Intensive Care Medicine

, 37:1809 | Cite as

Cerebral tissue oxygenation measured by two different probes: challenges and interpretation

  • Julius Dengler
  • Christin Frenzel
  • Peter Vajkoczy
  • Stefan Wolf
  • Peter Horn



Cerebral tissue oxygenation (PbrO2) is most frequently monitored using a Licox CC1.SB system (LX, Integra Neuroscience, France) but recently a new probe—the Neurovent-PTO (NV)—was introduced by a different manufacturer (Raumedic, Germany). There are no prospective data on how these probes compare in clinical routine. We therefore compared both probes in comatose patients suffering from traumatic brain injury (TBI) or subarachnoid haemorrhage (SAH) during dynamic changes of inspirational oxygen fraction (FiO2) and mean arterial pressure (MAP).


PbrO2 in 11 patients was recorded continuously using an LX and NV probe placed side by side into the same cerebrovascular region. Once a steady baseline value was reached FiO2 was increased by 20% for 10 min. Once the baseline values were re-established MAP was increased by 20 mmHg for 10 min. Evaluation was performed using a four-parameter logistic function and Bland–Altman analyses.


PbrO2 values of both probes differed significantly at all times. The LX probe reacted significantly faster to changes in FiO2 and MAP. Limits of agreement ranged between −32.1 and 20.0 mmHg. Mean LX values were 6.1 mmHg lower than NV values.


Since the examined patient cohort was rather small, this study’s results are preliminary. However, they suggest that LX and NV probes measure different PbrO2 values in routine monitoring as well as during phases of dynamic changes in FiO2 and MAP. These data therefore do not support the view that both probes can be used interchangeably.


Licox Raumedic Cerebral tissue oxygenation PbrO2 Cerebral autoregulation 



The study was exclusively funded by the Department of Neurosurgery of the Charité, Berlin.

Conflict of interest

The authors are not subject to any conflict of interest.


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Copyright information

© Copyright jointly held by Springer and ESICM 2011

Authors and Affiliations

  • Julius Dengler
    • 1
  • Christin Frenzel
    • 1
  • Peter Vajkoczy
    • 1
  • Stefan Wolf
    • 1
  • Peter Horn
    • 1
  1. 1.Department of Neurosurgery, CharitéUniversitaetsmedizin BerlinBerlinGermany

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