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Intensive Care Medicine

, Volume 41, Issue 3, pp 551–552 | Cite as

Sepsis: needs for defining severity

  • Luciano GattinoniEmail author
  • V. Marco Ranieri
  • Antonio Pesenti
Letter

Keywords

Oxygen Saturation Sepsis Severity Systemic Inflammatory Response Syndrome Acute Respiratory Distress Syndrome Septic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflicts of interest

LG reports grant support from the Italian Medicines Agency (AIFA, Agenzia Italiana del Farmaco) while conducting the ALBIOS study as well as speaker's fees from Grifols, Kedrion and Baxter and Advisory Board honoraria from Grifols outside the submitted work. VMR reports consultancies for MAQUET and a grant for the FARON_FPCLI001 clinical study with FP-1201 in acute lung injuries outside the submitted work. AP reports grant support from the Italian Medicines Agency (AIFA, Agenzia Italiana del Farmaco) while conducting the ALBIOS study, grant support from Chiesi Farmaceutici, consultancies for Maquet and Novalung, and fees for mechanical ventilation courses from Draeger outside the submitted work. The authors state that the subject discussed in the submitted manuscript was not dependent on financial support.

References

  1. 1.
    Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M et al (2014) Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med 370:1412–1421CrossRefPubMedGoogle Scholar
  2. 2.
    Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N et al (2014) High versus low blood-pressure target in patients with septic shock. N Engl J Med 370:1583–1593CrossRefPubMedGoogle Scholar
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    Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S et al (2014) Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med 371:1381–1391CrossRefPubMedGoogle Scholar
  4. 4.
    Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F et al (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:1683–1693CrossRefPubMedGoogle Scholar
  5. 5.
    The ARISE Investigators and the ANZICS Clinical Trials Group (2014) Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371:1496–1506CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2014

Authors and Affiliations

  • Luciano Gattinoni
    • 1
    • 4
    Email author
  • V. Marco Ranieri
    • 2
  • Antonio Pesenti
    • 3
  1. 1.Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà GrandaOspedale Maggiore PoliclinicoMilanItaly
  2. 2.Department of Anesthesia and Intensive Care Medicine, S.Giovanni Battista Molinette HospitalUniversity of TurinTurinItaly
  3. 3.Dipartimento di Scienze della SaluteUniversità degli Studi di Milano BicoccaMilanItaly
  4. 4.Dipartimento di Fisiopatologia Medico-Chirurgica e dei TrapiantiUniversità degli Studi di MilanoMilanItaly

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