The FINNALI study on acute respiratory failure: not the final cut
- First Online:
- Cite this article as:
- Estenssoro, E. Intensive Care Med (2009) 35: 1328. doi:10.1007/s00134-009-1518-0
- 394 Downloads
The authors of the FINNALI study, published in this issue of Intensive Care Medicine , are to be congratulated for a huge task: to describe the incidence and other epidemiological features of acute respiratory failure (ARF) in a whole country, Finland. As ARF is a frequent cause of admission to the ICU, it is surprising how few studies aim at characterising it [2, 3, 4, 5]. Researchers have mainly focussed on the most severe forms of ARF: acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) .
Some points deserve special comment: First, the incidence of 149.5 cases per 100,000/year is much higher than the 88.6 and 77.6 previously reported in prospective, population-based studies [2, 4]. This might be due to dissimilar definitions: the FINNALI investigators used a somehow “loose” definition of ARF: the need for ventilatory support with intubation, or the use of positive airway pressure for more than 6 h. Instead, Lewandowski et al.  and Luhr et al.  defined ARF as the need for intubation and mechanical ventilation for more than 24 h. This last study, like the present FINNALI, also included patients with noninvasive ventilatory support. Behrendt et al., in the retrospective analysis of a large and representative US administrative database, found 137 cases per 100,000/year. Comparisons, again, are not easy, since they used ICD-9-CM codes for definition, plus continuous ventilatory support ≥24 h. Interestingly, this study includes cases of ARF not restricted to the ICU. In real life, many ARF patients requiring ventilatory support might be treated in the ED and in general wards.
Even when the FINNALI investigators corrected their numbers for 24 h, which yielded an incidence of 102.7 per 100,000/year, their figures seem to be high. Their main risk factor for ARF was postoperative state, similar to the International Study on Mechanical Ventilation , but doubling the frequency (41.3 vs. 20.8%, respectively), contrasting with pneumonia as the main cause of ARF in the rest of the series [2, 4]. Prolonged duration of anaesthesia cannot be discarded as a cause of ARF in the FINNALI cohort. This is relevant, because in this era of rationing, these less severely affected patients might be admitted to intermediate-care units and not to the more complex and resource-consuming ICUs.
In epidemiological studies, seasonality should be taken into account. This study was performed in spring. It is usually held that airway and lung disease are more frequent in winter, and given that pneumonia is the most frequent clinical entity causing ARDS, the incidence might have been underestimated. There are some data, however, showing no differences in ARDS occurrence across different months .
What about ALI and ARDS, the most severe forms of ARF? Incidence was low: 10.6/5 cases of ALI/ARDS per 100,000/year compared to 18/13.5 in three Scandinavian countries , to 34/28, respectively, in three Australian states , or to 79/59 in King County, USA . The authors wonder about a diminished, yet not demonstrated , genetic propensity for ALI in Finland. Furthermore, a decreased exposure to some risk factor might play a role: for example, trauma was a risk factor in only 1.5% of ALI/ARDS, probably due to organisational characteristics of Finnish society. However, some chance of misclassification, and so of a difference in incidences, cannot be discarded: the median PaO2/FIO2 of the non-ALI/ARDS group is ≤300 [272 (189–352)].
With respect to outcomes, two points are interesting: first, the choice of 90-day mortality as the main outcome measure, in line with adopting novel outcome variables for critical care; second, the report of previous health state by means of the ADL scale. Ninety-day mortality for ARF was 31%, lying within the 31–42% reported in the literature [2, 3, 4, 5, 7]; as many as 48.4% of patients had some disability on admission. The figure of 47% mortality for ALI/ARDS falls within the expected 39–60% of epidemiological studies [4, 7, 10, 12, 13]. Once more, severity of illness on admission according to SAPS II, chronic heart disease, suspected aspiration and baseline PaO2/FIO2 were independently associated with a worse outcome. These factors have been repeatedly found [12, 14]. Of note, this is another study demonstrating that the subset of patients with the worst PaO2/FIO2 values displays the highest mortality [4, 15, 16]. Perhaps future definitions of ALI/ARDS will have to consider this special population.
Another interesting point lies in the use of tidal volumes. Notwithstanding that this study was undertaken many years after the publication of the ARMA study , tidal volumes used were 7.4 ml/kg actual body weight (ABW) and indeed of 8.7 ml/kg of predicted body weight (PBW). These numbers are certainly higher than the 6.2 ml/kg of PBW that demonstrated a survival benefit . Moreover, and not surprisingly, the difference between ABW and PBW weight was larger in women, who were thus ventilated with 9.6 ml/kg PBW.
Two reflections arise from these findings that cast doubt on the efficacy of translating research into clinical practice : First, why didn't these high tidal volumes impact mortality? A possible reason might be that patients in the FINNALI study were not severely compromised: though non-ALI/ARDS and ALI/ARDS groups showed a decrease in oxygenation (mean PaO2/FIO2 272 and 200, respectively), their mean plateau pressures were in fact low: 19 and 23 cmH2O, respectively. Hager et al.  have shown that the survival benefit of diminishing plateau pressure is clear and statistically significant only in the quartile of highest plateau pressures.
Finally, is the calculation of PBW systematically performed in real practice? The findings of this study raise concerns about this relevant issue, given that higher than physiological tidal volumes have been associated with the development of ARDS in patients on mechanical ventilation for causes other than ARDS .
To conclude, this study, together with the others mentioned, contributes to the overall picture of ARF around the world. But the face of ARF will probably keep on changing in incidence, in risk factors, in outcomes or in all together. There will never be a final cut. The forthcoming pandemic of swine flu is one example of how dynamic future scenarios might develop.