Intensive Care Medicine

, Volume 39, Issue 5, pp 977–978 | Cite as

Pharmacokinetics of oseltamivir carboxylate in critically ill patients: each patient is unique

  • W. KromdijkEmail author
  • M. A. Sikma
  • M. P. H. van den Broek
  • J. H. Beijnen
  • A. D. R. Huitema
  • D. W. de Lange

Dear Editor,

Patients infected with the 2009 H1N1 pandemic influenza virus often develop severe viral pneumonia with acute respiratory distress syndrome (ARDS) and multiple organ failure. High-dose oseltamivir (≥150 mg twice daily) has been advocated as optimal treatment [1]. However, the scientific evidence for this advice is lacking thus far [2]. Therefore, we explored the pharmacokinetics of oseltamivir and its active metabolite oseltamivir carboxylate in critically ill patients with H1N1 pandemic influenza following different dosing regimens.

All patients with H1N1 pandemic influenza admitted to the ICU of the University Medical Center Utrecht were eligible for inclusion. Patients received oseltamivir at a dose determined by their treating physician, and blood samples were drawn at t = 0, 1, 2, 3, 4 and 8 h on day three of treatment. Oseltamivir and oseltamivir carboxylate plasma concentrations were determined by HPLC–MS/MS [3]. The area under the concentration–time curve from 0...


Acute Respiratory Distress Syndrome Aspergillosis Oseltamivir Extracorporeal Membrane Oxygenation Hairy Cell Leukemia 
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Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2013

Authors and Affiliations

  • W. Kromdijk
    • 1
    Email author
  • M. A. Sikma
    • 2
  • M. P. H. van den Broek
    • 3
  • J. H. Beijnen
    • 1
    • 4
  • A. D. R. Huitema
    • 1
  • D. W. de Lange
    • 2
  1. 1.Department of Pharmacy & PharmacologySlotervaart HospitalAmsterdamThe Netherlands
  2. 2.Intensive Care Center and Dutch Poison Information CenterUniversity Medical CenterUtrechtThe Netherlands
  3. 3.Department of Clinical PharmacyUniversity Medical CenterUtrechtThe Netherlands
  4. 4.Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical PharmacologyUtrecht UniversityUtrechtThe Netherlands

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