Intensive Care Medicine

, Volume 36, Issue 3, pp 392–411 | Cite as

Prevention of acute kidney injury and protection of renal function in the intensive care unit

Expert opinion of the working group for nephrology, ESICM
  • Michael Joannidis
  • Wilfred Druml
  • Lui G. Forni
  • A. B. Johan Groeneveld
  • Patrick Honore
  • Heleen M. Oudemans-van Straaten
  • Claudio Ronco
  • Marie R. C. Schetz
  • Arend Jan Woittiez
Expert Panel

Abstract

Background

Acute renal failure on the intensive care unit is associated with significant mortality and morbidity.

Objectives

To determine recommendations for the prevention of acute kidney injury (AKI), focusing on the role of potential preventative maneuvers including volume expansion, diuretics, use of inotropes, vasopressors/vasodilators, hormonal interventions, nutrition, and extracorporeal techniques.

Method

A systematic search of the literature was performed for studies using these potential protective agents in adult patients at risk for acute renal failure/kidney injury between 1966 and 2009. The following clinical conditions were considered: major surgery, critical illness, sepsis, shock, and use of potentially nephrotoxic drugs and radiocontrast media. Where possible the following endpoints were extracted: creatinine clearance, glomerular filtration rate, increase in serum creatinine, urine output, and markers of tubular injury. Clinical endpoints included the need for renal replacement therapy, length of stay, and mortality. Studies are graded according to the international Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) group system

Conclusions and recommendations

Several measures are recommended, though none carries grade 1A. We recommend prompt resuscitation of the circulation with special attention to providing adequate hydration whilst avoiding high-molecular-weight hydroxy-ethyl starch (HES) preparations, maintaining adequate blood pressure using vasopressors in vasodilatory shock. We suggest using vasopressors in vasodilatory hypotension, specific vasodilators under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.

Keywords

Acute kidney injury Systematic review Recommendations Position paper Prevention Volume expansion Vasopressors Vasodilators Diuretics Hormones APC Renal replacement therapy 

Supplementary material

134_2009_1678_MOESM1_ESM.doc (168 kb)
(DOC 168 kb)

References

  1. 1.
    Chertow GM, Levy EM, Hammermeister KE, Grover F, Daley J (1998) Independent association between acute renal failure and mortality following cardiac surgery. Am J Med 104:343–348PubMedCrossRefGoogle Scholar
  2. 2.
    Groeneveld AB, Tran DD, van der MJ, Nauta JJ, Thijs LG (1991) Acute renal failure in the medical intensive care unit: predisposing, complicating factors and outcome. Nephron 59:602–610Google Scholar
  3. 3.
    Levy EM, Viscoli CM, Horwitz RI (1996) The effect of acute renal failure on mortality. A cohort analysis. JAMA 275:1489–1494PubMedCrossRefGoogle Scholar
  4. 4.
    Metnitz PG, Krenn CG, Steltzer H, Lang T, Ploder J, Lenz K, Le G Jr, Druml W (2002) Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Crit Care Med 30:2051–2058PubMedCrossRefGoogle Scholar
  5. 5.
    Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A (2007) Acute Kidney Injury Network (AKIN): report of an initiative to improve outcomes in acute kidney injury. Crit Care 11:R31PubMedCrossRefGoogle Scholar
  6. 6.
    Weisbord SD, Mor MK, Resnick AL, Hartwig KC, Sonel AF, Fine MJ, Palevsky PM (2008) Prevention, incidence, and outcomes of contrast-induced acute kidney injury. Arch Intern Med 168:1325–1332PubMedCrossRefGoogle Scholar
  7. 7.
    Joannidis M, Metnitz PG (2005) Epidemiology and natural history of acute renal failure in the ICU. Crit Care Clin 21:239–249PubMedCrossRefGoogle Scholar
  8. 8.
    Ricci Z, Cruz D, Ronco C (2008) The RIFLE criteria and mortality in acute kidney injury: a systematic review. Kidney Int 73:538–546PubMedCrossRefGoogle Scholar
  9. 9.
    Morgera S, Schneider M, Neumayer HH (2008) Long-term outcomes after acute kidney injury. Crit Care Med 36:S193–S197PubMedCrossRefGoogle Scholar
  10. 10.
    Cruz DN, Ronco C (2007) Acute kidney injury in the intensive care unit: current trends in incidence and outcome. Crit Care 11:149PubMedCrossRefGoogle Scholar
  11. 11.
    Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De BD, Kellum JA (2006) RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 10:R73PubMedCrossRefGoogle Scholar
  12. 12.
    Joannidis M (2004) Drug-induced renal failure in the ICU. Int J Artif Organs 27:1034–1042PubMedGoogle Scholar
  13. 13.
    Kellum JA (2008) Acute kidney injury. Crit Care Med 36:S141–S145PubMedCrossRefGoogle Scholar
  14. 14.
    Lameire N, Van BW, Vanholder R (2008) Acute kidney injury. Lancet 372:1863–1865PubMedCrossRefGoogle Scholar
  15. 15.
    Bagshaw SM, George C, Gibney RT, Bellomo R (2008) A multi-center evaluation of early acute kidney injury in critically ill trauma patients. Ren Fail 30:581–589PubMedCrossRefGoogle Scholar
  16. 16.
    Cruz DN, Bolgan I, Perazella MA, Bonello M, de CM, Corradi V, Polanco N, Ocampo C, Nalesso F, Piccinni P, Ronco C (2007) North East Italian Prospective Hospital Renal Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI): targeting the problem with the RIFLE Criteria. Clin J Am Soc Nephrol 2:418–425Google Scholar
  17. 17.
    Prescott GJ, Metcalfe W, Baharani J, Khan IH, Simpson K, Smith WC, MacLeod AM (2007) A prospective national study of acute renal failure treated with RRT: incidence, aetiology and outcomes. Nephrol Dial Transplant 22:2513–2519PubMedCrossRefGoogle Scholar
  18. 18.
    Thakar CV, Arrigain S, Worley S, Yared JP, Paganini EP (2005) A clinical score to predict acute renal failure after cardiac surgery. J Am Soc Nephrol 16:162–168PubMedCrossRefGoogle Scholar
  19. 19.
    Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz GS, Lansky AJ, Moses JW, Stone GW, Leon MB, Dangas G (2004) A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol 44:1393–1399PubMedGoogle Scholar
  20. 20.
    Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL (2008) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 34:17–60PubMedCrossRefGoogle Scholar
  21. 21.
    Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, Hill S, Jaeschke R, Leng G, Liberati A, Magrini N, Mason J, Middleton P, Mrukowicz J, O’Connell D, Oxman AD, Phillips B, Schunemann HJ, Edejer TT, Varonen H, Vist GE, Williams JW Jr., Zaza S (2004) Grading quality of evidence and strength of recommendations. BMJ 19;328:1490Google Scholar
  22. 22.
    Guyatt G, Gutterman D, Baumann MH, Addrizzo-Harris D, Hylek EM, Phillips B, Raskob G, Lewis SZ, Schunemann H (2006) Grading strength of recommendations and quality of evidence in clinical guidelines: report from an American college of chest physicians task force. Chest 129:174–181PubMedCrossRefGoogle Scholar
  23. 23.
    De Mendonca A, Vincent JL, Suter PM, Moreno R, Dearden NM, Antonelli M, Takala J, Sprung C, Cantraine F (2000) Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score. Intensive Care Med 26:915–921PubMedCrossRefGoogle Scholar
  24. 24.
    Guerin C, Girard R, Selli JM, Perdrix JP, Ayzac L (2000) Initial versus delayed acute renal failure in the intensive care unit. A multicenter prospective epidemiological study. Rhone-Alpes Area Study Group on Acute Renal Failure. Am J Respir Crit Care Med 161:872–879PubMedGoogle Scholar
  25. 25.
    Schwilk B, Wiedeck H, Stein B, Reinelt H, Treiber H, Bothner U (1997) Epidemiology of acute renal failure and outcome of haemodiafiltration in intensive care. Intensive Care Med 23:1204–1211PubMedCrossRefGoogle Scholar
  26. 26.
    Himmelfarb J, Joannidis M, Molitoris B, Schietz M, Okusa MD, Warnock D, Laghi F, Goldstein SL, Prielipp R, Parikh CR, Pannu N, Lobo SM, Shah S, D’Intini V, Kellum JA (2008) Evaluation and initial management of acute kidney injury. Clin J Am Soc Nephrol 3:962–967PubMedCrossRefGoogle Scholar
  27. 27.
    Badr KF, Ichikawa I (1988) Prerenal failure: a deleterious shift from renal compensation to decompensation. N Engl J Med 319:623–629PubMedGoogle Scholar
  28. 28.
    Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, de Boisblanc B, Connors AF Jr, Hite RD, Harabin AL (2006) Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 354:2564–2575PubMedCrossRefGoogle Scholar
  29. 29.
    Malbrain ML, Chiumello D, Pelosi P, Wilmer A, Brienza N, Malcangi V, Bihari D, Innes R, Cohen J, Singer P, Japiassu A, Kurtop E, De Keulenaer BL, Daelemans R, Del TM, Cosimini P, Ranieri M, Jacquet L, Laterre PF, Gattinoni L (2004) Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study. Intensive Care Med 30:822–829PubMedCrossRefGoogle Scholar
  30. 30.
    Wilkes NJ, Woolf R, Mutch M, Mallett SV, Peachey T, Stephens R, Mythen MG (2001) The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid–base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth Analg 93:811–816PubMedCrossRefGoogle Scholar
  31. 31.
    Horgan KJ, Ottaviano YL, Watson AJ (1989) Acute renal failure due to mannitol intoxication. Am J Nephrol 9:106–109PubMedCrossRefGoogle Scholar
  32. 32.
    Rozich JD, Paul RV (1989) Acute renal failure precipitated by elevated colloid osmotic pressure. Am J Med 87:359–360PubMedCrossRefGoogle Scholar
  33. 33.
    Ahsan N, Palmer BF, Wheeler D, Greenlee RG Jr, Toto RD (1994) Intravenous immunoglobulin-induced osmotic nephrosis. Arch Intern Med 154:1985–1987PubMedCrossRefGoogle Scholar
  34. 34.
    Coronel B, Mercatello A, Martin X, Lefrancois N (1997) Hydroxyethylstarch and renal function in kidney transplant recipients. Lancet 349:884PubMedCrossRefGoogle Scholar
  35. 35.
    Legendre C, Thervet E, Page B, Percheron A, Noel LH, Kreis H (1993) Hydroxyethylstarch and osmotic-nephrosis-like lesions in kidney transplantation. Lancet 342:248–249PubMedCrossRefGoogle Scholar
  36. 36.
    Horstick G, Lauterbach M, Kempf T, Bhakdi S, Heimann A, Horstick M, Meyer J, Kempski O (2002) Early albumin infusion improves global and local hemodynamics and reduces inflammatory response in hemorrhagic shock. Crit Care Med 30:851–855PubMedCrossRefGoogle Scholar
  37. 37.
    Inoue M, Okajima K, Itoh K, Ando Y, Watanabe N, Yasaka T, Nagase S, Morino Y (1987) Mechanism of furosemide resistance in analbuminemic rats and hypoalbuminemic patients. Kidney Int 32:198–203PubMedCrossRefGoogle Scholar
  38. 38.
    Zhang H, Voglis S, Kim CH, Slutsky AS (2003) Effects of albumin and Ringer’s lactate on production of lung cytokines and hydrogen peroxide after resuscitated hemorrhage and endotoxemia in rats. Crit Care Med 31:1515–1522PubMedCrossRefGoogle Scholar
  39. 39.
    Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R (2004) A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 350:2247–2256PubMedCrossRefGoogle Scholar
  40. 40.
    Beyer R, Harmening U, Rittmeyer O, Zielmann S, Mielck F, Kazmaier S, Kettler D (1997) Use of modified fluid gelatin and hydroxyethyl starch for colloidal volume replacement in major orthopaedic surgery. Br J Anaesth 78:44–50PubMedGoogle Scholar
  41. 41.
    Schortgen F, Lacherade JC, Bruneel F, Cattaneo I, Hemery F, Lemaire F, Brochard L (2001) Effects of hydroxyethylstarch and gelatin on renal function in severe sepsis: a multicentre randomised study. Lancet 357:911–916PubMedCrossRefGoogle Scholar
  42. 42.
    Mardel SN, Saunders FM, Allen H, Menezes G, Edwards CM, Ollerenshaw L, Baddeley D, Kennedy A, Ibbotson RM (1998) Reduced quality of clot formation with gelatin-based plasma substitutes. Br J Anaesth 80:204–207PubMedGoogle Scholar
  43. 43.
    Tabuchi N, de HJ, Gallandat Huet RC, Boonstra PW, van OW (1995) Gelatin use impairs platelet adhesion during cardiac surgery. Thromb Haemost 74:1447–1451Google Scholar
  44. 44.
    Kurnik BR, Singer F, Groh WC (1991) Case report: dextran-induced acute anuric renal failure. Am J Med Sci 302:28–30PubMedGoogle Scholar
  45. 45.
    Laxenaire MC, Charpentier C, Feldman L (1994) Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms. A French multicenter prospective study. Ann Fr Anesth Reanim 13:301–310PubMedGoogle Scholar
  46. 46.
    Mailloux L, Swartz CD, Capizzi R, Kim KE, Onesti G, Ramirez O, Brest AN (1967) Acute renal failure after administration of low-molecular weight dextran. N Engl J Med 277:1113–1118PubMedCrossRefGoogle Scholar
  47. 47.
    Messmer KF (1987) The use of plasma substitutes with special attention to their side effects. World J Surg 11:69–74PubMedCrossRefGoogle Scholar
  48. 48.
    Bernard C, Alain M, Simone C, Xavier M, Jean-Francois M (1996) Hydroxyethylstarch and osmotic nephrosis-like lesions in kidney transplants. Lancet 348:1595PubMedCrossRefGoogle Scholar
  49. 49.
    Bork K (2005) Pruritus precipitated by hydroxyethyl starch: a review. Br J Dermatol 152:3–12PubMedCrossRefGoogle Scholar
  50. 50.
    Barron ME, Wilkes MM, Navickis RJ (2004) A systematic review of the comparative safety of colloids. Arch Surg 139:552–563PubMedCrossRefGoogle Scholar
  51. 51.
    Wiedermann CJ (2004) Hydroxyethyl starch—can the safety problems be ignored? Wien Klin Wochenschr 116:583–594PubMedCrossRefGoogle Scholar
  52. 52.
    Blasco V, Leone M, Antonini F, Geissler A, Albanese J, Martin C (2008) Comparison of the novel hydroxyethylstarch 130/0.4 and hydroxyethylstarch 200/0.6 in brain-dead donor resuscitation on renal function after transplantation. Br J Anaesth 100:504–508PubMedCrossRefGoogle Scholar
  53. 53.
    Boldt J, Suttner S, Brosch C, Lehmann A, Rohm K, Mengistu A (2009) The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients. Intensive Care Med 35:462–470PubMedCrossRefGoogle Scholar
  54. 54.
    Leuschner J, Opitz J, Winkler A, Scharpf R, Bepperling F (2003) Tissue storage of 14C-labelled hydroxyethyl starch (HES) 130/0.4 and HES 200/0.5 after repeated intravenous administration to rats. Drugs R D 4:331–338PubMedCrossRefGoogle Scholar
  55. 55.
    Schortgen F, Girou E, Deye N, Brochard L (2008) The risk associated with hyperoncotic colloids in patients with shock. Intensive Care Med 34:2157–2168PubMedCrossRefGoogle Scholar
  56. 56.
    Godet G, Lehot JJ, Janvier G, Steib A, De Castro, V, Coriat P (2008) Safety of HES 130/0.4 (Voluven(R)) in patients with preoperative renal dysfunction undergoing abdominal aortic surgery: a prospective, randomized, controlled, parallel-group multicentre trial. Eur J Anaesthesiol 20:1–9Google Scholar
  57. 57.
    Boldt J, Brosch C, Ducke M, Papsdorf M, Lehmann A (2007) Influence of volume therapy with a modern hydroxyethylstarch preparation on kidney function in cardiac surgery patients with compromised renal function: a comparison with human albumin. Crit Care Med 35:2740–2746PubMedCrossRefGoogle Scholar
  58. 58.
    Sedrakyan A, Gondek K, Paltiel D, Elefteriades JA (2003) Volume expansion with albumin decreases mortality after coronary artery bypass graft surgery. Chest 123:1853–1857PubMedCrossRefGoogle Scholar
  59. 59.
    Boldt J, Lehmann A, Rompert R, Haisch G, Isgro F (2000) Volume therapy with a new hydroxyethyl starch solution in cardiac surgical patients before cardiopulmonary bypass. J Cardiothorac Vasc Anesth 14:264–268PubMedCrossRefGoogle Scholar
  60. 60.
    Boldt J, Brosch C, Rohm K, Lehmann A, Mengistu A, Suttner S (2008) Is albumin administration in hypoalbuminemic elderly cardiac surgery patients of benefit with regard to inflammation, endothelial activation, and long-term kidney function? Anesth Analg 107:1496–1503PubMedCrossRefGoogle Scholar
  61. 61.
    Boldt J, Brosch C, Rohm K, Papsdorf M, Mengistu A (2008) Comparison of the effects of gelatin and a modern hydroxyethyl starch solution on renal function and inflammatory response in elderly cardiac surgery patients. Br J Anaesth 100:457–464PubMedCrossRefGoogle Scholar
  62. 62.
    Dehne MG, Muhling J, Sablotzki A, Dehne K, Sucke N, Hempelmann G (2001) Hydroxyethyl starch (HES) does not directly affect renal function in patients with no prior renal impairment. J Clin Anesth 13:103–111PubMedCrossRefGoogle Scholar
  63. 63.
    Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377PubMedCrossRefGoogle Scholar
  64. 64.
    Stockwell MA, Scott A, Day A, Riley B, Soni N (1992) Colloid solutions in the critically ill. A randomised comparison of albumin and polygeline 2. Serum albumin concentration and incidences of pulmonary oedema and acute renal failure. Anaesthesia 47:7–9PubMedCrossRefGoogle Scholar
  65. 65.
    Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K (2008) Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 358:125–139PubMedCrossRefGoogle Scholar
  66. 66.
    Sakr Y, Payen D, Reinhart K, Sipmann FS, Zavala E, Bewley J, Marx G, Vincent JL (2007) Effects of hydroxyethyl starch administration on renal function in critically ill patients. Br J Anaesth 98:216–224PubMedCrossRefGoogle Scholar
  67. 67.
    Solomon R, Werner C, Mann D, D’Elia J, Silva P (1994) Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents. N Engl J Med 331:1416–1420PubMedCrossRefGoogle Scholar
  68. 68.
    Mueller C, Buerkle G, Buettner HJ, Petersen J, Perruchoud AP, Eriksson U, Marsch S, Roskamm H (2002) Prevention of contrast media-associated nephropathy: randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty. Arch Intern Med 162:329–336PubMedCrossRefGoogle Scholar
  69. 69.
    Merten GJ, Burgess WP, Gray LV, Holleman JH, Roush TS, Kowalchuk GJ, Bersin RM, Van MA, Simonton CA III, Rittase RA, Norton HJ, Kennedy TP (2004) Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. JAMA 291:2328–2334PubMedCrossRefGoogle Scholar
  70. 70.
    Ozcan EE, Guneri S, Akdeniz B, Akyildiz IZ, Senaslan O, Baris N, Aslan O, Badak O (2007) Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. Am Heart J 154:539–544PubMedCrossRefGoogle Scholar
  71. 71.
    Masuda M, Yamada T, Mine T, Morita T, Tamaki S, Tsukamoto Y, Okuda K, Iwasaki Y, Hori M, Fukunami M (2007) Comparison of usefulness of sodium bicarbonate versus sodium chloride to prevent contrast-induced nephropathy in patients undergoing an emergent coronary procedure. Am J Cardiol 100:781–786PubMedCrossRefGoogle Scholar
  72. 72.
    Briguori C, Airoldi F, D’Andrea D, Bonizzoni E, Morici N, Focaccio A, Michev I, Montorfano M, Carlino M, Cosgrave J, Ricciardelli B, Colombo A (2007) Renal Insufficiency Following Contrast Media Administration Trial (REMEDIAL): a randomized comparison of 3 preventive strategies. Circulation 115:1211–1217PubMedGoogle Scholar
  73. 73.
    Recio-Mayoral A, Chaparro M, Prado B, Cozar R, Mendez I, Banerjee D, Kaski JC, Cubero J, Cruz JM (2007) The reno-protective effect of hydration with sodium bicarbonate plus N-acetylcysteine in patients undergoing emergency percutaneous coronary intervention: the RENO Study. J Am Coll Cardiol 49:1283–1288PubMedCrossRefGoogle Scholar
  74. 74.
    Hogan SE, L’Allier P, Chetcuti S, Grossman PM, Nallamothu BK, Duvernoy C, Bates E, Moscucci M, Gurm HS (2008) Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis. Am Heart J 156:414–421PubMedCrossRefGoogle Scholar
  75. 75.
    Pakfetrat M, Nikoo MH, Malekmakan L, Tabandeh M, Roozbeh J, Nasab MH, Ostovan MA, Salari S, Kafi M, Vaziri NM, Adl F, Hosseini M, Khajehdehi P (2009) A comparison of sodium bicarbonate infusion versus normal saline infusion and its combination with oral acetazolamide for prevention of contrast-induced nephropathy: a randomized, double-blind trial. Int Urol Nephrol 41:629–634PubMedCrossRefGoogle Scholar
  76. 76.
    Brar SS, Shen AY, Jorgensen MB, Kotlewski A, Aharonian VJ, Desai N, Ree M, Shah AI, Burchette RJ (2008) Sodium bicarbonate vs sodium chloride for the prevention of contrast medium-induced nephropathy in patients undergoing coronary angiography: a randomized trial. JAMA 300:1038–1046PubMedCrossRefGoogle Scholar
  77. 77.
    Maioli M, Toso A, Leoncini M, Gallopin M, Tedeschi D, Micheletti C, Bellandi F (2008) Sodium bicarbonate versus saline for the prevention of contrast-induced nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. J Am Coll Cardiol 52:599–604PubMedCrossRefGoogle Scholar
  78. 78.
    Adolph E, Holdt-Lehmann B, Chatterjee T, Paschka S, Prott A, Schneider H, Koerber T, Ince H, Steiner M, Schuff-Werner P, Nienaber CA (2008) Renal Insufficiency Following Radiocontrast Exposure Trial (REINFORCE): a randomized comparison of sodium bicarbonate versus sodium chloride hydration for the prevention of contrast-induced nephropathy. Coron Artery Dis 19:413–419PubMedGoogle Scholar
  79. 79.
    Joannidis M, Schmid M, Wiedermann CJ (2008) Prevention of contrast media-induced nephropathy by isotonic sodium bicarbonate: a meta-analysis. Wien Klin Wochenschr 120:742–748PubMedCrossRefGoogle Scholar
  80. 80.
    Navaneethan SD, Singh S, Appasamy S, Wing RE, Sehgal AR (2009) Sodium bicarbonate therapy for prevention of contrast-induced nephropathy: a systematic review and meta-analysis. Am J Kidney Dis 53:617–627PubMedCrossRefGoogle Scholar
  81. 81.
    Kanbay M, Covic A, Coca SG, Turgut F, Akcay A, Parikh CR (2009) Sodium bicarbonate for the prevention of contrast-induced nephropathy: a meta-analysis of 17 randomized trials. Int Urol Nephrol 41:617–627PubMedCrossRefGoogle Scholar
  82. 82.
    Haase M, Haase-Fielitz A, Bellomo R, Devarajan P, Story D, Matalanis G, Reade MC, Bagshaw SM, Seevanayagam N, Seevanayagam S, Doolan L, Buxton B, Dragun D (2009) Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial. Crit Care Med 37:39–47PubMedCrossRefGoogle Scholar
  83. 83.
    Branch RA (1988) Prevention of amphotericin B-induced renal impairment. A review on the use of sodium supplementation. Arch Intern Med 148:2389–2394PubMedCrossRefGoogle Scholar
  84. 84.
    Cheung TW, Jayaweera DT, Pearce D, Benson P, Nahass R, Olson C, Wool GM (2000) Safety of oral versus intravenous hydration during induction therapy with intravenous foscarnet in AIDS patients with cytomegalovirus infections. Int J STD AIDS 11:640–647PubMedCrossRefGoogle Scholar
  85. 85.
    Safrin S, Cherrington J, Jaffe HS (1999) Cidofovir. Review of current and potential clinical uses. Adv Exp Med Biol 458:111-20: 111-120Google Scholar
  86. 86.
    Perazella MA (1999) Crystal-induced acute renal failure. Am J Med 106:459–465PubMedCrossRefGoogle Scholar
  87. 87.
    Bagshaw SM, Delaney A, Jones D, Ronco C, Bellomo R (2007) Diuretics in the management of acute kidney injury: a multinational survey. Contrib Nephrol 156:236–49: 236–249Google Scholar
  88. 88.
    Bayati A, Nygren K, Kallskog O, Wolgast M (1990) The effect of loop diuretics on the long-term outcome of post-ischaemic acute renal failure in the rat. Acta Physiol Scand 139:271–279PubMedCrossRefGoogle Scholar
  89. 89.
    Heyman SN, Rosen S, Epstein FH, Spokes K, Brezis ML (1994) Loop diuretics reduce hypoxic damage to proximal tubules of the isolated perfused rat kidney. Kidney Int 45:981–985PubMedCrossRefGoogle Scholar
  90. 90.
    Kramer HJ, Schuurmann J, Wassermann C, Dusing R (1980) Prostaglandin-independent protection by furosemide from oliguric ischemic renal failure in conscious rats. Kidney Int 17:455–464PubMedCrossRefGoogle Scholar
  91. 91.
    Stevens MA, McCullough PA, Tobin KJ, Speck JP, Westveer DC, Guido-Allen DA, Timmis GC, O’Neill WW (1999) A prospective randomized trial of prevention measures in patients at high risk for contrast nephropathy: results of the P.R.I.N.C.E. Study. Prevention of Radiocontrast Induced Nephropathy Clinical Evaluation. J Am Coll Cardiol 33:403–411PubMedCrossRefGoogle Scholar
  92. 92.
    Weinstein JM, Heyman S, Brezis M (1992) Potential deleterious effect of furosemide in radiocontrast nephropathy. Nephron 62:413–415PubMedCrossRefGoogle Scholar
  93. 93.
    Brown CB, Ogg CS, Cameron JS (1981) High dose frusemide in acute renal failure: a controlled trial. Clin Nephrol 15:90–96PubMedGoogle Scholar
  94. 94.
    Lassnigg A, Donner E, Grubhofer G, Presterl E, Druml W, Hiesmayr M (2000) Lack of renoprotective effects of dopamine and furosemide during cardiac surgery. J Am Soc Nephrol 11:97–104PubMedGoogle Scholar
  95. 95.
    Cotter G, Weissgarten J, Metzkor E, Moshkovitz Y, Litinski I, Tavori U, Perry C, Zaidenstein R, Golik A (1997) Increased toxicity of high-dose furosemide versus low-dose dopamine in the treatment of refractory congestive heart failure. Clin Pharmacol Ther 62:187–193PubMedCrossRefGoogle Scholar
  96. 96.
    Hager B, Betschart M, Krapf R (1996) Effect of postoperative intravenous loop diuretic on renal function after major surgery. Schweiz Med Wochenschr 126:666–673Google Scholar
  97. 97.
    van der Voort PHJ, Boerma EC, Koopmans M, Zandberg M, de RJ, Gerritsen RT, Egbers PH, Kingma WP, Kuiper MA (2009) Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial. Crit Care Med 37:533–538Google Scholar
  98. 98.
    Shilliday IR, Quinn KJ, Allison ME (1997) Loop diuretics in the management of acute renal failure: a prospective, double-blind, placebo-controlled, randomized study. Nephrol Dial Transplant 12:2592–2596PubMedCrossRefGoogle Scholar
  99. 99.
    Sirivella S, Gielchinsky I, Parsonnet V (2000) Mannitol, furosemide, and dopamine infusion in postoperative renal failure complicating cardiac surgery. Ann Thorac Surg 69:501–506PubMedCrossRefGoogle Scholar
  100. 100.
    Ho KM, Sheridan DJ (2006) Meta-analysis of frusemide to prevent or treat acute renal failure. BMJ 333:420PubMedCrossRefGoogle Scholar
  101. 101.
    Bagshaw SM, Delaney A, Haase M, Ghali WA, Bellomo R (2007) Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis. Crit Care Resusc 9:60–68PubMedGoogle Scholar
  102. 102.
    Sampath S, Moran JL, Graham PL, Rockliff S, Bersten AD, Abrams KR (2007) The efficacy of loop diuretics in acute renal failure: assessment using Bayesian evidence synthesis techniques. Crit Care Med 35:2516–2524PubMedCrossRefGoogle Scholar
  103. 103.
    Mehta RL, Pascual MT, Soroko S, Chertow GM (2002) Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 288:2547–2553PubMedCrossRefGoogle Scholar
  104. 104.
    Uchino S, Doig GS, Bellomo R, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Nacedo E, Gibney N, Tolwani A, Ronco C, Kellum JA (2004) Diuretics and mortality in acute renal failure. Crit Care Med 32:1669–1677PubMedCrossRefGoogle Scholar
  105. 105.
    Dünser MW, Takala J, Ulmer H, Mayr VD, Luckner G, Jochberger S, Daudel F, Lepper P, Hasibeder WR, Jakob SM (2009) Arterial blood pressure during early sepsis and outcome. Intensive Care Med 35:1225–1233PubMedCrossRefGoogle Scholar
  106. 106.
    Bourgoin A, Leone M, Delmas A, Garnier F, Albanese J, Martin C (2005) Increasing mean arterial pressure in patients with septic shock: effects on oxygen variables and renal function. Crit Care Med 33:780–786PubMedCrossRefGoogle Scholar
  107. 107.
    Holmes CL, Walley KR (2003) Bad medicine: low-dose dopamine in the ICU. Chest 123:1266–1275PubMedCrossRefGoogle Scholar
  108. 108.
    Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J (2000) Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 356:2139–2143PubMedCrossRefGoogle Scholar
  109. 109.
    Friedrich JO, Adhikari N, Herridge MS, Beyene J (2005) Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med 142:510–524PubMedGoogle Scholar
  110. 110.
    Girbes AR, Patten MT, McCloskey BV, Groeneveld AB, Hoogenberg K (2000) The renal and neurohumoral effects of the addition of low-dose dopamine in septic critically ill patients. Intensive Care Med 26:1685–1689PubMedCrossRefGoogle Scholar
  111. 111.
    Ichai C, Soubielle J, Carles M, Giunti C, Grimaud D (2000) Comparison of the renal effects of low to high doses of dopamine and dobutamine in critically ill patients: a single-blind randomized study. Crit Care Med 28:921–928PubMedCrossRefGoogle Scholar
  112. 112.
    Karthik S, Lisbon A (2006) Low-dose dopamine in the intensive care unit. Semin Dial 19:465–471PubMedCrossRefGoogle Scholar
  113. 113.
    Renton MC, Snowden CP (2005) Dopexamine and its role in the protection of hepatosplanchnic and renal perfusion in high-risk surgical and critically ill patients. Br J Anaesth 94:459–467PubMedCrossRefGoogle Scholar
  114. 114.
    Albanese J, Leone M, Garnier F, Bourgoin A, Antonini F, Martin C (2004) Renal effects of norepinephrine in septic and nonseptic patients. Chest 126:534–539PubMedCrossRefGoogle Scholar
  115. 115.
    Delmas A, Leone M, Rousseau S, Albanese J, Martin C (2005) Clinical review: Vasopressin and terlipressin in septic shock patients. Crit Care 9:212–222PubMedCrossRefGoogle Scholar
  116. 116.
    Russell JA, Walley KR, Singer J, Gordon AC, Hebert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D (2008) Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 358:877–887PubMedCrossRefGoogle Scholar
  117. 117.
    Brezis M, Rosen S (1995) Hypoxia of the renal medulla—its implications for disease. N Engl J Med 332:647–655PubMedCrossRefGoogle Scholar
  118. 118.
    Cohen RI, Hassell AM, Marzouk K, Marini C, Liu SF, Scharf SM (2001) Renal effects of nitric oxide in endotoxemia. Am J Respir Crit Care Med 164:1890–1895PubMedGoogle Scholar
  119. 119.
    Lameire NH, Matthys E, Kesteloot D, Waterloos MA (1990) Effect of a serotonin blocking agent on renal hemodynamics in the normal rat. Kidney Int 38:823–829PubMedCrossRefGoogle Scholar
  120. 120.
    Linas S, Whittenburg D, Repine JE (1997) Nitric oxide prevents neutrophil-mediated acute renal failure. Am J Physiol 272:F48–F54PubMedGoogle Scholar
  121. 121.
    Zhang H, Rogiers P, Smail N, Cabral A, Preiser JC, Peny MO, Vincent JL (1997) Effects of nitric oxide on blood flow distribution and O2 extraction capabilities during endotoxic shock. J Appl Physiol 83:1164–1173PubMedGoogle Scholar
  122. 122.
    Brienza N, Malcangi V, Dalfino L, Trerotoli P, Guagliardi C, Bortone D, Faconda G, Ribezzi M, Ancona G, Bruno F, Fiore T (2006) A comparison between fenoldopam and low-dose dopamine in early renal dysfunction of critically ill patients. Crit Care Med 34:707–714PubMedCrossRefGoogle Scholar
  123. 123.
    Morelli A, Ricci Z, Bellomo R, Ronco C, Rocco M, Conti G, De GA, Picchini U, Orecchioni A, Portieri M, Coluzzi F, Porzi P, Serio P, Bruno A, Pietropaoli P (2005) Prophylactic fenoldopam for renal protection in sepsis: a randomized, double-blind, placebo-controlled pilot trial. Crit Care Med 33:2451–2456PubMedCrossRefGoogle Scholar
  124. 124.
    Tumlin JA, Finkel KW, Murray PT, Samuels J, Cotsonis G, Shaw AD (2005) Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. Am J Kidney Dis 46:26–34PubMedCrossRefGoogle Scholar
  125. 125.
    Landoni G, Biondi-Zoccai GG, Marino G, Bove T, Fochi O, Maj G, Calabro MG, Sheiban I, Tumlin JA, Ranucci M, Zangrillo A (2008) Fenoldopam reduces the need for renal replacement therapy and in-hospital death in cardiovascular surgery: a meta-analysis. J Cardiothorac Vasc Anesth 22:27–33PubMedCrossRefGoogle Scholar
  126. 126.
    Landoni G, Biondi-Zoccai GG, Tumlin JA, Bove T, De LM, Calabro MG, Ranucci M, Zangrillo A (2007) Beneficial impact of fenoldopam in critically ill patients with or at risk for acute renal failure: a meta-analysis of randomized clinical trials. Am J Kidney Dis 49:56–68PubMedCrossRefGoogle Scholar
  127. 127.
    Allaqaband S, Tumuluri R, Malik AM, Gupta A, Volkert P, Shalev Y, Bajwa TK (2002) Prospective randomized study of N-acetylcysteine, fenoldopam, and saline for prevention of radiocontrast-induced nephropathy. Catheter Cardiovasc Interv 57:279–283PubMedCrossRefGoogle Scholar
  128. 128.
    Stone GW, McCullough PA, Tumlin JA, Lepor NE, Madyoon H, Murray P, Wang A, Chu AA, Schaer GL, Stevens M, Wilensky RL, O’Neill WW (2003) Fenoldopam mesylate for the prevention of contrast-induced nephropathy: a randomized controlled trial. JAMA 290:2284–2291PubMedCrossRefGoogle Scholar
  129. 129.
    Kulka PJ, Tryba M, Zenz M (1996) Preoperative alpha2-adrenergic receptor agonists prevent the deterioration of renal function after cardiac surgery: results of a randomized, controlled trial. Crit Care Med 24:947–952PubMedCrossRefGoogle Scholar
  130. 130.
    Myles PS, Hunt JO, Holdgaard HO, McRae R, Buckland MR, Moloney J, Hall J, Bujor MA, Esmore DS, Davis BB, Morgan DJ (1999) Clonidine and cardiac surgery: haemodynamic and metabolic effects, myocardial ischaemia and recovery. Anaesth Intensive Care 27:137–147PubMedGoogle Scholar
  131. 131.
    Sward K, Valsson F, Sellgren J, Ricksten SE (2005) Differential effects of human atrial natriuretic peptide and furosemide on glomerular filtration rate and renal oxygen consumption in humans. Intensive Care Med 31:79–85PubMedCrossRefGoogle Scholar
  132. 132.
    Allgren RL, Marbury TC, Rahman SN, Weisberg LS, Fenves AZ, Lafayette RA, Sweet RM, Genter FC, Kurnik BR, Conger JD, Sayegh MH (1997) Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group. N Engl J Med 336:828–834PubMedCrossRefGoogle Scholar
  133. 133.
    Lewis J, Salem MM, Chertow GM, Weisberg LS, McGrew F, Marbury TC, Allgren RL (2000) Atrial natriuretic factor in oliguric acute renal failure. Anaritide Acute Renal Failure Study Group. Am J Kidney Dis 36:767–774PubMedCrossRefGoogle Scholar
  134. 134.
    Rahman SN, Kim GE, Mathew AS, Goldberg CA, Allgren R, Schrier RW, Conger JD (1994) Effects of atrial natriuretic peptide in clinical acute renal failure. Kidney Int 45:1731–1738PubMedCrossRefGoogle Scholar
  135. 135.
    Meyer M, Pfarr E, Schirmer G, Uberbacher HJ, Schope K, Bohm E, Fluge T, Mentz P, Scigalla P, Forssmann WG (1999) Therapeutic use of the natriuretic peptide ularitide in acute renal failure. Ren Fail 21:85–100PubMedCrossRefGoogle Scholar
  136. 136.
    Sward K, Valsson F, Odencrants P, Samuelsson O, Ricksten SE (2004) Recombinant human atrial natriuretic peptide in ischemic acute renal failure: a randomized placebo-controlled trial. Crit Care Med 32:1310–1315PubMedCrossRefGoogle Scholar
  137. 137.
    Mentzer RM Jr, Oz MC, Sladen RN, Graeve AH, Hebeler RF Jr, Luber JM Jr, Smedira NG (2007) Effects of perioperative nesiritide in patients with left ventricular dysfunction undergoing cardiac surgery: the NAPA trial. J Am Coll Cardiol 49:716–726PubMedCrossRefGoogle Scholar
  138. 138.
    Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T (2008) Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair. Crit Care Med 36:745–751PubMedCrossRefGoogle Scholar
  139. 139.
    Chen HH, Sundt TM, Cook DJ, Heublein DM, Burnett JC Jr (2007) Low dose nesiritide and the preservation of renal function in patients with renal dysfunction undergoing cardiopulmonary-bypass surgery: a double-blind placebo-controlled pilot study. Circulation 116:I134–I138PubMedCrossRefGoogle Scholar
  140. 140.
    Sackner-Bernstein JD, Kowalski M, Fox M, Aaronson K (2005) Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials. JAMA 293:1900–1905PubMedCrossRefGoogle Scholar
  141. 141.
    Abizaid AS, Clark CE, Mintz GS, Dosa S, Popma JJ, Pichard AD, Satler LF, Harvey M, Kent KM, Leon MB (1999) Effects of dopamine and aminophylline on contrast-induced acute renal failure after coronary angioplasty in patients with preexisting renal insufficiency. Am J Cardiol 83:260–263 A5PubMedCrossRefGoogle Scholar
  142. 142.
    Bagshaw SM, Ghali WA (2005) Theophylline for prevention of contrast-induced nephropathy: a systematic review and meta-analysis. Arch Intern Med 165:1087–1093PubMedCrossRefGoogle Scholar
  143. 143.
    Erley CM, Duda SH, Schlepckow S, Koehler J, Huppert PE, Strohmaier WL, Bohle A, Risler T, Osswald H (1994) Adenosine antagonist theophylline prevents the reduction of glomerular filtration rate after contrast media application. Kidney Int 45:1425–1431PubMedCrossRefGoogle Scholar
  144. 144.
    Erley CM, Duda SH, Rehfuss D, Scholtes B, Bock J, Muller C, Osswald H, Risler T (1999) Prevention of radiocontrast-media-induced nephropathy in patients with pre-existing renal insufficiency by hydration in combination with the adenosine antagonist theophylline. Nephrol Dial Transplant 14:1146–1149PubMedCrossRefGoogle Scholar
  145. 145.
    Huber W, Ilgmann K, Page M, Hennig M, Schweigart U, Jeschke B, Lutilsky L, Weiss W, Salmhofer H, Classen M (2002) Effect of theophylline on contrast material-nephropathy in patients with chronic renal insufficiency: controlled, randomized, double-blinded study. Radiology 223:772–779PubMedCrossRefGoogle Scholar
  146. 146.
    Huber W, Schipek C, Ilgmann K, Page M, Hennig M, Wacker A, Schweigart U, Lutilsky L, Valina C, Seyfarth M, Schomig A, Classen M (2003) Effectiveness of theophylline prophylaxis of renal impairment after coronary angiography in patients with chronic renal insufficiency. Am J Cardiol 91:1157–1162PubMedCrossRefGoogle Scholar
  147. 147.
    Ix JH, McCulloch CE, Chertow GM (2004) Theophylline for the prevention of radiocontrast nephropathy: a meta-analysis. Nephrol Dial Transplant 19:2747–2753PubMedCrossRefGoogle Scholar
  148. 148.
    Kapoor A, Kumar S, Gulati S, Gambhir S, Sethi RS, Sinha N (2002) The role of theophylline in contrast-induced nephropathy: a case–control study. Nephrol Dial Transplant 17:1936–1941PubMedCrossRefGoogle Scholar
  149. 149.
    Katholi RE, Taylor GJ, McCann WP, Woods WT Jr, Womack KA, McCoy CD, Katholi CR, Moses HW, Mishkel GJ, Lucore CL (1995) Nephrotoxicity from contrast media: attenuation with theophylline. Radiology 195:17–22PubMedGoogle Scholar
  150. 150.
    Kolonko A, Wiecek A, Kokot F (1998) The nonselective adenosine antagonist theophylline does prevent renal dysfunction induced by radiographic contrast agents. J Nephrol 11:151–156PubMedGoogle Scholar
  151. 151.
    Huber W, Eckel F, Hennig M, Rosenbrock H, Wacker A, Saur D, Sennefelder A, Hennico R, Schenk C, Meining A, Schmelz R, Fritsch R, Weiss W, Hamar P, Heemann U, Schmid RM (2006) Prophylaxis of contrast material-induced nephropathy in patients in intensive care: acetylcysteine, theophylline, or both? A randomized study. Radiology 239:793–804PubMedCrossRefGoogle Scholar
  152. 152.
    Kelly AM, Dwamena B, Cronin P, Bernstein SJ, Carlos RC (2008) Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Ann Intern Med 148:284–294PubMedGoogle Scholar
  153. 153.
    Kleinschmidt S, Bauer M, Grundmann U, Schneider A, Wagner B, Graeter T (1997) Effect of gamma-hydroxybutyric acid and pentoxifylline on kidney function parameters in coronary surgery interventions. Anaesthesiol Reanim 22:102–107PubMedGoogle Scholar
  154. 154.
    Boldt J, Brosch C, Piper SN, Suttner S, Lehmann A, Werling C (2001) Influence of prophylactic use of pentoxifylline on postoperative organ function in elderly cardiac surgery patients. Crit Care Med 29:952–958PubMedCrossRefGoogle Scholar
  155. 155.
    Hoffmann H, Markewitz A, Kreuzer E, Reichert K, Jochum M, Faist E (1998) Pentoxifylline decreases the incidence of multiple organ failure in patients after major cardio-thoracic surgery. Shock 9:235–240PubMedCrossRefGoogle Scholar
  156. 156.
    Boldt J, Brosch C, Suttner S, Piper SN, Lehmann A, Werling C (2002) Prophylactic use of the phospodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function. Intensive Care Med 28:1462–1469PubMedCrossRefGoogle Scholar
  157. 157.
    Boldt J, Brosch C, Lehmann A, Suttner S, Isgro F (2004) The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients. Anesth Analg 99:1009–1017 (table)PubMedCrossRefGoogle Scholar
  158. 158.
    Yilmaz MB, Yalta K, Yontar C, Karadas F, Erdem A, Turgut OO, Yilmaz A, Tandogan I (2007) Levosimendan improves renal function in patients with acute decompensated heart failure: comparison with dobutamine. Cardiovasc Drugs Ther 21:431–435PubMedCrossRefGoogle Scholar
  159. 159.
    Sketch MH Jr, Whelton A, Schollmayer E, Koch JA, Bernink PJ, Woltering F, Brinker J (2001) Prevention of contrast media-induced renal dysfunction with prostaglandin E1: a randomized, double-blind, placebo-controlled study. Am J Ther 8:155–162PubMedCrossRefGoogle Scholar
  160. 160.
    Koch JA, Plum J, Grabensee B, Modder U (2000) Prostaglandin E1: a new agent for the prevention of renal dysfunction in high risk patients caused by radiocontrast media? PGE1 Study Group. Nephrol Dial Transplant 15:43–49PubMedCrossRefGoogle Scholar
  161. 161.
    Spargias K, Adreanides E, Giamouzis G, Karagiannis S, Gouziouta A, Manginas A, Voudris V, Pavlides G, Cokkinos DV (2006) Iloprost for prevention of contrast-mediated nephropathy in high-risk patients undergoing a coronary procedure. Results of a randomized pilot study. Eur J Clin Pharmacol 62:589–595PubMedCrossRefGoogle Scholar
  162. 162.
    Norman JT, Stidwill R, Singer M, Fine LG (2003) Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action. Nephron Physiol 94:39–46CrossRefGoogle Scholar
  163. 163.
    Tiefenbacher CP, Friedrich S, Bleeke T, Vahl C, Chen X, Niroomand F (2004) ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles. Am J Physiol Heart Circ Physiol 286:H1425–H1432PubMedCrossRefGoogle Scholar
  164. 164.
    Ryckwaert F, Colson P, Ribstein J, Boccara G, Guillon G (2001) Haemodynamic and renal effects of intravenous enalaprilat during coronary artery bypass graft surgery in patients with ischaemic heart dysfunction. Br J Anaesth 86:169–175PubMedCrossRefGoogle Scholar
  165. 165.
    Wagner F, Yeter R, Bisson S, Siniawski H, Hetzer R (2003) Beneficial hemodynamic and renal effects of intravenous enalaprilat following coronary artery bypass surgery complicated by left ventricular dysfunction. Crit Care Med 31:1421–1428PubMedCrossRefGoogle Scholar
  166. 166.
    Fioretto P, Bruseghin M, Berto I, Gallina P, Manzato E, Mussap M (2006) Renal protection in diabetes: role of glycemic control. J Am Soc Nephrol 17:S86–S89PubMedCrossRefGoogle Scholar
  167. 167.
    Ding H, Kopple JD, Cohen A, Hirschberg R (1993) Recombinant human insulin-like growth factor-I accelerates recovery and reduces catabolism in rats with ischemic acute renal failure. J Clin Invest 91:2281–2287PubMedCrossRefGoogle Scholar
  168. 168.
    Miller SB, Martin DR, Kissane J, Hammerman MR (1992) Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat. Proc Natl Acad Sci USA 89:11876–11880PubMedCrossRefGoogle Scholar
  169. 169.
    Yasuda H, Kato A, Miyaji T, Zhou H, Togawa A, Hishida A (2004) Insulin-like growth factor-I increases p21 expression and attenuates cisplatin-induced acute renal injury in rats. Clin Exp Nephrol 8:27–35PubMedCrossRefGoogle Scholar
  170. 170.
    Michael UF, Logan JL, Meeks LA (1991) The beneficial effects of thyroxine on nephrotoxic acute renal failure in the rat. J Am Soc Nephrol 1:1236–1240PubMedGoogle Scholar
  171. 171.
    Sutter PM, Thulin G, Stromski M, Ardito T, Gaudio KM, Kashgarian M, Siegel NJ (1988) Beneficial effect of thyroxin in the treatment of ischemic acute renal failure. Pediatr Nephrol 2:1–7PubMedCrossRefGoogle Scholar
  172. 172.
    Chatterjee PK (2005) Pleiotropic renal actions of erythropoietin. Lancet 365:1890–1892PubMedCrossRefGoogle Scholar
  173. 173.
    Coleman T, Brines M (2004) Science review: recombinant human erythropoietin in critical illness: a role beyond anemia? Crit Care 8:337–341PubMedCrossRefGoogle Scholar
  174. 174.
    Bernhardt WM, Eckardt KU (2008) Physiological basis for the use of erythropoietin in critically ill patients at risk for acute kidney injury. Curr Opin Crit Care 14:621–626PubMedCrossRefGoogle Scholar
  175. 175.
    Bahlmann FH, Fliser D (2009) Erythropoietin and renoprotection. Curr Opin Nephrol Hypertens 18:15–20PubMedCrossRefGoogle Scholar
  176. 176.
    Jungers P, Choukroun G, Oualim Z, Robino C, Nguyen AT, Man NK (2001) Beneficial influence of recombinant human erythropoietin therapy on the rate of progression of chronic renal failure in predialysis patients. Nephrol Dial Transplant 16:307–312PubMedCrossRefGoogle Scholar
  177. 177.
    Maiese K, Chong ZZ, Shang YC (2008) Raves and risks for erythropoietin. Cytokine Growth Factor Rev 19:145–155PubMedCrossRefGoogle Scholar
  178. 178.
    Yokomaku Y, Sugimoto T, Kume S, Araki S, Isshiki K, Chin-Kanasaki M, Sakaguchi M, Nitta N, Haneda M, Koya D, Uzu T, Kashiwagi A (2008) Asialoerythropoietin prevents contrast-induced nephropathy. J Am Soc Nephrol 19:321–328PubMedCrossRefGoogle Scholar
  179. 179.
    Mizutani A, Okajima K, Uchiba M, Noguchi T (2000) Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 95:3781–3787PubMedGoogle Scholar
  180. 180.
    Gupta A, Berg DT, Gerlitz B, Sharma GR, Syed S, Richardson MA, Sandusky G, Heuer JG, Galbreath EJ, Grinnell BW (2007) Role of protein C in renal dysfunction after polymicrobial sepsis. J Am Soc Nephrol 18:860–867PubMedCrossRefGoogle Scholar
  181. 181.
    Gupta A, Rhodes GJ, Berg DT, Gerlitz B, Molitoris BA, Grinnell BW (2007) Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2. Am J Physiol Renal Physiol 293:F245–F254PubMedCrossRefGoogle Scholar
  182. 182.
    Gupta A, Gerlitz B, Richardson MA, Bull C, Berg DT, Syed S, Galbreath EJ, Swanson BA, Jones BE, Grinnell BW (2009) Distinct functions of activated protein C differentially attenuate acute kidney injury. J Am Soc Nephrol 20:267–277PubMedCrossRefGoogle Scholar
  183. 183.
    van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R (2001) Intensive insulin therapy in the critically ill patients. N Engl J Med 345:1359–1367PubMedCrossRefGoogle Scholar
  184. 184.
    van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van WE, Bobbaers H, Bouillon R (2006) Intensive insulin therapy in the medical ICU. N Engl J Med 354:449–461PubMedCrossRefGoogle Scholar
  185. 185.
    Schetz M, Vanhorebeek I, Wouters PJ, Wilmer A, van den BG (2008) Tight blood glucose control is renoprotective in critically ill patients. J Am Soc Nephrol 19:571–578Google Scholar
  186. 186.
    Krinsley JS (2004) Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 79:992–1000PubMedCrossRefGoogle Scholar
  187. 187.
    Lecomte P, Van VB, Coddens J, Cammu G, Nollet G, Nobels F, Vanermen H, Foubert L (2008) Tight perioperative glucose control is associated with a reduction in renal impairment and renal failure in non-diabetic cardiac surgical patients. Crit Care 12:R154PubMedCrossRefGoogle Scholar
  188. 188.
    Griesdale DE, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finfer S, Talmor D (2009) Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ 180:821–827PubMedGoogle Scholar
  189. 189.
    Arabi YM, Dabbagh OC, Tamim HM, Al-Shimemeri AA, Memish ZA, Haddad SH, Syed SJ, Giridhar HR, Rishu AH, Al-Daker MO, Kahoul SH, Britts RJ, Sakkijha MH (2008) Intensive versus conventional insulin therapy: a randomized controlled trial in medical and surgical critically ill patients. Crit Care Med 36:3190–3197PubMedCrossRefGoogle Scholar
  190. 190.
    Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hebert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ (2009) Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360:1283–1297PubMedCrossRefGoogle Scholar
  191. 191.
    Wiener RS, Wiener DC, Larson RJ (2008) Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA 300:933–944PubMedCrossRefGoogle Scholar
  192. 192.
    van den Berghe G, Schetz M, Vlasselaers D, Hermans G, Wilmer A, Bouillon R, Mesotten D (2009) Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target? J Clin Endocrinol Metab 94:3163–3170PubMedCrossRefGoogle Scholar
  193. 193.
    Hirschberg R, Kopple J, Lipsett P, Benjamin E, Minei J, Albertson T, Munger M, Metzler M, Zaloga G, Murray M, Lowry S, Conger J, McKeown W, O’shea M, Baughman R, Wood K, Haupt M, Kaiser R, Simms H, Warnock D, Summer W, Hintz R, Myers B, Haenftling K, Capra W (1999) Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure. Kidney Int 55:2423–2432PubMedCrossRefGoogle Scholar
  194. 194.
    Franklin SC, Moulton M, Sicard GA, Hammerman MR, Miller SB (1997) Insulin-like growth factor I preserves renal function postoperatively. Am J Physiol 272:F257–F259PubMedGoogle Scholar
  195. 195.
    Acker CG, Singh AR, Flick RP, Bernardini J, Greenberg A, Johnson JP (2000) A trial of thyroxine in acute renal failure. Kidney Int 57:293–298PubMedCrossRefGoogle Scholar
  196. 196.
    Loef BG, Henning RH, Epema AH, Rietman GW, van OW, Navis GJ, Ebels T (2004) Effect of dexamethasone on perioperative renal function impairment during cardiac surgery with cardiopulmonary bypass. Br J Anaesth 93:793–798Google Scholar
  197. 197.
    Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344:699–709PubMedCrossRefGoogle Scholar
  198. 198.
    Vincent JL, Angus DC, Artigas A, Kalil A, Basson BR, Jamal HH, Johnson G III, Bernard GR (2003) Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 31:834–840PubMedCrossRefGoogle Scholar
  199. 199.
    Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Shapiro MJ, Corwin MJ, Colton T (2002) Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA 288:2827–2835PubMedCrossRefGoogle Scholar
  200. 200.
    Pons M, Plante I, LeBrun M, Gourde P, Simard M, Grenier L, Thibault L, Labrecque G, Beauchamp D (2003) Protein-rich diet attenuates cyclosporin A-induced renal tubular damage in rats. J Ren Nutr 13:84–92PubMedCrossRefGoogle Scholar
  201. 201.
    Roberts PR, Black KW, Zaloga GP (1997) Enteral feeding improves outcome and protects against glycerol-induced acute renal failure in the rat. Am J Respir Crit Care Med 156:1265–1269PubMedGoogle Scholar
  202. 202.
    Zager RA (1987) Amino acid hyperalimentation in acute renal failure: a potential therapeutic paradox. Kidney Int Suppl 22:S72–S75PubMedGoogle Scholar
  203. 203.
    Evans RG, Fitzgerald SM (2005) Nitric oxide and superoxide in the renal medulla: a delicate balancing act. Curr Opin Nephrol Hypertens 14:9–15PubMedCrossRefGoogle Scholar
  204. 204.
    Haque MZ, Majid DS (2004) Assessment of renal functional phenotype in mice lacking gp91PHOX subunit of NAD(P)H oxidase. Hypertension 43:335–340PubMedCrossRefGoogle Scholar
  205. 205.
    Haugen E, Nath KA (1999) The involvement of oxidative stress in the progression of renal injury. Blood Purif 17:58–65PubMedCrossRefGoogle Scholar
  206. 206.
    Vaziri ND (2004) Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertension. Curr Opin Nephrol Hypertens 13:93–99PubMedCrossRefGoogle Scholar
  207. 207.
    Abel RM, Beck CH Jr, Abbott WM, Ryan JA Jr, Barnett GO, Fischer JE (1973) Improved survival from acute renal failure after treatment with intravenous essential L-amino acids and glucose. Results of a prospective, double-blind study. N Engl J Med 288:695–699PubMedCrossRefGoogle Scholar
  208. 208.
    Badalamenti S, Gines P, Arroyo V, Llach J, Piera C, Rimola A, Jimenez W, Gaya J, Casamitjana R, Rivera F (1990) Effects of intravenous amino acid infusion and dietary proteins on kidney function in cirrhosis. Hepatology 11:379–386PubMedCrossRefGoogle Scholar
  209. 209.
    Mouser JF, Hak EB, Kuhl DA, Dickerson RN, Gaber LW, Hak LJ (1997) Recovery from ischemic acute renal failure is improved with enteral compared with parenteral nutrition. Crit Care Med 25:1748–1754PubMedCrossRefGoogle Scholar
  210. 210.
    Heyman SN, Goldfarb M, Shina A, Karmeli F, Rosen S (2003) N-Acetylcysteine ameliorates renal microcirculation: studies in rats. Kidney Int 63:634–641PubMedCrossRefGoogle Scholar
  211. 211.
    Borgstrom L, Kagedal B, Paulsen O (1986) Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol 31:217–222PubMedCrossRefGoogle Scholar
  212. 212.
    Olsson B, Johansson M, Gabrielsson J, Bolme P (1988) Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 34:77–82PubMedCrossRefGoogle Scholar
  213. 213.
    Tepel M, van der GM, Schwarzfeld C, Laufer U, Liermann D, Zidek W (2000) Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 343:180–184Google Scholar
  214. 214.
    Baker CS, Wragg A, Kumar S, De PR, Baker LR, Knight CJ (2003) A rapid protocol for the prevention of contrast-induced renal dysfunction: the RAPPID study. J Am Coll Cardiol 41:2114–2118PubMedCrossRefGoogle Scholar
  215. 215.
    Briguori C, Manganelli F, Scarpato P, Elia PP, Golia B, Riviezzo G, Lepore S, Librera M, Villari B, Colombo A, Ricciardelli B (2002) Acetylcysteine and contrast agent-associated nephrotoxicity. J Am Coll Cardiol 40:298–303PubMedCrossRefGoogle Scholar
  216. 216.
    Durham JD, Caputo C, Dokko J, Zaharakis T, Pahlavan M, Keltz J, Dutka P, Marzo K, Maesaka JK, Fishbane S (2002) A randomized controlled trial of N-acetylcysteine to prevent contrast nephropathy in cardiac angiography. Kidney Int 62:2202–2207PubMedCrossRefGoogle Scholar
  217. 217.
    Kay J, Chow WH, Chan TM, Lo SK, Kwok OH, Yip A, Fan K, Lee CH, Lam WF (2003) Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial. JAMA 289:553–558PubMedCrossRefGoogle Scholar
  218. 218.
    MacNeill BD, Harding SA, Bazari H, Patton KK, Colon-Hernadez P, DeJoseph D, Jang IK (2003) Prophylaxis of contrast-induced nephropathy in patients undergoing coronary angiography. Catheter Cardiovasc Interv 60:458–461PubMedCrossRefGoogle Scholar
  219. 219.
    Miner SE, Dzavik V, Nguyen-Ho P, Richardson R, Mitchell J, Atchison D, Seidelin P, Daly P, Ross J, McLaughlin PR, Ing D, Lewycky P, Barolet A, Schwartz L (2004) N-acetylcysteine reduces contrast-associated nephropathy but not clinical events during long-term follow-up. Am Heart J 148:690–695PubMedCrossRefGoogle Scholar
  220. 220.
    Oldemeyer JB, Biddle WP, Wurdeman RL, Mooss AN, Cichowski E, Hilleman DE (2003) Acetylcysteine in the prevention of contrast-induced nephropathy after coronary angiography. Am Heart J 146:E23PubMedCrossRefGoogle Scholar
  221. 221.
    Shyu KG, Cheng JJ, Kuan P (2002) Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure. J Am Coll Cardiol 40:1383–1388PubMedCrossRefGoogle Scholar
  222. 222.
    Vallero A, Cesano G, Pozzato M, Garbo R, Minelli M, Quarello F, Formica M (2002) Contrast nephropathy in cardiac procedures: no advantages with prophylactic use of N-acetylcysteine (NAC). G Ital Nefrol 19:529–533PubMedGoogle Scholar
  223. 223.
    Gonzales DA, Norsworthy KJ, Kern SJ, Banks S, Sieving PC, Star RA, Natanson C, Danner RL (2007) A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med 5:32PubMedCrossRefGoogle Scholar
  224. 224.
    Gawenda M, Moller A, Wassmer G, Brunkwall J (2007) Prophylaxis of contrast-induced nephropathy with N-acetylcysteine. Zentralbl Chir 132:227–231PubMedCrossRefGoogle Scholar
  225. 225.
    Zagler A, Azadpour M, Mercado C, Hennekens CH (2006) N-acetylcysteine and contrast-induced nephropathy: a meta-analysis of 13 randomized trials. Am Heart J 151:140–145PubMedCrossRefGoogle Scholar
  226. 226.
    Duong MH, MacKenzie TA, Malenka DJ (2005) N-acetylcysteine prophylaxis significantly reduces the risk of radiocontrast-induced nephropathy: comprehensive meta-analysis. Catheter Cardiovasc Interv 64:471–479PubMedCrossRefGoogle Scholar
  227. 227.
    Pannu N, Manns B, Lee H, Tonelli M (2004) Systematic review of the impact of N-acetylcysteine on contrast nephropathy. Kidney Int 65:1366–1374PubMedCrossRefGoogle Scholar
  228. 228.
    Alonso A, Lau J, Jaber BL, Weintraub A, Sarnak MJ (2004) Prevention of radiocontrast nephropathy with N-acetylcysteine in patients with chronic kidney disease: a meta-analysis of randomized, controlled trials. Am J Kidney Dis 43:1–9PubMedCrossRefGoogle Scholar
  229. 229.
    Hoffmann U, Fischereder M, Kruger B, Drobnik W, Kramer BK (2004) The value of N-acetylcysteine in the prevention of radiocontrast agent-induced nephropathy seems questionable. J Am Soc Nephrol 15:407–410PubMedCrossRefGoogle Scholar
  230. 230.
    Rank N, Michel C, Haertel C, Lenhart A, Welte M, Meier-Hellmann A, Spies C (2000) N-Acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. Crit Care Med 28:3799–3807PubMedCrossRefGoogle Scholar
  231. 231.
    Poletti PA, Saudan P, Platon A, Mermillod B, Sautter AM, Vermeulen B, Sarasin FP, Becker CD, Martin PY (2007) I.v. N-acetylcysteine and emergency CT: use of serum creatinine and cystatin C as markers of radiocontrast nephrotoxicity. AJR Am J Roentgenol 189:687–692PubMedCrossRefGoogle Scholar
  232. 232.
    Chen SL, Zhang J, Yei F, Zhu Z, Liu Z, Lin S, Chu J, Yan J, Zhang R, Kwan TW (2008) Clinical outcomes of contrast-induced nephropathy in patients undergoing percutaneous coronary intervention: a prospective, multicenter, randomized study to analyze the effect of hydration and acetylcysteine. Int J Cardiol 126:407–413PubMedCrossRefGoogle Scholar
  233. 233.
    Rashid ST, Salman M, Myint F, Baker DM, Agarwal S, Sweny P, Hamilton G (2004) Prevention of contrast-induced nephropathy in vascular patients undergoing angiography: a randomized controlled trial of intravenous N-acetylcysteine. J Vasc Surg 40:1136–1141PubMedCrossRefGoogle Scholar
  234. 234.
    Lawlor DK, Moist L, DeRose G, Harris KA, Lovell MB, Kribs SW, Elliot J, Forbes TL (2007) Prevention of contrast-induced nephropathy in vascular surgery patients. Ann Vasc Surg 21:593–597PubMedCrossRefGoogle Scholar
  235. 235.
    Coyle LC, Rodriguez A, Jeschke RE, Simon-Lee A, Abbott KC, Taylor AJ (2006) Acetylcysteine In Diabetes (AID): a randomized study of acetylcysteine for the prevention of contrast nephropathy in diabetics. Am Heart J 151:12–1032CrossRefGoogle Scholar
  236. 236.
    Heng AE, Cellarier E, Aublet-Cuvelier B, Decalf V, Motreff P, Marcaggi X, Deteix P, Souweine B (2008) Is treatment with N-acetylcysteine to prevent contrast-induced nephropathy when using bicarbonate hydration out of date? Clin Nephrol 70:475–484PubMedGoogle Scholar
  237. 237.
    Staniloae CS, Doucet S, Sharma SK, Katholi RE, Mody KR, Coppola JT, Solomon R (2009) N-Acetylcysteine added to volume expansion with sodium bicarbonate does not further prevent contrast-induced nephropathy: results from the cardiac angiography in renally impaired patients study. J Interv Cardiol 22:261–265PubMedCrossRefGoogle Scholar
  238. 238.
    Fung JW, Szeto CC, Chan WW, Kum LC, Chan AK, Wong JT, Wu EB, Yip GW, Chan JY, Yu CM, Woo KS, Sanderson JE (2004) Effect of N-acetylcysteine for prevention of contrast nephropathy in patients with moderate to severe renal insufficiency: a randomized trial. Am J Kidney Dis 43:801–808PubMedCrossRefGoogle Scholar
  239. 239.
    Gomes VO, Poli de Figueredo CE, Caramori P, Lasevitch R, Bodanese LC, Araujo A, Roedel AP, Caramori AP, Brito FS Jr, Bezerra HG, Nery P, Brizolara A (2005) N-Acetylcysteine does not prevent contrast induced nephropathy after cardiac catheterisation with an ionic low osmolality contrast medium: a multicentre clinical trial. Heart 91:774–778PubMedCrossRefGoogle Scholar
  240. 240.
    Ristikankare A, Kuitunen T, Kuitunen A, Uotila L, Vento A, Suojaranta-Ylinen R, Salmenpera M, Poyhia R (2006) Lack of renoprotective effect of i.v. N-acetylcysteine in patients with chronic renal failure undergoing cardiac surgery. Br J Anaesth 97:611–616PubMedCrossRefGoogle Scholar
  241. 241.
    Burns KE, Chu MW, Novick RJ, Fox SA, Gallo K, Martin CM, Stitt LW, Heidenheim AP, Myers ML, Moist L (2005) Perioperative N-acetylcysteine to prevent renal dysfunction in high-risk patients undergoing CABG surgery: a randomized controlled trial. JAMA 294:342–350PubMedCrossRefGoogle Scholar
  242. 242.
    Macedo E, Abdulkader R, Castro I, Sobrinho AC, Yu L, Vieira JM Jr (2006) Lack of protection of N-acetylcysteine (NAC) in acute renal failure related to elective aortic aneurysm repair-a randomized controlled trial. Nephrol Dial Transplant 21:1863–1869PubMedCrossRefGoogle Scholar
  243. 243.
    Komisarof JA, Gilkey GM, Peters DM, Koudelka CW, Meyer MM, Smith SM (2007) N-Acetylcysteine for patients with prolonged hypotension as prophylaxis for acute renal failure (NEPHRON). Crit Care Med 35:435–441PubMedCrossRefGoogle Scholar
  244. 244.
    Sisillo E, Ceriani R, Bortone F, Juliano G, Salvi L, Veglia F, Fiorentini C, Marenzi G (2008) N-Acetylcysteine for prevention of acute renal failure in patients with chronic renal insufficiency undergoing cardiac surgery: a prospective, randomized, clinical trial. Crit Care Med 36:81–86PubMedCrossRefGoogle Scholar
  245. 245.
    Adabag AS, Ishani A, Koneswaran S, Johnson DJ, Kelly RF, Ward HB, McFalls EO, Bloomfield HE, Chandrashekhar Y (2008) Utility of N-acetylcysteine to prevent acute kidney injury after cardiac surgery: a randomized controlled trial. Am Heart J 155:1143–1149PubMedCrossRefGoogle Scholar
  246. 246.
    Wijeysundera DN, Beattie WS, Rao V, Granton JT, Chan CT (2007) N-Acetylcysteine for preventing acute kidney injury in cardiac surgery patients with pre-existing moderate renal insufficiency. Can J Anaesth 54:872–881PubMedCrossRefGoogle Scholar
  247. 247.
    Sandilands EA, Bateman DN (2009) Adverse reactions associated with acetylcysteine. Clin Toxicol (Phila) 47:81–88Google Scholar
  248. 248.
    Molnar Z, Shearer E, Lowe D (1999) N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study. Crit Care Med 27:1100–1104PubMedCrossRefGoogle Scholar
  249. 249.
    Peake SL, Moran JL, Leppard PI (1996) N-Acetyl-l-cysteine depresses cardiac performance in patients with septic shock. Crit Care Med 24:1302–1310PubMedCrossRefGoogle Scholar
  250. 250.
    Spargias K, Alexopoulos E, Kyrzopoulos S, Iokovis P, Greenwood DC, Manginas A, Voudris V, Pavlides G, Buller CE, Kremastinos D, Cokkinos DV (2004) Ascorbic acid prevents contrast-mediated nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. Circulation 110:2837–2842PubMedCrossRefGoogle Scholar
  251. 251.
    Boscheri A, Weinbrenner C, Botzek B, Reynen K, Kuhlisch E, Strasser RH (2007) Failure of ascorbic acid to prevent contrast-media induced nephropathy in patients with renal dysfunction. Clin Nephrol 68:279–286PubMedGoogle Scholar
  252. 252.
    Wijnen MH, Vader HL, Van Den Wall Bake AW, Roumen RM (2002) Can renal dysfunction after infra-renal aortic aneurysm repair be modified by multi-antioxidant supplementation? J Cardiovasc Surg (Torino) 43:483–488Google Scholar
  253. 253.
    Angstwurm MW, Schottdorf J, Schopohl J, Gaertner R (1999) Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome. Crit Care Med 27:1807–1813PubMedCrossRefGoogle Scholar
  254. 254.
    Angstwurm MW, Engelmann L, Zimmermann T, Lehmann C, Spes CH, Abel P, Strauss R, Meier-Hellmann A, Insel R, Radke J, Schuttler J, Gartner R (2007) Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med 35:118–126PubMedCrossRefGoogle Scholar
  255. 255.
    Reade MC, Fink MP (2005) Bench-to-bedside review: amelioration of acute renal impairment using ethyl pyruvate. Crit Care 9:556–560PubMedCrossRefGoogle Scholar
  256. 256.
    Mishra V, Baines M, Perry SE, McLaughlin PJ, Carson J, Wenstone R, Shenkin A (2007) Effect of selenium supplementation on biochemical markers and outcome in critically ill patients. Clin Nutr 26:41–50PubMedCrossRefGoogle Scholar
  257. 257.
    Schindler R, Stahl C, Venz S, Ludat K, Krause W, Frei U (2001) Removal of contrast media by different extracorporeal treatments. Nephrol Dial Transplant 16:1471–1474PubMedCrossRefGoogle Scholar
  258. 258.
    Lee PT, Chou KJ, Liu CP, Mar GY, Chen CL, Hsu CY, Fang HC, Chung HM (2007) Renal protection for coronary angiography in advanced renal failure patients by prophylactic hemodialysis. A randomized controlled trial. J Am Coll Cardiol 50:1015–1020PubMedCrossRefGoogle Scholar
  259. 259.
    Frank H, Werner D, Lorusso V, Klinghammer L, Daniel WG, Kunzendorf U, Ludwig J (2003) Simultaneous hemodialysis during coronary angiography fails to prevent radiocontrast-induced nephropathy in chronic renal failure. Clin Nephrol 60:176–182PubMedGoogle Scholar
  260. 260.
    Gabutti L, Marone C, Monti M, Malfanti M, Zwahlen U, Pasotti E, Colucci G, Schonholzer C (2003) Does continuous venovenous hemodiafiltration concomitant with radiological procedures provide a significant and safe removal of the iodinated contrast ioversol? Blood Purif 21:152–157PubMedCrossRefGoogle Scholar
  261. 261.
    Huber W, Jeschke B, Kreymann B, Hennig M, Page M, Salmhofer H, Eckel F, Schmidt U, Umgelter A, Schweigart U, Classen M (2002) Haemodialysis for the prevention of contrast-induced nephropathy: outcome of 31 patients with severely impaired renal function, comparison with patients at similar risk and review. Invest Radiol 37:471–481PubMedCrossRefGoogle Scholar
  262. 262.
    Marenzi G, Marana I, Lauri G, Assanelli E, Grazi M, Campodonico J, Trabattoni D, Fabbiocchi F, Montorsi P, Bartorelli AL (2003) The prevention of radiocontrast-agent-induced nephropathy by hemofiltration. N Engl J Med 349:1333–1340PubMedCrossRefGoogle Scholar
  263. 263.
    Marenzi G, Lauri G, Campodonico J, Marana I, Assanelli E, De MM, Grazi M, Veglia F, Fabbiocchi F, Montorsi P, Bartorelli AL (2006) Comparison of two hemofiltration protocols for prevention of contrast-induced nephropathy in high-risk patients. Am J Med 119:155–162PubMedCrossRefGoogle Scholar
  264. 264.
    Reinecke H, Fobker M, Wellmann J, Becke B, Fleiter J, Heitmeyer C, Breithardt G, Hense HW, Schaefer RM (2007) A randomized controlled trial comparing hydration therapy to additional hemodialysis or N-acetylcysteine for the prevention of contrast medium-induced nephropathy: the Dialysis-versus-Diuresis (DVD) Trial. Clin Res Cardiol 96:130–139PubMedCrossRefGoogle Scholar
  265. 265.
    Cruz DN, Perazella MA, Bellomo R, Corradi V, de CM, Kuang D, Ocampo C, Nalesso F, Ronco C (2006) Extracorporeal blood purification therapies for prevention of radiocontrast-induced nephropathy: a systematic review. Am J Kidney Dis 48:361–371Google Scholar
  266. 266.
    Naka T, Jones D, Baldwin I, Fealy N, Bates S, Goehl H, Morgera S, Neumayer HH, Bellomo R (2005) Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report. Crit Care 9:R90–R95PubMedCrossRefGoogle Scholar
  267. 267.
    Amyot SL, Leblanc M, Thibeault Y, Geadah D, Cardinal J (1999) Myoglobin clearance and removal during continuous venovenous hemofiltration. Intensive Care Med 25:1169–1172PubMedCrossRefGoogle Scholar
  268. 268.
    Schenk MR, Beck DH, Nolte M, Kox WJ (2001) Continuous veno-venous hemofiltration for the immediate management of massive rhabdomyolysis after fulminant malignant hyperthermia in a bodybuilder. Anesthesiology 94:1139–1141PubMedCrossRefGoogle Scholar
  269. 269.
    Shigemoto T, Rinka H, Matsuo Y, Kaji A, Tsukioka K, Ukai T, Shimaoka H (1997) Blood purification for crush syndrome. Ren Fail 19:711–719PubMedCrossRefGoogle Scholar
  270. 270.
    Heney D, Essex-Cater A, Brocklebank JT, Bailey CC, Lewis IJ (1990) Continuous arteriovenous haemofiltration in the treatment of tumour lysis syndrome. Pediatr Nephrol 4:245–247PubMedCrossRefGoogle Scholar
  271. 271.
    Meier M, Nitschke M, Perras B, Steinhoff J (2005) Ethylene glycol intoxication and xylitol infusion—metabolic steps of oxalate-induced acute renal failure. Clin Nephrol 63:225–228PubMedGoogle Scholar
  272. 272.
    Moreau CL, Kerns W, Tomaszewski CA, McMartin KE, Rose SR, Ford MD, Brent J (1998) Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META Study Group. J Toxicol Clin Toxicol 36:659–666PubMedCrossRefGoogle Scholar
  273. 273.
    Saccente SL, Kohaut EC, Berkow RL (1995) Prevention of tumor lysis syndrome using continuous veno-venous hemofiltration. Pediatr Nephrol 9:569–573PubMedCrossRefGoogle Scholar
  274. 274.
    Bolcal C, Akay HT, Bingol H, Doganci S, Yildirim V, Yenicesu M, Demirkilic U, Tatar H (2007) Leukodepletion improves renal function in patients with renal dysfunction undergoing on-pump coronary bypass surgery: a prospective randomized study. Thorac Cardiovasc Surg 55:89–93PubMedCrossRefGoogle Scholar
  275. 275.
    Tang AT, Alexiou C, Hsu J, Sheppard SV, Haw MP, Ohri SK (2002) Leukodepletion reduces renal injury in coronary revascularization: a prospective randomized study. Ann Thorac Surg 74:372–377PubMedCrossRefGoogle Scholar
  276. 276.
    Treacher DF, Sabbato M, Brown KA, Gant V (2001) The effects of leucodepletion in patients who develop the systemic inflammatory response syndrome following cardiopulmonary bypass. Perfusion 16(Suppl):67–73PubMedCrossRefGoogle Scholar
  277. 277.
    Salamonsen RF, Anderson J, Anderson M, Bailey M, Magrin G, Rosenfeldt F (2005) Total leukocyte control for elective coronary bypass surgery does not improve short-term outcome. Ann Thorac Surg 79:2032–2038PubMedCrossRefGoogle Scholar
  278. 278.
    Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8:R204–R212PubMedCrossRefGoogle Scholar

Copyright information

© Copyright jointly hold by Springer and ESICM 2009

Authors and Affiliations

  • Michael Joannidis
    • 1
  • Wilfred Druml
    • 2
  • Lui G. Forni
    • 3
  • A. B. Johan Groeneveld
    • 4
  • Patrick Honore
    • 5
  • Heleen M. Oudemans-van Straaten
    • 6
  • Claudio Ronco
    • 7
  • Marie R. C. Schetz
    • 8
  • Arend Jan Woittiez
    • 9
  1. 1.Medical Intensive Care Unit, Department of Internal Medicine IMedical University InnsbruckInnsbruckAustria
  2. 2.Department of Internal Medicine IIIUniversity Hospital ViennaViennaAustria
  3. 3.Western Sussex Hospitals Trust, Brighton and Sussex Medical School, University of Sussex BrightonUK
  4. 4.Department of Intensive CareVU Medical CenterAmsterdamThe Netherlands
  5. 5.Department of Intensive Care, Burn CenterQueen Astrid Military HospitalNeder-Over-Heembeek (Brussels)Belgium
  6. 6.Department of Intensive Care MedicineOnze Lieve Vrouwe GasthuisAmsterdamThe Netherlands
  7. 7.Department of Nephrology Dialysis and TransplantationSan Bortolo HospitalVicenzaItaly
  8. 8.Department of Intensive Care MedicineUniversity Hospital, Catholic University LeuvenLeuvenBelgium
  9. 9.Division of Nephrology, Department of MedicineUniversity Medical Center Groningen, University of GroningenGroningenThe Netherlands

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