Intensive Care Medicine

, Volume 43, Issue 9, pp 1352–1365 | Cite as

The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation

  • Samir Jaber
  • Giacomo Bellani
  • Lluis Blanch
  • Alexandre Demoule
  • Andrés Esteban
  • Luciano Gattinoni
  • Claude Guérin
  • Nicholas Hill
  • John G. Laffey
  • Salvatore Maurizio Maggiore
  • Jordi Mancebo
  • Paul H. Mayo
  • Jarrod M. Mosier
  • Paolo Navalesi
  • Michael Quintel
  • Jean Louis Vincent
  • John J. Marini
Research Agenda


In an important sense, support of the respiratory system has been a defining characteristic of intensive care since its inception. The pace of basic and clinical research in this field has escalated over the past two decades, resulting in palpable improvement at the bedside as measured by both efficacy and outcome. As in all medical research, however, novel ideas built upon observations are continually proposed, tested, and either retained or discarded on the basis of the persuasiveness of the evidence. What follows are concise descriptions of the current standards of management practice in respiratory support, the areas of present-day uncertainty, and our suggested agenda for the near future of research aimed at testing current assumptions, probing uncertainties, and solidifying the foundation on which to base our progress to the next level.


Acute respiratory failure Mechanical ventilation Non-invasive ventilation Airways Intubation Weaning 


Compliance with ethical standards

Conflicts of interest

Dr Blanch is inventor of a US patent owned by Corporació Sanitaria Parc Taulí: “Method and system for managing related patient parameters provided by a monitoring device,” US Patent No. 12/538,940. He owns stock options in BetterCare S.L., a research and development start-up of Corporació Sanitària Parc Taulí (Spain). Dr Demoule reports personal fees from Maquet, grants, personal fees, and non-financial support from Covidien, personal fees from MSD, grants and non-financial support from Philips, non-financial support from Drager, grants from Resmed, and personal fees from Fisher and Paykel, all outside the submitted work. Dr Jaber reports receiving consulting fees from Drager, Hamilton, Maquet, and Fisher and Paykel. Dr Maggiore is the principal investigator of the RINO trial (nasal high-flow vs Venturi mask after extubation), sponsored by Fisher and Paykel Healthcare, and has received research grants from Fisher and Paykel Healthcare and lecture fees from Draeger Medical and GE Healthcare. Dr Mancebo reports the following: Covidien and Maquet—research support; Faron—steering committee member; Covidien and Hamilton—honoraria for speaking at a meeting. Dr. Navalesi’s research laboratory has received equipment and grants from Maquet Critical Care, Draeger, and Intersurgical S.p.A. He has also received honoraria/speaking fees from Maquet Critical Care, Draeger, Breas, Philips, Resmed, and Hillrom. Dr Navalesi contributed to the development of the helmet Next, whose license for patent belongs to Intersurgical S.p.A., and receives royalties for that invention. Dr Quintel acts as advisor for Xenios and Baxter. CG, JGL, JJM, JMM, PM, and JLV declare no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany and ESICM 2017

Authors and Affiliations

  • Samir Jaber
    • 1
  • Giacomo Bellani
    • 2
    • 3
  • Lluis Blanch
    • 4
    • 5
  • Alexandre Demoule
    • 6
    • 7
  • Andrés Esteban
    • 8
  • Luciano Gattinoni
    • 9
  • Claude Guérin
    • 10
    • 11
  • Nicholas Hill
    • 12
  • John G. Laffey
    • 13
    • 14
  • Salvatore Maurizio Maggiore
    • 15
  • Jordi Mancebo
    • 16
    • 17
  • Paul H. Mayo
    • 19
  • Jarrod M. Mosier
    • 20
  • Paolo Navalesi
    • 21
  • Michael Quintel
    • 8
  • Jean Louis Vincent
    • 22
  • John J. Marini
    • 18
  1. 1.Department of Anesthesiology and Critical Care Medicine B (DAR B), Saint-Eloi HospitalUniversity Teaching Hospital of Montpellier, INSERM U104680MontpellierFrance
  2. 2.Department of Medicine and SurgeryUniversity of Milan-BicoccaMonzaItaly
  3. 3.Department of Emergency and Intensive CareSan Gerardo HospitalMonzaItaly
  4. 4.Critical Care Center, Parc Tauli University Hospital, Institut de Investigació i Innovació Parc Taulí, I3PTUniversitat Autònoma de BarcelonaSabadellSpain
  5. 5.CIBER Enfermedades Respiratorias, ISCIIIMadridSpain
  6. 6.UMRS1158 Neurophysiologie Respiratoire Expérimentale et CliniqueSorbonne Universités, UPMC Univ Paris 06, INSERMParisFrance
  7. 7.Service de Pneumologie et Réanimation Médicale (Département “R3S”)AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles FoixParisFrance
  8. 8.Hospital Universitario de Getafe, CIBER de Enfermedades RespiratoriasMadridSpain
  9. 9.Department of Anesthesiology, Emergency and Intensive Care MedicineUniversity of GöttingenGöttingenGermany
  10. 10.Service de réanimation médicaleHopital de la croix rousseLyonFrance
  11. 11.Université de Lyon and INSERM 955CréteilFrance
  12. 12.Pulmonary Division APC 479ARhode Island HospitalProvidenceUSA
  13. 13.Departments of Anesthesia and Critical Care Medicine, St Michael’s HospitalCritical Illness and Injury Research Centre, Keenan Research Centre for Biomedical ScienceTorontoCanada
  14. 14.Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care MedicineUniversity of TorontoTorontoCanada
  15. 15.Department of Medical, Oral and Biotechnological Sciences, School of Medicine and Health Sciences, Section of AnesthesiaAnalgesia, Perioperative and Intensive Care, “SS. Annunziata” Hospital, “Gabriele d’Annunzio” University of Chieti-PescaraChietiItaly
  16. 16.Department of MedicineUniversity of Montréal, Division of Intensive Care at Centre Hospitalier Université de Montréal (CHUM), Centre Recherche CHUMMontréalCanada
  17. 17.Institut de Recerca Hospital de St PauBarcelonaSpain
  18. 18.Punmonary and Critical Care Medicine, Regions HospitalUniversity of MinnesotaMinneapolis/Saint PaulUSA
  19. 19.Division of PulmonaryCritical Care and Sleep Medicine, Northwell Health NSUH/LIJNew Hyde ParkUSA
  20. 20.Department of Emergency Medicine, Department of Medicine, Division of Pulmonary, Allergy, Critical Care, and SleepUniversity of ArizonaTucsonUSA
  21. 21.Department of Medical and Surgical Sciences, Anesthesia and Intensive CareMagna Graecia UniversityCatanzaroItaly
  22. 22.Department of Intensive Care, Erasme University HospitalUniversité Libre de BruxellesBrusselsBelgium

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