ricart P, Vallverdu I, Gich I, Castano J, Saura P, Dominguez G, Bonet A, Albert RK (2006) A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med 173:1233–1239CrossRefPubMedGoogle Scholar
  11. 11.
    Guerin C, Beuret P, Bellani G, Garcia-Olivares P, Roca O, Meertens JH, Azevedo Maia P, Becher T, Peterson J, Larson A, Gurjar M, Hajjej Z, Kovari F, Assiri AH, Mainas E, Hasan MS, Morocho-Tutillo DR, Baboi L, Chretien JM, Francois G, Chen L, Brochard L, Mercat A (2017) A prospective international observational prevalence study on prone positioning ARDS patients: the APRONET (ARDS Prone Position Network) study. Intensive Care Med.
  12. 12.
    Suzumura EA, Amato MBP, Cavalcanti AB (2015) Understanding recruitment maneuvers. Intensive Care Med. PubMedCrossRefGoogle Scholar
  13. 13.
    Haddam M, Zieleskiewicz L, Perbet S, Baldovini A, Guervilly C, Arbelot C, Noel A, Vigne C, Hammad E, Antonini F, Lehingue S, Peytel E, Lu Q, Bouhemad B, Golmard JL, Langeron O, Martin C, Muller L, Rouby JJ, Constantin JM, Papazian L, Leone M (2016) Lung ultrasonography for assessment of oxygenation response to prone position ventilation in ARDS. Intensive Care Med. PubMedCrossRefGoogle Scholar
  14. 14.
    Guerin C, Gattinoni L (2016) Assessment of oxygenation response to prone position ventilation in ARDS by lung ultrasonography. Intensive Care Med 42(10):1601–1603CrossRefPubMedGoogle Scholar
  15. 15.
    Jozwiak M, Teboul J-L, Anguel N, Persichini R, Silva S, Chemla D, Richard C, Monnet X (2013) Beneficial hemodynamic effects of prone positioning in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 188(12):1428–1433CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature and ESICM 2018

Authors and Affiliations

  1. 1.Dipartimento di Scienze della SaluteUniversità degli Studi di MilanoMilanItaly
  2. 2.SC Anestesia e RianimazioneASST Santi Paolo e CarloMilanItaly

Personalised recommendations