Acute respiratory failure in intensive care units. FINNALI: a prospective cohort study
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To evaluate the incidence, treatment and mortality of acute respiratory failure (ARF) in Finnish intensive care units (ICUs).
Prospective multicentre cohort study.
All adult patients in 25 ICUs were screened for use of invasive or non-invasive ventilatory support during an 8-week period. Patients needing ventilatory support for more than 6 h were included and defined as ARF patients. Risk factors for ARF and details of prior chronic health status were assessed. Ventilatory and concomitant treatments were evaluated and recorded daily throughout the ICU stay. ICU and 90-day mortalities were assessed.
A total of 958 (39%) from the 2,473 admitted patients were treated with ventilatory support for more than 6 h. Incidence of ARF, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) was 149.5, 10.6 and 5.0/100,000 per year, respectively. Ventilatory support was started with non-invasive interfaces in 183 of 958 (19%) patients. Ventilatory modes allowing triggering of spontaneous breaths were preferred (81%). Median tidal volume/predicted body weight was 8.7 (7.6–9.9) ml/kg and plateau pressure 19 (16–23) cmH2O. The 90-day mortality of ARF was 31%.
While the incidence of ARF requiring ventilatory support is higher, the incidence of ALI and ARDS seems to be lower in Finland than previously reported in other countries. Tidal volumes are higher than recommended in the concept of lung protective strategy. However, restriction of peak airway pressure was used in the majority of ARF patients.
KeywordsAcute respiratory failure Acute lung injury Acute respiratory distress syndrome Mechanical ventilation Outcome
We thank the principal study nurse Raija Niemi and all investigators and study nurses of the FINNALI study in the participating hospitals. The study was supported by an EVO grant from Helsinki University Hospital (TYH7250), Instrumentarium Scientific Foundation, external funding for Critical Care Medicine Research Group in Tampere, Health Care Foundation of North Finland and EVO grants from North Karelia, South Savo and Satakunta Central Hospitals.
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