Acute ischemic stroke in the ICU: to admit or not to admit?
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Acute ischemic stroke (AIS) is an important health-care problem worldwide, and a significant cause of disability as well as mortality. The incidence of AIS is expected to increase in the future, because the majority of AIS are caused by cardio-embolic disorders and atherosclerosis, typical for the ageing population.
Only two interventions in small subsets of patients have been demonstrated to improve the outcome of AIS patients. The single most important intervention to alter the natural history of AIS and improve the patients’ functional outcome is the timely administration of a thrombolytic agent (intravenous rt-PA) in the appropriate patient within the narrow 4.5-h window . Endovascular therapy represents an alternative therapy to intravenous rt-PA in those who are not candidates for intravenous rt-PA, but has no advantage over intravenous rt-PA . Hemispheric decompression in patients less than 60 years of age with malignant middle cerebral artery territory (MCA) infarction and space-occupying brain oedema has been demonstrated to improve outcome. This result was confirmed in an individual patient meta-analysis, demonstrating a marked improvement in neurological recovery and survival . For the age group older than 60 years of age with malignant MCA infarction, who are over-represented in the AIS patient group, the recently published DESTINY II trial was able to demonstrate that decompression was also able to reduce mortality, but not influence the proportion of patients with severe disability . Despite initial promise, neuroprotective agents have failed to show a benefit in the management of AIS , as have tight glycaemic control , high dose albumin  and the use of anti-hypertensive agents [8, 9].
The lack of data on the outcome benefit of specific therapeutic interventions to improve the outcome of the majority of patients suffering from AIS certainly does not imply that physicians should adopt a fatalistic approach when managing these patients. A number of well-conducted clinical trials have demonstrated that the mortality and functional recovery of patients following a stroke are significantly improved when these patients are cared for in a specialized stroke unit as compared to a general medical ward [19, 20]. These units provide specialized nursing care and a well-organized multidisciplinary rehabilitation program. Stroke unit care reduces the medical complications in these patients and allows for earlier and more intense rehabilitation.
In contrast to this, specific stroke ICUs were abandoned in the 1970s after it was demonstrated that such units had very little impact on the outcome of patients following a stroke. Nevertheless, a proportion of patients who suffer from stroke may benefit from admission to the ICU. Endotracheal intubation and mechanical ventilation should be reserved for patients with reversible respiratory failure who are likely to have a good prognosis for a functional recovery, e.g. in the treatment and prevention of aspiration pneumonia due to temporal loss of bulbar function, occurring in 37–78 % of stroke patients . Large MCA strokes who may require decompressive craniectomy, regardless of their age [3, 4], and space-occupying cerebellar infarctions accessible to a prompt surgical decompression  are a clear indication for ICU admission. In some cases, the management of blood pressure, or seizures, might necessitate an ICU admission.
Further research should focus on the use of validated stroke severity scoring systems such as the NIH Stroke Scale (NIHSS) or the Triage Stroke Panel (MMX), taking into account the initial clinical evolution of these patients , to identify those patients who will benefit from ICU referral. It is clear that aggressive medical measures in deeply comatose patients, with a low probability of a favourable outcome are a form of non-beneficial care, which will only increase the burden on patients, families and the health-care system. The paradigm of “less may be more” would appear to be appropriate for these patients .
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