Biomarkers of ARDS: what’s new?
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Despite hundreds of studies of biomarkers in the acute respiratory distress syndrome (ARDS), there are no biomarkers of ARDS in use in clinical practice . A recent meta-analysis highlights some of the limitations of current studies: small sample sizes, inadequate and inconsistent controls, and lack of large validation studies for many biomarkers . Nevertheless, recent progress in several areas of biomarker research, including advances in the development of point-of-care testing technologies, has the potential to transform the application of biomarkers to clinical ARDS and may soon lead to the use of biomarkers at the bedside for diagnosis, risk stratification, and molecular phenotyping.
One area where there has been significant progress is in the identification of biomarkers with greater specificity for ARDS. Studies of single candidate biomarkers have yet to yield a troponin-like biomarker specific for lung injury that could be used clinically for diagnosis, severity assessment,...
KeywordsAcute Lung Injury Acute Respiratory Distress Syndrome Latent Class Analysis Acute Respiratory Distress Syndrome Patient Alveolar Fluid Clearance
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Conflicts of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
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