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Intensive Care Medicine

, Volume 42, Issue 12, pp 2077–2079 | Cite as

Understanding circulatory failure in sepsis

  • Andreas Bloch
  • David Berger
  • Jukka TakalaEmail author
Understanding the Disease

Introduction

Septic shock or acute circulatory failure in sepsis causes a mismatch between tissue perfusion and metabolic demands. The heart, the vasculature and alterations in various tissue and cellular functions are involved in the pathophysiology. The clinical presentation can be highly variable, changes over time and is modified by preceding and concomitant treatment and comorbidities. The clinical hallmarks of septic shock are signs of tissue hypoperfusion, hypotension or need for vasopressors to prevent hypotension, despite adequate fluid resuscitation. Signs of tissue hypoperfusion vary and can include impaired capillary perfusion, oliguria, elevated blood lactate and altered mentation. The blood pressure level that is clinically relevant varies between patients, and “adequate” fluid resuscitation is highly subjective. Therefore, septic shock defies explicit, objective definitions, as shown by the current debate around attempts to define it [1, 2]. Nevertheless, increasing...

Keywords

Septic Shock Stressed Volume Right Ventricular Venous Return Pulse Pressure Variation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Compliance with ethical standards

Conflicts of interest

The authors do not have any conflict of interest regarding this article.

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Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2016

Authors and Affiliations

  1. 1.Department of Intensive Care MedicineInselspital, Bern University Hospital, University of BernBernSwitzerland

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