Intensive Care Medicine

, Volume 39, Issue 5, pp 977–978 | Cite as

Pharmacokinetics of oseltamivir carboxylate in critically ill patients: each patient is unique

  • W. Kromdijk
  • M. A. Sikma
  • M. P. H. van den Broek
  • J. H. Beijnen
  • A. D. R. Huitema
  • D. W. de Lange
Correspondence

References

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    WHO (2009) Guidelines for pharmacological management of pandemic (H1N1) 2009 influenza and other influenza viruses. Available at: http://www.who.int/csr/resources/publications/swineflu/h1n1_use_antivirals_20090820/en/index.html. Accessed 29 January 2013
  2. 2.
    Ariano RE, Sitar DS, Zelenitsky SA, Zarychanski R, Pisipati A, Ahern S, Kanji S, Rello J, Kumar A (2010) Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza. CMAJ 182(4):357–363PubMedCrossRefGoogle Scholar
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    Kromdijk W, Rosing H, van den Broek MP, Beijnen JH, Huitema AD (2012) Quantitative determination of oseltamivir and oseltamivir carboxylate in human fluoride EDTA plasma including the ex vivo stability using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 891–892:57–63PubMedGoogle Scholar
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    Widmer N, Meylan P, Ivanyuk A, Aouri M, Decosterd LA, Buclin T (2010) Oseltamivir in seasonal, avian H5N1 and pandemic 2009 A/H1N1 influenza: pharmacokinetic and pharmacodynamic characteristics. Clin Pharmacokinet 49(11):741–765PubMedCrossRefGoogle Scholar
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    Anderson GD (2005) Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 44(10):989–1008PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2013

Authors and Affiliations

  • W. Kromdijk
    • 1
  • M. A. Sikma
    • 2
  • M. P. H. van den Broek
    • 3
  • J. H. Beijnen
    • 1
    • 4
  • A. D. R. Huitema
    • 1
  • D. W. de Lange
    • 2
  1. 1.Department of Pharmacy & PharmacologySlotervaart HospitalAmsterdamThe Netherlands
  2. 2.Intensive Care Center and Dutch Poison Information CenterUniversity Medical CenterUtrechtThe Netherlands
  3. 3.Department of Clinical PharmacyUniversity Medical CenterUtrechtThe Netherlands
  4. 4.Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical PharmacologyUtrecht UniversityUtrechtThe Netherlands

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