Depression in general intensive care unit survivors: a systematic review
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To critically review data on the prevalence of depressive symptoms in general intensive care unit (ICU) survivors, risk factors for these symptoms, and their impact on health-related quality of life (HRQOL).
We conducted a systematic review using Medline, EMBASE, Cochrane Library, CINAHL, PsycINFO, and a hand-search of 13 journals.
Fourteen studies were eligible. The median point prevalence of “clinically significant” depressive symptoms was 28% (total n = 1,213). Neither sex nor age were consistent risk factors for post-ICU depression, and severity of illness at ICU admission was consistently not a risk factor. Early post-ICU depressive symptoms were a strong risk factor for subsequent depressive symptoms. Post-ICU depressive symptoms were associated with substantially lower HRQOL.
Depressive symptoms are common in general ICU survivors and negatively impact HRQOL. Future studies should address how factors related to individual patients, critical illness and post-ICU recovery are associated with depression in ICU survivors.
KeywordsDepression Critical care Risk factors Quality of life Outcome assessment (health care)
Intensive care unit
The authors thank R.N. Martin Boyle and R.N. Christina Jones, Ph.D., for providing additional data from their studies included in this review. Dr. Needham is supported by a Clinician-Scientist Award from the Canadian Institutes of Health Research and by the National Institutes of Health (Acute Lung Injury SCCOR Grant # P050 HL73994). Dr. Bienvenu is supported by a Career Development Award from the National Institutes of Health (K23 MH64543). The funding bodies had no role in the study design, manuscript writing or decision to submit the manuscript for publication.
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