Intensive care medicine research agenda on cardiac arrest
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Over the last 15 years, treatment of comatose post-cardiac arrest patients has evolved to include therapeutic strategies such as urgent coronary angiography with percutaneous coronary intervention (PCI), targeted temperature management (TTM)—requiring mechanical ventilation and sedation—and more sophisticated and cautious prognostication. In 2015, collaboration between the European Resuscitation Council (ERC) and the European Society for Intensive Care Medicine (ESICM) resulted in the first European guidelines on post-resuscitation care. This review addresses the major recent advances in the treatment of cardiac arrest, recent trials that have challenged current practice and the remaining areas of uncertainty.
KeywordsCardiopulmonary resuscitation Cardiac arrest Basic life support Advanced life support Post-resuscitation care Prognostication
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Conflicts of interest
JPN: Editor-in-Chief, Resuscitation; funding from the National Institute for Health Research to evaluate interventions in cardiac arrest including airway management (AIRWAYS-2 study) and adrenaline (PARAMEDIC-2 study). RAB: None declared SB: National Health and Medical Research Grants to undertake clinical trials in controlled oxygenation and mild hypercarbia after cardiac arrest. BJB: None declared. CC: None declared. TC: Co-investigator TTM trial; senior investigator TTM-2 trial. RWK: Research grants for studies on AED use from Physio-Control, Philips Medical, Zoll Medical, Cardiac Science, Defibtech. Advisor (unpaid) for Physio-Control and HeartSine. PJK: PI for the NIH-supported Resuscitation Outcomes Consortium, University of Washington. GN: None declared. GDP: Funding from the National Institute for Health Research to evaluate interventions in cardiac arrest including mechanical CPR and adrenaline (PARAMEDIC-2 study). TDR: None declared. CS: None declared. JS: None declared. KS: Speakers fees and travel grants from Bard Medical. AC: Speakers fees and travel grants from Bard Medical.
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