Understanding vitamin D deficiency in intensive care patients
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Vitamin D deficiency (VDD) is a well-established cause of musculoskeletal disease. Over the past few decades a growing body of literature has changed our understanding of vitamin D and proposed roles in infectious, immunologic, neurologic, cardiovascular, and respiratory disorders . More recently VDD has been hypothesized as a modifiable risk factor for poor outcome in the hospitalized and specifically the ICU patient [1, 2, 3].
Prevalence of vitamin D deficiency and risk factors in intensive care
Circulating 25-hydroxyvitamin D [25(OH)D] is the accepted marker for evaluating vitamin D status. Although some controversy remains, there are generally accepted thresholds for defining vitamin D sufficiency (75 nmol/L), deficiency (50 nmol/L), and severe deficiency (30 nmol/L) . Applying the 50 nmol/L threshold, ICUs worldwide have reported VDD rates ranging from 60 to 100 % [3, 4, 5, 6].
KeywordsCritical Illness Health Resource Utilization Multicenter RCTs Nongenomic Pathway Initial Enteral
Conflicts of interest
The authors report no conflict of interest.
- 3.McNally JD, Menon K (2013) Vitamin D deficiency in surgical congenital heart disease: prevalence and relevance. Transl Pediatr 2(3):99–111Google Scholar
- 7.McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al-Dirbashi OY, Girolamo T, Maharajh G, Doherty DR (2013) Impact of anesthesia and surgery for congenital heart disease on the vitamin D status of infants and children: a prospective longitudinal study. Anesthesiology 119:71–80CrossRefPubMedGoogle Scholar