Advertisement

Intensive Care Medicine

, Volume 38, Issue 4, pp 728–729 | Cite as

Human metapneumovirus in bronchoalveolar lavage fluid of critically ill patients with suspected pneumonia

  • Marijke J. Vanspauwen
  • Walther N. van Mook
  • Cathrien A. Bruggeman
  • Dennis C. J. J. Bergmans
  • Catharina F. M. LinssenEmail author
Correspondence

Dear Editor,

Respiratory infections are a major cause of morbidity and mortality worldwide. Although the clinical features are easily recognized, the cause of a large proportion of respiratory infections, especially in immunocompromised patients, remains unknown. Bronchoalveolar lavage (BAL) cytological analysis and culture is routinely used in the assessment of various lung diseases. However, BAL fluid (BALF) analysis does not always result in identification of a causative organism. Since its discovery in 2001, human metapneumovirus (hMPV) has been shown to be the cause of respiratory tract disease worldwide [1]. However, it is very difficult to culture and thus may have been missed as a causative agent in the past. Therefore we performed a study to investigate the presence of hMPV in critically ill patients suspected of hospital-acquired pneumonia (HAP).

The study was performed in the 18-bed general intensive care unit (ICU) of the Maastricht University Medical Centre in The...

Keywords

Intensive Care Unit Respiratory Failure Respiratory Syncytial Virus Bronchoalveolar Lavage Intensive Care Unit Admittance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Gray GC, Capuano AW, Setterquist SF, Erdman DD, Nobbs ND, Abed Y, Doern GV, Starks SE, Boivin G (2006) Multi-year study of human metapneumovirus infection at a large US midwestern medical referral center. J Clin Virol 37:269–276PubMedCrossRefGoogle Scholar
  2. 2.
    Morrow BM, Hatherill M, Smuts HE, Yeats J, Pitcher R, Argent AC (2006) Clinical course of hospitalised children infected with human metapneumovirus and respiratory syncytial virus. J Paediatr Child Health 42:174–178PubMedCrossRefGoogle Scholar
  3. 3.
    O’Gorman C, McHenry E, Coyle PV (2006) Human metapneumovirus in adults: a short case series. Eur J Clin Microbiol Infect Dis 25:190–192PubMedCrossRefGoogle Scholar
  4. 4.
    van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RAM, Osterhaus ADME (2001) A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 7:719–724PubMedCrossRefGoogle Scholar
  5. 5.
    Wilkesmann A, Schildgen O, Eis-Hubinger AM, Geikowski T, Glatzel T, Lentze MJ, Bode U, Simon A (2006) Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections. Eur J Pediatr 165:467–475PubMedCrossRefGoogle Scholar

Copyright information

© Copyright jointly held by Springer and ESICM 2012

Authors and Affiliations

  • Marijke J. Vanspauwen
    • 1
  • Walther N. van Mook
    • 2
    • 3
  • Cathrien A. Bruggeman
    • 1
  • Dennis C. J. J. Bergmans
    • 2
  • Catharina F. M. Linssen
    • 1
    Email author
  1. 1.Department of Medical Microbiology, School for Public Health and Primary CareMaastricht University Medical CentreMaastrichtThe Netherlands
  2. 2.Department of Intensive Care MedicineMaastricht University Medical CentreMaastrichtThe Netherlands
  3. 3.Department of Internal MedicineMaastricht University Medical CentreMaastrichtThe Netherlands

Personalised recommendations