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Intensive Care Medicine

, Volume 36, Issue 11, pp 1899–1905 | Cite as

Extracorporeal membrane oxygenation for severe influenza A (H1N1) acute respiratory distress syndrome: a prospective observational comparative study

  • Antoine RochEmail author
  • Renaud Lepaul-Ercole
  • Dominique Grisoli
  • Jacques Bessereau
  • Olivier Brissy
  • Matthias Castanier
  • Stephanie Dizier
  • Jean-Marie Forel
  • Christophe Guervilly
  • Vlad Gariboldi
  • Frederic Collart
  • Pierre Michelet
  • Gilles Perrin
  • Remi Charrel
  • Laurent Papazian
Original

Abstract

Purpose

To compare characteristics, clinical evolution and outcome in adult patients with influenza A (H1N1) acute respiratory distress syndrome (ARDS) treated with or without extracorporeal membrane oxygenation (ECMO).

Methods

A prospective observational study of patients treated in Marseille South Hospital from October 2009 to January 2010 for confirmed influenza A (H1N1)-related ARDS. Clinical features, pulmonary dysfunction and mortality were compared between patients treated with and without ECMO.

Results

Of 18 patients admitted, 6 were treated with veno-venous and 3 with veno-arterial ECMO after median (interquartile, IQR) duration of mechanical ventilation of 10 (6–96) h. Six ECMO were initiated in a referral hospital by a mobile team, a median (IQR) of 3 (2–4) h after phone contact. Before ECMO, patients had severe respiratory failure with median (IQR) PaO2 to FiO2 ratio of 52 (50–60) mmHg and PaCO2 of 85 (69–91) mmHg. Patients treated with or without ECMO had the same hospital mortality rate (56%, 5/9). Duration of ECMO therapy was 9 (4–14) days in survivors and 5 (2–25) days in non-survivors. Early improvement of PaO2 to FiO2 ratio was greater in ECMO survivors than non-survivors after ECMO initiation [295 (151–439) versus 131 (106–144) mmHg, p < 0.05]. Haemorrhagic complications occurred in four patients under ECMO, but none required surgical treatment.

Conclusions

ECMO may be an effective salvage treatment for patients with influenza A (H1N1)-related ARDS presenting rapid refractory respiratory failure, particularly when provided by a mobile team allowing early cannulation prior to transfer to a reference centre.

Keywords

Acute respiratory distress syndrome (ARDS) Extracorporeal membrane oxygenation Influenza A (H1N1) Pneumonia 

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Copyright information

© Copyright jointly held by Springer and ESICM 2010

Authors and Affiliations

  • Antoine Roch
    • 1
    Email author
  • Renaud Lepaul-Ercole
    • 1
  • Dominique Grisoli
    • 2
  • Jacques Bessereau
    • 3
  • Olivier Brissy
    • 1
  • Matthias Castanier
    • 1
  • Stephanie Dizier
    • 1
  • Jean-Marie Forel
    • 1
  • Christophe Guervilly
    • 1
  • Vlad Gariboldi
    • 2
  • Frederic Collart
    • 2
  • Pierre Michelet
    • 3
  • Gilles Perrin
    • 1
  • Remi Charrel
    • 4
  • Laurent Papazian
    • 1
  1. 1.Service de Réanimation, Hôpital Sainte MargueriteMarseille Cedex 9France
  2. 2.Service de Chirurgie Cardiaque, Hôpital de la TimoneMarseilleFrance
  3. 3.Service d’Aide Médicale Urgente (SAMU), Hôpital de la TimoneMarseilleFrance
  4. 4.Laboratoire de Virologie, Hôpital de la TimoneMarseilleFrance

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