Invasive meningococcal disease-induced myocarditis in critically ill adult patients: initial presentation and long-term outcome
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Myocarditis lesions have been found in up to three-quarters of children and young adults dying from invasive meningococcal disease (IMD) with histopathological examinations identifying Neisseria meningitidis in the injured myocardium [1, 2]. These features strongly differ from the usual septic cardiomyopathy, in which neither myocardial necrosis nor the presence of bacteria in the heart are observed . Because the clinical data on IMD-induced myocarditis remain scarce, we aimed to describe the initial presentation and long-term outcome of IMD-induced myocarditis in critically ill adult patients.
We conducted a 12-year observational, retrospective, multicentric study in four French academic intensive care units (ICUs). The study received approval from our institutional review board. IMD was diagnosed in adults (>16 years old) when Neisseria meningitidiswas isolated from usually sterile fluids or tissues. Myocarditis diagnosis was retained, according to the position statement of the...
KeywordsLeft Ventricular Ejection Fraction Myocarditis Myocardial Necrosis Neisseria Meningitidis Elevated Troponin
Compliance with ethical standards
Conflicts of interest
The authors declare they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of our institutional research committee and with the 1964 Declaration of Helsinki and its later amendments. For this type of study formal consent was not required.