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Intensive Care Medicine

, Volume 44, Issue 8, pp 1310–1314 | Cite as

Understanding the role of host immune responses in invasive candidiasis

  • Jigar V. Desai
  • Frank L. van de Veerdonk
  • Michail S. Lionakis
Understanding the Disease

Invasive candidiasis is the most common nosocomial bloodstream mycosis in the ICU affecting > 250,000 individuals annually worldwide [1]. It is most often caused by Candida albicans, a commensal yeast of mucosal surfaces, although infections by non-albicans species, including C. glabrata, C. tropicalis and C. parapsilosis are increasing [1]. The recent global emergence of C. auris raises public health concerns because of the species’ multidrug-resistance and resilience to antiseptics, its misidentification by routine microbiological techniques, and its persistence on human skin and hospital environment that causes hospital-associated horizontal transmission and outbreaks [2].

Invasive candidiasis: when a commensal becomes an opportunistic pathogen

Candida asymptomatically colonizes the gastrointestinal mucosa in ~ 50–70% of healthy individuals. The recently-characterized inherited mutations that impair IL-17 immunity (IL17F/IL17RA/IL17RC/ACT1/RORC/STAT3/gain-of-function STAT1) have...

Notes

Acknowledgements

This work was supported by funding from the Division of Intramural Research (DIR), NIAID/NIH.

Compliance with ethical standard

Conflicts of interest

The authors declare no conflicts of interest pertaining to the contents of the current manuscript.

Supplementary material

134_2017_4988_MOESM1_ESM.docx (13 kb)
Supplementary material 1 (DOCX 12 kb)

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Copyright information

© US Government (outside the USA) 2017

Authors and Affiliations

  • Jigar V. Desai
    • 1
  • Frank L. van de Veerdonk
    • 2
  • Michail S. Lionakis
    • 1
  1. 1.Fungal Pathogenesis Section, Laboratory of Clinical Immunology and MicrobiologyNational Institute of Allergy & Infectious Diseases, National Institutes of HealthBethesdaUSA
  2. 2.Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI)Radboud University Medical CenterNijmegenThe Netherlands

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