Understanding organ dysfunction in Ebola virus disease
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Ebola viruses are single-stranded RNA filoviruses which are maintained in nature in fruit bats . The genus includes five strains that are clinically distinguished by their usual geographic location and severity of disease in humans. The Reston strain does not appear to cause human disease, and asymptomatic human infections can also occur with other strains. The current West African outbreak is caused by the Zaire strain,which is typically associated with mortality rates of 50–90 % [2, 3]. This short review summarises knowledge about the pathogenesis of organ dysfunction in Ebola virus disease (EVD).
KeywordsDisseminate Intravascular Coagulation Capillary Leak Syndrome Poor Prognostic Sign Inadequate Oral Intake Haemorrhagic Manifestation
Drs Fletcher and Fowler both provide assistance to Ebola Treatment Centres in West Africa, supported by the World Health Organization. Dr Fletcher receives support from the Wellcome Trust and from the Ministry of Defence. Dr Fowler is a clinician scientist of the Heart and Stroke Foundation (Ontario, Canada). Dr Beeching is partially supported by a National Institute of Health Research grant to the Health Protection Research Unit in Emerging and Zoonotic Infections, a collaboration between the University of Liverpool, Liverpool School of Tropical Medicine and Public Health England. Views expressed are those of the authors.
Conflicts of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
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