Intensive Care Medicine

, Volume 42, Issue 5, pp 942–943 | Cite as

Long-term survival after extracorporeal life support in children with neutropenic sepsis

  • Sile Smith
  • Warwick Butt
  • Derek Best
  • Graeme MacLarenEmail author

Dear Editor,

Extracorporeal life support (ECLS) is an established intervention for paediatric patients with cardiorespiratory failure failing conventional therapy. Malignancy was historically regarded as a contraindication to ECLS, but analyses of the Extracorporeal Life Support Organization registry demonstrated that ECLS could be appropriate in carefully selected patients [1, 2]. Neutropenic sepsis that complicates chemotherapy has also been regarded as a contraindication to ECLS because of the uncertain long-term prognosis and vulnerability of these children to nosocomial infection. However, there are minimal data on the use of ECLS for this indication. We reviewed our institutional experience of children with febrile neutropenia receiving ECLS.

The study was approved by the institutional review board and waiver of informed consent was granted. A retrospective chart review was conducted on all paediatric patients with known malignancy commenced on ECLS at the Royal Children’s...


Hospital Discharge Renal Replacement Therapy Febrile Neutropenia Continuous Renal Replacement Therapy Neutropenic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with ethical standards

Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2015

Authors and Affiliations

  • Sile Smith
    • 1
  • Warwick Butt
    • 1
    • 2
  • Derek Best
    • 1
  • Graeme MacLaren
    • 1
    • 2
    • 3
    Email author
  1. 1.Paediatric Intensive Care UnitThe Royal Children’s HospitalMelbourneAustralia
  2. 2.Department of PaediatricsThe University of MelbourneParkvilleAustralia
  3. 3.Cardiothoracic Intensive Care UnitNational University Health SystemSingaporeSingapore

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