Intensive Care Medicine

, Volume 41, Issue 3, pp 517–520 | Cite as

Understanding ARDS-associated fibroproliferation

  • Gianfranco Umberto MeduriEmail author
  • Mahmoud A. Eltorky
Understanding the Disease

Understanding ARDS-associated lung fibroproliferation requires viewing (1) ARDS as a disease of multifactorial etiology and not as a syndrome and (2) fibroproliferation as an integral part of the disease process and not as a separate temporal component. Although the term “syndrome” (aggregate of symptoms and signs) was applied in its original description [1], ARDS meets all the constitutive elements of a disease process [2]. Translational clinical research has constructed—through a “holistic” level of inquiry—a pathophysiological model of ARDS that fits the pathogenesis (biology—core stratum) with morphological (histology—intermediate stratum) and clinical (physiology—outer stratum) findings observed during the course of the disease [3].

Fibroproliferation is an integral component of the tissue defense response (TDR), a stereotypical host reaction to contain—at the tissue level—insults and repair any resultant injury. The TDR (constituent of innate immunity) consists of a highly...


Diffuse Alveolar Damage Pulmonary Lobule Alveolar Duct Respiratory Bronchiole Vascular Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This material is the result of work supported with the resources and use of facilities at the Memphis VA Medical Center. The contents of this commentary do not represent the views of the US Department of Veterans Affairs or the United States Government.

Conflicts of interest

Both authors declare no conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM (outside the USA) 2014

Authors and Affiliations

  • Gianfranco Umberto Meduri
    • 1
    Email author
  • Mahmoud A. Eltorky
    • 2
  1. 1.Division of Pulmonary, Critical Care, and Sleep Medicine, Department of MedicineMemphis Veterans Affairs Medical CenterMemphisUSA
  2. 2.Surgical Pathology Division, Department of PathologyUniversity of Texas Medical BranchGalvestonUSA

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