The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study
- 5.8k Downloads
The objective of this study was to examine the relationship between the amount of energy and protein administered and clinical outcomes, and the extent to which pre-morbid nutritional status influenced this relationship.
We conducted an observational cohort study of nutrition practices in 167 intensive care units (ICUs) across 37 countries. Patient demographics were collected, and the type and amount of nutrition received were recorded daily for a maximum of 12 days. Patients were followed prospectively to determine 60-day mortality and ventilator-free days (VFDs). We used body mass index (BMI, kg/m2) as a marker of nutritional status prior to ICU admission. Regression models were developed to evaluate the relationship between nutrition received and 60-day mortality and VFDs, and to examine how BMI modifies this relationship.
Data were collected on 2,772 mechanically ventilated patients who received an average of 1,034 kcal/day and 47 g protein/day. An increase of 1,000 cal per day was associated with reduced mortality [odds ratio for 60-day mortality 0.76; 95% confidence intervals (CI) 0.61–0.95, p = 0.014] and an increased number of VFDs (3.5 VFD, 95% CI 1.2–5.9, p = 0.003). The effect of increased calories associated with lower mortality was observed in patients with a BMI <25 and ≥35 with no benefit for patients with a BMI 25 to <35. Similar results were observed when comparing increasing protein intake and its effect on mortality.
Increased intakes of energy and protein appear to be associated with improved clinical outcomes in critically ill patients, particularly when BMI is <25 or ≥35.
KeywordsCritical care Nutrition therapy Nutritional status Body mass index
We are grateful to the scores of participants across the world that collected data for this study, to Xuran Jiang who assisted with the data analysis, and to Drs. John Drover, Andrew Davies, and Renee Stapleton for their assistance in reviewing the manuscript.
- 6.The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group (1991) Perioperative total parenteral nutrition in surgical patients. N Engl J Med 325:525–532Google Scholar
- 9.World Health Organization. Available at: http://www.who.int/bmi/index.jsp?introPage=intro_3.htmp
- 10.Demidenko E (2004) Mixed models: theory and applications. Wiley, New JerseyGoogle Scholar
- 11.SAS Institute Inc. (2005) The GLIMMIX Procedure. SAS/STAT User’s Guide, Version 9.1.3 Cary, NCGoogle Scholar
- 12.Harrell FE (2001) Regression modeling strategies: with application to linear models, logistic regression and survival analysis. Springer, New YorkGoogle Scholar
- 13.SAS Institute Inc (1999) The MIXED Procedure. SAS/STAT User’s Guide, vol 8. SAS Institute Inc, Cary, pp 2083–2226Google Scholar
- 20.Heimburger DC (2006) Adulthood in modern nutrition. In: Shike M, Ross AC, Caballero B, Cousins RJ (eds) Health and disease, vol 53. Lippincott Williams &Wilkins, New York, pp 830–842Google Scholar
- 24.Heyland DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P, for the Canadian Critical Care Clinical Practice Guidelines Committee (2003) The Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. J Parenter Enteral Nutr 5:355–373CrossRefGoogle Scholar