Intensive Care Medicine

, Volume 43, Issue 1, pp 91–93 | Cite as

Understanding the Haldane effect

Understanding the Disease

References

  1. 1.
    Christiansen J, Douglas CG, Haldane JS (1914) The absorption and dissociation of carbon dioxide by human blood. J Physiol 48:244–271CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Zhang H, Vincent JL (1993) Arteriovenous differences in PCO2 and pH are good indicators of critical hypoperfusion. Am Rev Respir Dis 148:867–871CrossRefPubMedGoogle Scholar
  3. 3.
    Dres M, Monnet X, Teboul JL (2012) Hemodynamic management of cardiovascular failure by using PCO(2) venous-arterial difference. J Clin Monit Comput 26:367–374CrossRefPubMedGoogle Scholar
  4. 4.
    Bakker J, Vincent JL, Gris P, Leon M, Coffernils M, Kahn RJ (1992) Veno-arterial carbon dioxide gradient in human septic shock. Chest 101:509–515CrossRefPubMedGoogle Scholar
  5. 5.
    Mekontso-Dessap A, Castelain V, Anguel N, Bahloul M, Schauvliege F, Richard C, Teboul JL (2002) Combination of venoarterial PCO2 difference with arteriovenous O2 content difference to detect anaerobic metabolism in patients. Intensive Care Med 28:272–277CrossRefPubMedGoogle Scholar
  6. 6.
    Vallet B, Teboul JL, Cain S, Curtis S (2000) Venoarterial CO(2) difference during regional ischemic or hypoxic hypoxia. J Appl Physiol 89:1317–1321PubMedGoogle Scholar
  7. 7.
    Jakob SM, Groeneveld ABJ, Teboul JL (2015) Venous–arterial CO2 to arterial–venous O2 difference ratio as a resuscitation target in shock states? Intensive Care Med 41:936–938CrossRefPubMedGoogle Scholar
  8. 8.
    Giovannini I, Chiarla C, Boldrini G, Castagneto M (1993) Calculation of venoarterial CO2 concentration difference. J Appl Physiol 74:959–964PubMedGoogle Scholar
  9. 9.
    Mallat J, Benzidi Y, Salleron J, Lemyze M, Gasan G, Vangrunderbeeck N, Pepy F, Tronchon L, Vallet B, Thevenin D (2014) Time course of central venous-to-arterial carbon dioxide tension difference in septic shock patients receiving incremental doses of dobutamine. Intensive Care Med 40:404–411CrossRefPubMedGoogle Scholar
  10. 10.
    Ospina-Tascón GA, Umaña M, Bermúdez WF, Bautista-Rincón DF, Valencia JD, Madriñán HJ, Hernandez G, Bruhn A, Arango-Dávila C, De Backer D (2016) Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock? Intensive Care Med 42:211–221CrossRefPubMedGoogle Scholar
  11. 11.
    Ospina-Tascon GA, Bautista-Rincon DF, Umana M, Tafur JD, Gutierrez A, Garcia AF, Bermudez W, Granados M, Arango-Davila C, Hernandez G (2013) Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock. Crit Care 17:R294CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Vallee F, Vallet B, Mathe O, Parraguette J, Mari A, Silva S, Samii K, Fourcade O, Genestal M (2008) Central venous-to-arterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock? Intensive Care Med 34:2218–2225CrossRefPubMedGoogle Scholar
  13. 13.
    Citerio G, Bakker J, Bassetti M, Benoit D, Cecconi M, Curtis JR, Doig GS, Herridge M, Jaber S, Joannidis M, Papazian L, Perner A, Peters MJ, Singer P, Smith M, Soares M, Torres A, Vieillard-Baron A, Timsit JF, Azoulay E (2015) Year in review in Intensive Care Medicine 2014: I. Cardiac dysfunction and cardiac arrest, ultrasound, neurocritical care, ICU-acquired weakness, nutrition, acute kidney injury, and miscellaneous. Intensive Care Med 41:179–191CrossRefPubMedCentralGoogle Scholar
  14. 14.
    Vallet B, Pinsky MR, Cecconi M (2013) Resuscitation of patients with septic shock: please “mind the gap”! Intensive Care Med 39:1653–1655CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Monnet X, Julien F, Ait-Hamou N, Lequoy M, Gosset C, Jozwiak M, Persichini R, Anguel N, Richard C, Teboul JL (2013) Lactate and veno-arterial carbon dioxide difference/arterial-venous oxygen difference ratio, but not central venous oxygen saturation, predict increase in oxygen consumption in fluid responders. Crit Care Med 41:1412–1420CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2016

Authors and Affiliations

  1. 1.Service de Réanimation MédicaleHôpital de Bicêtre, Hôpitaux Universitaires Paris-SudLe Kremlin-BicêtreFrance
  2. 2.Faculté de Médecine Paris-SudUniv Paris-Sud, Inserm UMR S_999Le Kremlin-BicêtreFrance
  3. 3.Department of AnesthesiologyUniversity Medical Center GroningenGroningenThe Netherlands
  4. 4.University of GroningenGroningenThe Netherlands

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