Intensive Care Medicine

, Volume 36, Issue 8, pp 1333–1340

Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury

  • Johan Mårtensson
  • Max Bell
  • Anders Oldner
  • Shengyuan Xu
  • Per Venge
  • Claes-Roland Martling
Original

DOI: 10.1007/s00134-010-1887-4

Cite this article as:
Mårtensson, J., Bell, M., Oldner, A. et al. Intensive Care Med (2010) 36: 1333. doi:10.1007/s00134-010-1887-4

Abstract

Purpose

To study the impact of inflammation/sepsis on the concentrations of neutrophil gelatinase-associated lipocalin (NGAL) in plasma and urine in adult intensive care unit (ICU) patients and to estimate the predictive properties of NGAL in plasma and urine for early detection of acute kidney injury (AKI) in patients with septic shock.

Methods

Sixty-five patients admitted to the general ICU at the Karolinska University Hospital Solna, Sweden, with normal plasma creatinine were assessed for eligibility. Twenty-seven patients with systemic inflammatory response syndrome (SIRS), severe sepsis, or septic shock without AKI and 18 patients with septic shock and concomitant AKI were included in the final analysis. Plasma and urine were analyzed twice daily for plasma NGAL (pNGAL), C-reactive protein (CRP), procalcitonin, myeloperoxidase, plasma cystatin C, plasma creatinine, urine NGAL (uNGAL), urine cystatin C, and urine α1-microglobulin.

Results

Of the 45 patients, 40 had elevated peak levels of pNGAL. Peak levels of pNGAL were not significantly different between septic shock patients with and without AKI. Peak levels of uNGAL were below the upper reference limit in all but four patients without AKI. uNGAL was a good predictor (area under ROC 0.86) whereas pNGAL was a poor predictor (area under ROC 0.67) for AKI within the next 12 h in patients with septic shock.

Conclusions

pNGAL is raised in patients with SIRS, severe sepsis, and septic shock and should be used with caution as a marker of AKI in ICU patients with septic shock. uNGAL is more useful in predicting AKI as the levels are not elevated in septic patients without AKI.

Keywords

AKI Cystatin C HNL NGAL RIFLE Sepsis 

Supplementary material

134_2010_1887_MOESM1_ESM.doc (36 kb)
Supplementary material 1 (DOC 36 kb)

Copyright information

© Copyright jointly held by Springer and ESICM 2010

Authors and Affiliations

  • Johan Mårtensson
    • 1
  • Max Bell
    • 1
  • Anders Oldner
    • 1
  • Shengyuan Xu
    • 2
  • Per Venge
    • 2
  • Claes-Roland Martling
    • 1
  1. 1.Department of Physiology and PharmacologyKarolinska InstitutetStockholmSweden
  2. 2.Department of Medical Sciences, Clinical ChemistryUppsala UniversityUppsalaSweden

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