Skip to main content

Advertisement

SpringerLink
Log in

Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients

  • Special Article
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

Purpose

Colloids are administered to more patients than crystalloids, although recent evidence suggests that colloids may possibly be harmful in some patients. The European Society of Intensive Care Medicine therefore assembled a task force to compile consensus recommendations based on the current best evidence for the safety and efficacy of the currently most frequently used colloids—hydroxyethyl starches (HES), gelatins and human albumin.

Methods

Meta-analyses, systematic reviews and clinical studies of colloid use were evaluated for the treatment of volume depletion in mixed intensive care unit (ICU), cardiac surgery, head injury, sepsis and organ donor patients. Clinical endpoints included mortality, kidney function and bleeding. The relevance of concentration and dosage was also assessed. Publications from 1960 until May 2011 were included. The quality of available evidence and strength of recommendations were based on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.

Recommendations and conclusions

We recommend not to use HES with molecular weight ≥200 kDa and/or degree of substitution >0.4 in patients with severe sepsis or risk of acute kidney injury and suggest not to use 6% HES 130/0.4 or gelatin in these populations. We recommend not to use colloids in patients with head injury and not to administer gelatins and HES in organ donors. We suggest not to use hyperoncotic solutions for fluid resuscitation. We conclude and recommend that any new colloid should be introduced into clinical practice only after its patient-important safety parameters are established.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Notes

  1. Increased risk of AKI was defined by a recent consensus conference as advanced age, sepsis, cardiovascular surgery, contrast nephropathy [64].

References

  1. Shafer SL (2010) Notice of retraction. Anesth Analg 111:1567

    Article  PubMed  Google Scholar 

  2. Shafer SL (2011) Shadow of doubt. Anesth Analg 112:498–500

    Article  PubMed  Google Scholar 

  3. Perel P, Roberts I (2011) Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 3:CD000567

    Google Scholar 

  4. Bunn F, Trivedi D, Ashraf S (2011) Colloid solutions for fluid resuscitation. Cochrane Database Syst Rev 3:CD001319

    Google Scholar 

  5. Delaney AP, Dan A, McCaffrey J, Finfer S (2011) The role of albumin as a resuscitation fluid for patients with sepsis: a systematic review and meta-analysis. Crit Care Med 39:386–391

    Article  PubMed  CAS  Google Scholar 

  6. Hartog CS, Kohl M, Reinhart K (2011) A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: safety not adequately addressed. Anesth Analg 112:635–645

    Article  PubMed  CAS  Google Scholar 

  7. Reinhart K, Takala J (2011) Hydroxyethyl starches: what do we still know? Anesth Analg 112:507–511

    Article  PubMed  Google Scholar 

  8. Finfer S, Liu B, Taylor C, Bellomo R, Billot L, Cook D, Du B, McArthur C, Myburgh J, Investigators TS (2010) Resuscitation fluid use in critically ill adults: an international cross sectional study in 391 intensive care units. Crit Care 14:R185

    Article  PubMed  Google Scholar 

  9. Schortgen F, Deye N, Brochard L (2004) Preferred plasma volume expanders for critically ill patients: results of an international survey. Intensive Care Med 30:2222–2229

    Article  PubMed  Google Scholar 

  10. [No authors listed] (2004) Evidence-based colloid use in the critically ill: American Thoracic Society Consensus Statement. Am J Respir Crit Care Med 170:1247–1259

    Google Scholar 

  11. Brochard L, Abroug F, Brenner M, Broccard AF, Danner RL, Ferrer M, Laghi F, Magder S, Papazian L, Pelosi P, Polderman KH (2010) An official ATS/ERS/ESICM/SCCM/SRLF statement: prevention and management of acute renal failure in the ICU patient: an international consensus conference in intensive care medicine. Am J Respir Crit Care Med 181:1128–1155

    Article  PubMed  Google Scholar 

  12. Joannidis M, Druml W, Forni LG, Groeneveld AB, Honore P, Oudemans-van Straaten HM, Ronco C, Schetz MR, Woittiez AJ (2009) Prevention of acute kidney injury and protection of renal function in the intensive care unit. Expert opinion of the Working Group for Nephrology. ESICM. Intensive Care Med 36:392–411

    Article  Google Scholar 

  13. Powell-Tuck J, Gosling P, Lobo DN, Allison S, Carlson GL, Gore M, Lewington AJ, Pearse RM, Mythen MG (2008) British Consensus Guidelines on Intravenous Fluid Therapy for Adult Surgical Patients (GIFTASUP). 2008. London: NHS National Library of Health. Available at http://www.ics.ac.uk/downloads/2008112340_GIFTASUP%20FINAL_31-10-08.pdf

  14. Liu B, Finfer S (2009) Intravenous fluids in adults undergoing surgery. BMJ 338:b2418

    Article  PubMed  Google Scholar 

  15. Dretzke J, Sandercock J, Bayliss S, Burls A (2004) Clinical effectiveness and cost-effectiveness of prehospital intravenous fluids in trauma patients. Health Technol Assess 8:iii, 1–103

    Google Scholar 

  16. Heier HE, Bugge W, Hjelmeland K, Soreide E, Sorlie D, Haheim LL (2006) Transfusion vs. alternative treatment modalities in acute bleeding: a systematic review. Acta Anaesthesiol Scand 50:920–931

    Article  PubMed  CAS  Google Scholar 

  17. Toomtong P, Suksompong S (2010) Intravenous fluids for abdominal aortic surgery. Cochrane Database Syst Rev: CD000991

  18. Dart AB, Mutter TC, Ruth CA, Taback SP (2010) Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function. Cochrane Database Syst Rev: CD007594

  19. Perel P, Roberts I (2009) Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev: CD000567

  20. [No authors listed] (1998) Department of Health and Human Services, Food and Drug Administration, 21 CFR Part 216 [Docket No. 98N-0655] List of Drug Products That Have Been Withdrawn or Removed From the Market for Reasons of Safety or Effectiveness. Federal Register: October 8, 1998 (Volume 63, Number 195) pages 54082-54089 Availabe via http://wwwfdagov/ohrms/dockets/98fr/100898btxt Assessed on 30 November 2010

  21. [No authors listed] (1998) Human albumin administration in critically ill patients: systematic review of randomised controlled trials. Cochrane Injuries Group Albumin Reviewers. BMJ 317:235–240

    Google Scholar 

  22. Alderson P, Bunn F, Lefebvre C, Li WP, Li L, Roberts I, Schierhout G (2002) Human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database Syst Rev: CD001208

  23. Wilkes MM, Navickis RJ (2001) Patient survival after human albumin administration. A meta-analysis of randomized, controlled trials. Ann Intern Med 135:149–164

    PubMed  CAS  Google Scholar 

  24. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R (2004) A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 350:2247–2256

    Article  PubMed  CAS  Google Scholar 

  25. Alderson P, Bunn F, Lefebvre C, Li WP, Li L, Roberts I, Schierhout G (2004) Human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database Syst Rev: CD001208

  26. Vincent JL, Navickis RJ, Wilkes MM (2004) Morbidity in hospitalized patients receiving human albumin: a meta-analysis of randomized, controlled trials. Crit Care Med 32:2029–2038

    Article  PubMed  CAS  Google Scholar 

  27. Vincent JL, Wilkes MM, Navickis RJ (2003) Safety of human albumin: serious adverse events reported worldwide in 1998–2000. Br J Anaesth 91:625–630

    Article  PubMed  CAS  Google Scholar 

  28. Barron ME, Wilkes MM, Navickis RJ (2004) A systematic review of the comparative safety of colloids. Arch Surg 139:552–563

    Article  PubMed  CAS  Google Scholar 

  29. Groeneveld AB, Navickis RJ, Wilkes MM (2011) Update on the comparative safety of colloids: a systematic review of clinical studies. Ann Surg 253:470–483

    Article  PubMed  Google Scholar 

  30. Zarychanski R, Turgeon AF, Fergusson DA, Cook DJ, Hebert P, Bagshaw SM, Monsour D, McIntyre LA (2009) Renal outcomes and mortality following hydroxyethyl starch resuscitation of critically ill patients: systematic review and meta-analysis of randomized trials. Open Med 3:E196–209

    PubMed  Google Scholar 

  31. Davidson IJ (2006) Renal impact of fluid management with colloids: a comparative review. Eur J Anaesthesiol 23:721–738

    Article  PubMed  CAS  Google Scholar 

  32. Sakr Y, Payen D, Reinhart K, Sipmann FS, Zavala E, Bewley J, Marx G, Vincent JL (2007) Effects of hydroxyethyl starch administration on renal function in critically ill patients. Br J Anaesth 98:216–224

    Article  PubMed  CAS  Google Scholar 

  33. Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, Newton CR, Levin M, Maitland K (2006) Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial. PLoS Clin Trials 1:e21

    Article  PubMed  Google Scholar 

  34. Finfer S, McEvoy S, Bellomo R, Liu B, McArthur C, Myburgh J, Norton R (2011) Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis. Intensive Care Med 37:86–96

    Article  PubMed  Google Scholar 

  35. Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364:2483–2495

    Article  PubMed  CAS  Google Scholar 

  36. Sedrakyan A, Gondek K, Paltiel D, Elefteriades JA (2003) Volume expansion with albumin decreases mortality after coronary artery bypass graft surgery. Chest 123:1853–1857

    Article  PubMed  Google Scholar 

  37. Russell JA, Navickis RJ, Wilkes MM (2004) Albumin versus crystalloid for pump priming in cardiac surgery: meta-analysis of controlled trials. J Cardiothorac Vasc Anesth 18:429–437

    Article  PubMed  CAS  Google Scholar 

  38. Myburgh J, Cooper DJ, Finfer S, Bellomo R, Norton R, Bishop N, Kai Lo S, Vallance S (2007) Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med 357:874–884

    Article  PubMed  CAS  Google Scholar 

  39. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K (2008) Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 358:125–139

    Article  PubMed  CAS  Google Scholar 

  40. Schortgen F, Lacherade JC, Bruneel F, Cattaneo I, Hemery F, Lemaire F, Brochard L (2001) Effects of hydroxyethylstarch and gelatin on renal function in severe sepsis: a multicentre randomised study. Lancet 357:911–916

    Article  PubMed  CAS  Google Scholar 

  41. Wiedermann CJ (2008) Systematic review of randomized clinical trials on the use of hydroxyethyl starch for fluid management in sepsis. BMC Emerg Med 8:1

    Article  PubMed  Google Scholar 

  42. Schabinski F, Oishi J, Tuche F, Luy A, Sakr Y, Bredle D, Hartog C, Reinhart K (2009) Effects of a predominantly hydroxyethyl starch (HES)-based and a predominantly non HES-based fluid therapy on renal function in surgical ICU patients. Intensive Care Med 35:1539–1547

    Article  PubMed  CAS  Google Scholar 

  43. Bayer O, Reinhart K, Sakr Y, Kabisch B, Kohl M, Riedemann NC, Bauer M, Settmacher U, Hekmat K, Hartog CS (2011) Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison. Crit Care Med 39:1335–1342

    Article  PubMed  CAS  Google Scholar 

  44. Wilkes MM, Navickis RJ, Sibbald WJ (2001) Albumin versus hydroxyethyl starch in cardiopulmonary bypass surgery: a meta-analysis of postoperative bleeding. Ann Thorac Surg 72:527–533

    Article  PubMed  CAS  Google Scholar 

  45. Moskowitz DM, Shander A, Javidroozi M, Klein JJ, Perelman SI, Nemeth J, Ergin MA (2008) Postoperative blood loss and transfusion associated with use of Hextend in cardiac surgery patients at a blood conservation center. Transfusion 48:768–775

    Article  PubMed  CAS  Google Scholar 

  46. Avorn J, Patel M, Levin R, Winkelmayer WC (2003) Hetastarch and bleeding complications after coronary artery surgery. Chest 124:1437–1442

    Article  PubMed  Google Scholar 

  47. Haynes GR, Havidich JE, Payne KJ (2004) Why the food and drug administration changed the warning label for hetastarch. Anesthesiology 101:560–561

    Article  PubMed  Google Scholar 

  48. Rioux JP, Lessard M, De Bortoli B, Roy P, Albert M, Verdant C, Madore F, Troyanov S (2009) Pentastarch 10% (250 kDa/0.45) is an independent risk factor of acute kidney injury following cardiac surgery. Crit Care Med 37:1293–1298

    Article  PubMed  CAS  Google Scholar 

  49. Magder S, Potter BJ, Varennes BD, Doucette S, Fergusson D (2010) Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids. Crit Care Med 38:2117–2124

    Article  PubMed  Google Scholar 

  50. Lissauer ME, Chi A, Kramer ME, Scalea TM, Johnson SB (2011) Association of 6% hetastarch resuscitation with adverse outcomes in critically ill trauma patients. Am J Surg 202(1):53–58

    Article  PubMed  CAS  Google Scholar 

  51. Tseng MY, Hutchinson PJ, Kirkpatrick PJ (2008) Effects of fluid therapy following aneurysmal subarachnoid haemorrhage: a prospective clinical study. Br J Neurosurg 22:257–268

    Article  PubMed  Google Scholar 

  52. Neff TA, Doelberg M, Jungheinrich C, Sauerland A, Spahn DR, Stocker R (2003) Repetitive large-dose infusion of the novel hydroxyethyl starch 130/0.4 in patients with severe head injury. Anesth Analg 96:1453–1459

    Article  PubMed  CAS  Google Scholar 

  53. Cittanova ML, Leblanc I, Legendre C, Mouquet C, Riou B, Coriat P (1996) Effect of hydroxyethylstarch in brain-dead kidney donors on renal function in kidney-transplant recipients. Lancet 348:1620–1622

    Article  PubMed  CAS  Google Scholar 

  54. Robert R, Guilhot J, Pinsard M, Longeard PL, Jacob JP, Gissot V, Hauet T, Seguin F (2011) A pair analysis of the delayed graft function in kidney recipient: the critical role of the donor. J Crit Care 25:582–590

    Google Scholar 

  55. Giral M, Bertola JP, Foucher Y, Villers D, Bironneau E, Blanloeil Y, Karam G, Daguin P, Lerat L, Soulillou JP (2007) Effect of brain-dead donor resuscitation on delayed graft function: results of a monocentric analysis. Transplantation 83:1174–1181

    Article  PubMed  Google Scholar 

  56. Hokema F, Ziganshyna S, Bartels M, Pietsch UC, Busch T, Jonas S, Kaisers U (2011) Is perioperative low molecular weight hydroxyethyl starch infusion a risk factor for delayed graft function in renal transplant recipients? Nephrol Dial Transplant 26(10):3373–3378

    Article  PubMed  CAS  Google Scholar 

  57. Deman A, Peeters P, Sennesael J (1999) Hydroxyethyl starch does not impair immediate renal function in kidney transplant recipients: a retrospective, multicentre analysis. Nephrol Dial Transplant 14:1517–1520

    Article  PubMed  CAS  Google Scholar 

  58. Wu Y, Wu AS, Wang J, Tian M, Jia XY, Rui Y, Yue Y (2010) Effects of the novel 6% hydroxyethyl starch 130/0.4 on renal function of recipients in living-related kidney transplantation. Chin Med J (Engl) 123:3079–3083

    CAS  Google Scholar 

  59. Jacob M, Chappell D, Conzen P, Wilkes MM, Becker BF, Rehm M (2008) Small-volume resuscitation with hyperoncotic albumin: a systematic review of randomized clinical trials. Crit Care 12:R34

    Article  PubMed  Google Scholar 

  60. Wiedermann CJ, Dunzendorfer S, Gaioni LU, Zaraca F, Joannidis M (2010) Hyperoncotic colloids and acute kidney injury: a meta-analysis of randomized trials. Crit Care 14:R191

    Article  PubMed  Google Scholar 

  61. Schortgen F, Girou E, Deye N, Brochard L (2008) The risk associated with hyperoncotic colloids in patients with shock. Intensive Care Med 34:2157–2168

    Article  PubMed  Google Scholar 

  62. Autrat-Leca E, Jonville-Béra A, Paintaud G (1999) Commission de Pharmacovigilance de l’AFFSaPS: Décisions: La durée maximale de traitement par Elohes. Actualités en Pharmacologie Clinique 47 http://membres.lycos.fr/crpv/Avril-Juil%2099.pdf. Accessed Jan 2006

  63. Thompson WL (1975) Rational use of albumin and plasma substitutes. Johns Hopkins Med J 136:220–225

    PubMed  CAS  Google Scholar 

  64. Bork K (2005) Pruritus precipitated by hydroxyethyl starch: a review. Br J Dermatol 152:3–12

    Article  PubMed  CAS  Google Scholar 

  65. Arellano R, Gan BS, Salpeter MJ, Yeo E, McCluskey S, Pinto R, Irish J, Ross DC, Doyle DJ, Parkin J, Brown D, Rotstein L, Witterick I, Matthews W, Yoo J, Neligan PC, Gullane P, Lampe H (2005) A triple-blinded randomized trial comparing the hemostatic effects of large-dose 10% hydroxyethyl starch 264/0.45 versus 5% albumin during major reconstructive surgery. Anesth Analg 100:1846–1853

    Article  PubMed  CAS  Google Scholar 

  66. Jamal R, Ghannoum M, Naud J, Turgeon P, Leblan M (2008) Permanent renal failure induced by pentastarch. NDT Plus 1(5):322–325

    Article  CAS  Google Scholar 

  67. Hagne C, Schwarz A, Gaspert A, Giambarba C, Keusch G (2009) HAES in septic shock—sword of Damocles? Schweiz Med Forum 9:304–306

    Google Scholar 

  68. Auwerda JJ, Leebeek FW, Wilson JH, van Diggelen OP, Lam KH, Sonneveld P (2006) Acquired lysosomal storage caused by frequent plasmapheresis procedures with hydroxyethyl starch. Transfusion 46:1705–1711

    Article  PubMed  CAS  Google Scholar 

  69. Ginz HF, Gottschall V, Schwarzkopf G, Walter K (1998) Excessive tissue storage of colloids in the reticuloendothelial system. Anaesthesist 47:330–334

    Article  PubMed  CAS  Google Scholar 

  70. Schmidt-Hieber M, Loddenkemper C, Schwartz S, Arntz G, Thiel E, Notter M (2006) Hydrops lysosomalis generalisatus: an underestimated side effect of hydroxyethyl starch therapy? Eur J Haematol 77:83–85

    Article  PubMed  Google Scholar 

  71. Boussekey N, Darmon R, Langlois J, Alfandari S, Devos P, Meybeck A, Chiche A, Georges H, Leroy O (2010) Resuscitation with low volume hydroxyethylstarch 130 kDa/0.4 is not associated with acute kidney injury. Crit Care 14:R40

    Article  PubMed  Google Scholar 

  72. Kasper SM, Meinert P, Kampe S, Gorg C, Geisen C, Mehlhorn U, Diefenbach C (2003) Large-dose hydroxyethyl starch 130/0.4 does not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with hydroxyethyl starch 200/0.5 at recommended doses. Anesthesiology 99:42–47

    Article  PubMed  CAS  Google Scholar 

  73. [No authors listed] (2007) US Department of Health and Human Services, Public health service, Food and Drug Administration (FDA). NDA REVIEW MEMO (MID-CYCLE). Available via http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/NewDrugApplicationsNDAs/UCM083393.pdf. Accessed 20 Nov 2010

  74. Westphal M, James MF, Kozek-Langenecker S, Stocker R, Guidet B, Van Aken H (2009) Hydroxyethyl starches: different products—different effects. Anesthesiology 111:187–202

    Article  PubMed  CAS  Google Scholar 

  75. Kozek-Langenecker SA, Jungheinrich C, Sauermann W, Van der Linden P (2008) The effects of hydroxyethyl starch 130/0.4 (6%) on blood loss and use of blood products in major surgery: a pooled analysis of randomized clinical trials. Anesth Analg 107:382–390

    Article  PubMed  CAS  Google Scholar 

  76. Blasco V, Leone M, Antonini F, Geissler A, Albanese J, Martin C (2008) Comparison of the novel hydroxyethylstarch 130/0.4 and hydroxyethylstarch 200/0.6 in brain-dead donor resuscitation on renal function after transplantation. Br J Anaesth 100:504–508

    Article  PubMed  CAS  Google Scholar 

  77. Gattas (2011) Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis. Anesth Analg (in press)

  78. James MF, Michell WL, Joubert IA, Nicol AJ, Navsaria PH, Gillespie RS (2011) Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma). Br J Anaesth 107:693–702

    Article  PubMed  CAS  Google Scholar 

  79. James MFM, Michell WL, Joubert IA, Nicol AJ, Navsaria PH, Gillespie RS (2012) Re:Hydroxy ethyl starch in patients with trauma. E-Letter. BJA. http://bja.oxfordjournals.org/content/early/2011/08/19/bja.aer229.long/reply#brjana_el_7842. Accessed 25 Jan 2012

  80. Nunnally ME, Jaeschke R, Bellingan GJ, Lacroix J, Mourvillier B, Rodriguez-Vega GM, Rubertsson S, Vassilakopoulos T, Weinert C, Zanotti-Cavazzoni S, Buchman TG (2011) Targeted temperature management in critical care: a report and recommendations from five professional societies. Crit Care Med 39:1113–1125

    Article  PubMed  Google Scholar 

  81. Velanovich V (1989) Crystalloid versus colloid fluid resuscitation: a meta-analysis of mortality. Surgery 105:65–71

    PubMed  CAS  Google Scholar 

  82. Bisonni RS, Holtgrave DR, Lawler F, Marley DS (1991) Colloids versus crystalloids in fluid resuscitation: an analysis of randomized controlled trials. J Fam Pract 32:387–390

    PubMed  CAS  Google Scholar 

  83. Schierhout G, Roberts I (1998) Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials. BMJ 316:961–964

    Article  PubMed  CAS  Google Scholar 

  84. Himpe D (2003) Colloids versus crystalloids as priming solutions for cardiopulmonary bypass: a meta-analysis of prospective, randomised clinical trials. Acta Anaesthesiol Belg 54:207–215

    PubMed  CAS  Google Scholar 

  85. Alderson P, Schierhout G, Roberts I, Bunn F (2000) Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev: CD000567

  86. Roberts I, Alderson P, Bunn F, Chinnock P, Ker K, Schierhout G (2004) Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev: CD000567

  87. Akech S, Ledermann H, Maitland K (2010) Choice of fluids for resuscitation in children with severe infection and shock: systematic review. BMJ 341:c4416

    Article  PubMed  Google Scholar 

  88. Choi PT, Yip G, Quinonez LG, Cook DJ (1999) Crystalloids vs. colloids in fluid resuscitation: a systematic review. Crit Care Med 27:200–210

    Article  PubMed  CAS  Google Scholar 

  89. Cyna AM, Andrew M, Emmett RS, Middleton P, Simmons SW (2009) Techniques for preventing hypotension during spinal anaesthesia for caesarean section. Cochrane Database Syst Rev: CD002251

  90. Bunn F, Trivedi D, Ashraf S (2008) Colloid solutions for fluid resuscitation. Cochrane Database Syst Rev: CD001319

  91. Liberati A, Moja L, Moschetti I, Gensini GF, Gusinu R (2006) Human albumin solution for resuscitation and volume expansion in critically ill patients. Intern Emerg Med 1:243–245

    Article  PubMed  Google Scholar 

  92. Bayer O, Reinhart K, Sakr Y, Kabisch B, Kohl M, Riedemann NC, Bauer M, Settmacher U, Hekmat K, Hartog CS (2011) Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison. Crit Care Med 39(6):1335–1342

    Article  Google Scholar 

  93. Gondos T, Marjanek Z, Ulakcsai Z, Szabo Z, Bogar L, Karolyi M, Gartner B, Kiss K, Havas A, Futo J (2010) Short-term effectiveness of different volume replacement therapies in postoperative hypovolaemic patients. Eur J Anaesthesiol 27:794–800

    Article  PubMed  Google Scholar 

  94. Hecht-Dolnik M, Barkan H, Taharka A, Loftus J (2009) Hetastarch increases the risk of bleeding complications in patients after off-pump coronary bypass surgery: a randomized clinical trial. J Thorac Cardiovasc Surg 138:703–711

    Article  PubMed  Google Scholar 

  95. van der Heijden M, Verheij J, van Nieuw Amerongen GP, Groeneveld AB (2009) Crystalloid or colloid fluid loading and pulmonary permeability, edema, and injury in septic and nonseptic critically ill patients with hypovolemia. Crit Care Med 37:1275–1281

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

Support was provided solely from institutional and/or departmental sources.

Conflicts of interest

C.L.S., R.J., F.S., A.B.J.G., R.B., and C.S.H. declare no conflict of interest. A.P. has received support for research from B. Braun Medical and Fresenius Kabi and honoraria from Ferring Pharmaceuticals. A.B.J.G. has received unrestricted research grants from B. Braun in the past. K.R. has received unrestricted research grant for the conduct of the VISEP trial and consultancy fees from B. Braun Melsungen.

Author information

Authors and Affiliations

  1. Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller University, Erlanger Allee 101, 07747, Jena, Germany

    Konrad Reinhart & Christiane S. Hartog

  2. Department of Intensive Care, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

    Anders Perner

  3. Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel

    Charles L. Sprung

  4. Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada

    Roman Jaeschke

  5. Réanimation Médicale, AP-HP, Groupe Hospitalier Albert Chenevier, Henri Mondor, Créteil, France

    Frederique Schortgen

  6. Erasmus Medical Centre, Rotterdam, The Netherlands

    A. B. Johan Groeneveld

  7. Department of Adult Critical Care, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

    Richard Beale

Authors
  1. Konrad Reinhart
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anders Perner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Charles L. Sprung
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roman Jaeschke
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Frederique Schortgen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. B. Johan Groeneveld
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Richard Beale
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Christiane S. Hartog
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Konrad Reinhart.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 104 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reinhart, K., Perner, A., Sprung, C.L. et al. Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. Intensive Care Med 38, 368–383 (2012). https://doi.org/10.1007/s00134-012-2472-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-012-2472-9

Keywords

Search

Navigation