Intensive Care Medicine

, Volume 41, Issue 2, pp 239–247 | Cite as

Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage

  • Sirat Khan
  • Ross Davenport
  • Imran Raza
  • Simon Glasgow
  • Henry D. De’Ath
  • Pär I. Johansson
  • Nicola Curry
  • Simon Stanworth
  • Christine Gaarder
  • Karim Brohi



To determine the effectiveness of blood component therapy in the correction of trauma-induced coagulopathy during hemorrhage.


Severe hemorrhage remains a leading cause of mortality in trauma. Damage control resuscitation strategies target trauma-induced coagulopathy (TIC) with the early delivery of high-dose blood components such as fresh frozen plasma (FFP) and platelet transfusions. However, the ability of these products to correct TIC during hemorrhage and resuscitation is unknown.


This was an international prospective cohort study of bleeding trauma patients at three major trauma centers. A blood sample was drawn immediately on arrival and after 4, 8 and 12 packed red blood cell (PRBC) transfusions. FFP, platelet and cryoprecipitate use was recorded during these intervals. Samples were analyzed for functional coagulation and procoagulant factor levels.


One hundred six patients who received at least four PRBC units were included. Thirty-four patients (32 %) required a massive transfusion. On admission 40 % of patients were coagulopathic (ROTEM CA5 ≤ 35 mm). This increased to 58 % after four PRBCs and 81 % after eight PRBCs. On average all functional coagulation parameters and procoagulant factor concentrations deteriorated during hemorrhage. There was no clear benefit to high-dose FFP therapy in any parameter. Only combined high-dose FFP, cryoprecipitate and platelet therapy with a high total fibrinogen load appeared to produce a consistent improvement in coagulation.


Damage control resuscitation with standard doses of blood components did not consistently correct trauma-induced coagulopathy during hemorrhage. There is an important opportunity to improve TIC management during damage control resuscitation.


Damage control Resuscitation Plasma Transfusion 



Funded in part by the National Institute for Health Research (UK) Program Grant for Applied Research (RP-PG-0407-10036).

Conflicts of interest

TEM Innovations (ROTEM): unrestricted support in the form of equipment and reagents for the ACIT study. SK and RD have received honoraria as invited speakers.

Supplementary material

134_2014_3584_MOESM1_ESM.docx (60 kb)
Supplementary material 1 (DOCX 59 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2014

Authors and Affiliations

  • Sirat Khan
    • 1
  • Ross Davenport
    • 1
  • Imran Raza
    • 1
  • Simon Glasgow
    • 1
  • Henry D. De’Ath
    • 1
  • Pär I. Johansson
    • 4
  • Nicola Curry
    • 2
  • Simon Stanworth
    • 2
  • Christine Gaarder
    • 3
  • Karim Brohi
    • 1
  1. 1.Centre for Trauma Sciences, Blizard Institute, Barts and the London School of MedicineQueen Mary University of LondonLondonUK
  2. 2.NHS Blood and TransplantJohn Radcliffe HospitalOxfordUK
  3. 3.Department of TraumatologyOslo University Hospital UllevalOsloNorway
  4. 4.Section for Transfusion Medicine, Capital Region Blood Bank, RigshospitaletUniversity of CopenhagenCopenhagenDenmark

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