Intensive Care Medicine

, Volume 42, Issue 12, pp 1877–1887 | Cite as

Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit: the single-centre, blinded, randomised controlled OPTINIV trial

  • Samir Jaber
  • Marion Monnin
  • Mehdi Girard
  • Matthieu Conseil
  • Moussa Cisse
  • Julie Carr
  • Martin Mahul
  • Jean Marc Delay
  • Fouad Belafia
  • Gérald Chanques
  • Nicolas Molinari
  • Audrey De Jong
Seven-Day Profile Publication



High-flow nasal cannula oxygen (HFNC) has the potential to provide apnoeic oxygenation. We decided to assess in a proof-of-concept study whether the addition of HFNC to non-invasive ventilation (NIV) could reduce oxygen desaturation during intubation, compared with NIV alone for preoxygenation, in severely hypoxaemic intensive care unit (ICU) patients with respiratory failure.


We conducted a randomised, controlled, single-centre trial with assessor-blinded outcome assessment in patients admitted to the ICU. Hypoxaemic patients requiring orotracheal intubation for respiratory failure were randomised to receive preoxygenation using HFNC [flow = 60 L/min, fraction of inspired oxygen (FiO2) = 100 %] combined with NIV (pressure support = 10 cmH2O, positive end-expiratory pressure = 5 cmH2O, FiO2 = 100 %) in the intervention group or NIV alone in the reference group prior to intubation. The primary outcome was the lowest oxygen saturation (SpO2) during the intubation procedure. Secondary outcomes were intubation-related complications and ICU mortality.


Between July 2015 and February 2016, we randomly assigned 25 and 24 patients to the intervention and reference groups, respectively. In both groups the main reasons for respiratory failure were pneumonia and ARDS. During the intubation procedure, the lowest SpO2 values were significantly higher in the intervention group than in the reference group [100 (95–100) % vs. 96 (92–99) %, p = 0.029]. After exclusion of two patients from analysis for protocol violation, no (0 %) patients in the intervention group and five (21 %) patients in the reference group had SpO2 below 80 % (p = 0.050). We recorded no significant difference between the groups in intubation-related complications or ICU mortality.


A novel strategy for preoxygenation in hypoxaemic patients, adding HFNC for apnoeic oxygenation to NIV prior to orotracheal intubation, may be more effective in reducing the severity of oxygen desaturation than the reference method using NIV alone.


Apnoeic oxygenation Preoxygenation High-flow nasal cannula oxygen Non-invasive ventilation Intubation Hypoxaemia 


Compliance with ethical standards

Conflicts of interests

Dr. Jaber reports receiving consulting fees from Drager, Hamilton, Maquet, and Fisher & Paykel. No potential conflict of interest relevant to this article was reported for the other authors.

Role of the funding source

The study is an investigator-initiated trial. Study promoter is Montpellier University Hospital, Montpellier, France. There is no industry support or involvement in the trial. The funder had no role in the design or conduct of the study, data collection, analysis or interpretation, the writing of the report or in the decision to submit for publication. The corresponding author had full access to all of the data and the final responsibility to submit for publication.

Protocol with consort details

Full protocol was published in BMJ Open Access [25] and follows Consort 2010 guidelines.

Ethics committee approval

The Institutional Review Board of the University Hospital of Montpellier (France) approved the trial. On 13 May 2015, the study was approved by a central ethics committee (Comité de Protection des Personnes Sud-Méditerranée IV, Montpellier, France) with the registration number IDRCB 2015-A00708-41. The OPTINIV study was conducted in accordance with the Declaration of Helsinki and was registered at with trial identification number NCT02530957.

Supplementary material

134_2016_4588_MOESM1_ESM.docx (908 kb)
Supplementary material 1 (DOCX 907 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2016

Authors and Affiliations

  • Samir Jaber
    • 1
    • 2
  • Marion Monnin
    • 1
  • Mehdi Girard
    • 1
  • Matthieu Conseil
    • 1
  • Moussa Cisse
    • 1
  • Julie Carr
    • 1
  • Martin Mahul
    • 1
  • Jean Marc Delay
    • 1
  • Fouad Belafia
    • 1
  • Gérald Chanques
    • 1
    • 2
  • Nicolas Molinari
    • 3
  • Audrey De Jong
    • 1
    • 2
  1. 1.Department of Anesthesiology and Critical Care Medicine B (DAR B), Saint-Eloi HospitalUniversity Teaching Hospital of MontpellierMontpellierFrance
  2. 2.INSERM U1046, CNRS UMR 9214MontpellierFrance
  3. 3.Department of StatisticsUniversity of Montpellier Lapeyronie HospitalMontpellierFrance

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