Intensive Care Medicine

, Volume 37, Issue 2, pp 272–283 | Cite as

Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection

  • I. Martin-Loeches
  • T. Lisboa
  • A. Rhodes
  • R. P. Moreno
  • E. Silva
  • C. Sprung
  • J. D. Chiche
  • D. Barahona
  • M. Villabon
  • C. Balasini
  • R. M. Pearse
  • R. Matos
  • J. RelloEmail author
  • The ESICM H1N1 Registry Contributors



Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial.


Prospective, observational, multicenter study from 23 June 2009 through 11 February 2010, reported in the European Society of Intensive Care Medicine (ESICM) H1N1 registry.


Two hundred twenty patients admitted to an intensive care unit (ICU) with completed outcome data were analyzed. Invasive mechanical ventilation was used in 155 (70.5%). Sixty-seven (30.5%) of the patients died in ICU and 75 (34.1%) whilst in hospital. One hundred twenty-six (57.3%) patients received corticosteroid therapy on admission to ICU. Patients who received corticosteroids were significantly older and were more likely to have coexisting asthma, chronic obstructive pulmonary disease (COPD), and chronic steroid use. These patients receiving corticosteroids had increased likelihood of developing hospital-acquired pneumonia (HAP) [26.2% versus 13.8%, p < 0.05; odds ratio (OR) 2.2, confidence interval (CI) 1.1–4.5]. Patients who received corticosteroids had significantly higher ICU mortality than patients who did not (46.0% versus 18.1%, p < 0.01; OR 3.8, CI 2.1–7.2). Cox regression analysis adjusted for severity and potential confounding factors identified that early use of corticosteroids was not significantly associated with mortality [hazard ratio (HR) 1.3, 95% CI 0.7–2.4, p = 0.4] but was still associated with an increased rate of HAP (OR 2.2, 95% CI 1.0–4.8, p < 0.05). When only patients developing acute respiratory distress syndrome (ARDS) were analyzed, similar results were observed.


Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection did not result in better outcomes and was associated with increased risk of superinfections.


Community acquired pneumonia Pandemic (H1N1)v influenza A infection Corticosteroid therapy ARDS 


Conflict of interest

Authors declare no conflict of interest regarding the present manuscript.


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Copyright information

© Copyright jointly held by Springer and ESICM 2010

Authors and Affiliations

  • I. Martin-Loeches
    • 1
  • T. Lisboa
    • 1
    • 2
  • A. Rhodes
    • 3
  • R. P. Moreno
    • 4
  • E. Silva
    • 5
  • C. Sprung
    • 6
  • J. D. Chiche
    • 7
  • D. Barahona
    • 8
  • M. Villabon
    • 9
  • C. Balasini
    • 10
  • R. M. Pearse
    • 11
  • R. Matos
    • 4
  • J. Rello
    • 12
    Email author
  • The ESICM H1N1 Registry Contributors
  1. 1.Critical Care DepartmentJoan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes)TarragonaSpain
  2. 2.Critical Care DepartmentHospital de Clinicas de Porto AlegrePorto AlegreBrazil
  3. 3.Critical Care Department, St. George’s Healthcare NHS TrustLondonUK
  4. 4.Unidade de Cuidados Intensivos PolivalenteHospital de St. António dos Capuchos, Centro Hospitalar de Lisboa Central, E.P.E.LisbonPortugal
  5. 5.ICU, Hospital Israelita Albert EinsteinSão PauloBrazil
  6. 6.Department of Anesthesiology and Critical Care MedicineHadassah Hebrew University Medical CenterJerusalemIsrael
  7. 7.Service de Réanimation Médicale, Hôpital Cochin (AP-HP)Université Paris DescartesPrisFrance
  8. 8.Unidad de Cuidados IntensivosHospital Eugenio EspejoQuitoEcuador
  9. 9.Unidad de Cuidados IntensivosHospital de San JoséBogotáColombia
  10. 10.Unidad de Cuidados IntensivosHospital San MartínLa PlataArgentina
  11. 11.Barts and The London School of Medicine and DentistryQueen Mary’s University of London Royal London HospitalLondonUK
  12. 12.Critical Care Department, Vall d’Hebron University Hospital, Institut de Recerca Vall D’HebronUniversity Autonoma Barcelona, CIBER Enfermedades Respiratorias (CIBERes)BarcelonaSpain

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