Early lactate clearance-guided therapy in patients with sepsis: a meta-analysis with trial sequential analysis of randomized controlled trials
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Sepsis represents a global problem with high economic burden for health care systems. Since 2002, the Surviving Sepsis Campaign has recommended early quantitative resuscitation for patients with severe sepsis and septic shock with a recent update . However, the optimal goals for quantitative resuscitation remain uncertain. Lactate clearance, defined by the change of lactate levels between two points in time, as a more rapid and less costly parameter, has the potential to be such a promising goal for quantitative resuscitation. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of early lactate clearance-guided therapy on mortality and other outcomes in patients with sepsis.
We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials to identify RCTs that evaluated the effect of early lactate clearance-guided therapy on clinical outcomes in adults with sepsis. The search terms used were “lactate clearance”, and...
KeywordsElectronic Supplementary Material Severe Sepsis Intensive Care Unit Stay Survive Sepsis Campaign Lactate Clearance
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Conflicts of interest
The authors declare to have no possible conflict of interest.