Human metapneumovirus in bronchoalveolar lavage fluid of critically ill patients with suspected pneumonia
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Respiratory infections are a major cause of morbidity and mortality worldwide. Although the clinical features are easily recognized, the cause of a large proportion of respiratory infections, especially in immunocompromised patients, remains unknown. Bronchoalveolar lavage (BAL) cytological analysis and culture is routinely used in the assessment of various lung diseases. However, BAL fluid (BALF) analysis does not always result in identification of a causative organism. Since its discovery in 2001, human metapneumovirus (hMPV) has been shown to be the cause of respiratory tract disease worldwide . However, it is very difficult to culture and thus may have been missed as a causative agent in the past. Therefore we performed a study to investigate the presence of hMPV in critically ill patients suspected of hospital-acquired pneumonia (HAP).
The study was performed in the 18-bed general intensive care unit (ICU) of the Maastricht University Medical Centre in The...
KeywordsIntensive Care Unit Respiratory Failure Respiratory Syncytial Virus Bronchoalveolar Lavage Intensive Care Unit Admittance