Understanding ARDS-associated fibroproliferation
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Understanding ARDS-associated lung fibroproliferation requires viewing (1) ARDS as a disease of multifactorial etiology and not as a syndrome and (2) fibroproliferation as an integral part of the disease process and not as a separate temporal component. Although the term “syndrome” (aggregate of symptoms and signs) was applied in its original description , ARDS meets all the constitutive elements of a disease process . Translational clinical research has constructed—through a “holistic” level of inquiry—a pathophysiological model of ARDS that fits the pathogenesis (biology—core stratum) with morphological (histology—intermediate stratum) and clinical (physiology—outer stratum) findings observed during the course of the disease .
Fibroproliferation is an integral component of the tissue defense response (TDR), a stereotypical host reaction to contain—at the tissue level—insults and repair any resultant injury. The TDR (constituent of innate immunity) consists of a highly...
KeywordsDiffuse Alveolar Damage Pulmonary Lobule Alveolar Duct Respiratory Bronchiole Vascular Surface
This material is the result of work supported with the resources and use of facilities at the Memphis VA Medical Center. The contents of this commentary do not represent the views of the US Department of Veterans Affairs or the United States Government.
Conflicts of interest
Both authors declare no conflicts of interest.
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