Intensive Care Medicine

, Volume 35, Issue 1, pp 30–44 | Cite as

Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia

  • Massimo AntonelliEmail author
  • Elie Azoulay
  • Marc Bonten
  • Jean Chastre
  • Giuseppe Citerio
  • Giorgio Conti
  • Daniel De Backer
  • François Lemaire
  • Herwig Gerlach
  • Johan Groeneveld
  • Goran Hedenstierna
  • Duncan Macrae
  • Jordi Mancebo
  • Salvatore M. Maggiore
  • Alexandre Mebazaa
  • Philipp Metnitz
  • Jerôme Pugin
  • Jan Wernerman
  • Haibo Zhang
Year in Review 2008

Traumatic brain injury

Recent experimental evidence suggests that matrix metalloproteinases (MMPs) are implicated in the pathophysiology of traumatic brain injury (TBI) by increasing blood–brain barrier permeability and exacerbating post-traumatic edema. MMPs are zinc-dependent and cell surface-associated endopeptidases that cleave all extracellular matrix (ECM) components, including collagen, laminin, and proteoglycans. The MMPs and their potential deleterious effects are tightly regulated at transcriptional and post-transcriptional levels through proform activation and by MMP tissue inhibitors (TIMPs) Two members of this family have a very specific and marked activity against gelatin and are termed gelatinases. In vitro studies have demonstrated that the secretion of gelatinases is significantly increased in cortical cultures when mechanical injury is simulated. In human TBI, data about the presence of gelatinases in the brain extracellular fluid (ECF) and their temporal profile,...


Traumatic Brain Injury Severe Sepsis Renal Replacement Therapy Status Epilepticus Systemic Inflammatory Response Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Massimo Antonelli
    • 1
    Email author
  • Elie Azoulay
    • 2
  • Marc Bonten
    • 3
  • Jean Chastre
    • 4
  • Giuseppe Citerio
    • 5
  • Giorgio Conti
    • 1
  • Daniel De Backer
    • 6
  • François Lemaire
    • 7
  • Herwig Gerlach
    • 8
  • Johan Groeneveld
    • 9
  • Goran Hedenstierna
    • 10
  • Duncan Macrae
    • 11
  • Jordi Mancebo
    • 12
  • Salvatore M. Maggiore
    • 1
  • Alexandre Mebazaa
    • 13
  • Philipp Metnitz
    • 14
  • Jerôme Pugin
    • 15
  • Jan Wernerman
    • 16
  • Haibo Zhang
    • 17
  1. 1.Department of Intensive Care and Anesthesiology, Policlinico Universitario A. GemelliUniversità Cattolica del Sacro CuoreRomeItaly
  2. 2.Intensive Care Medicine UnitSaint Louis HospitalParisFrance
  3. 3.Department of Medical Microbiology Julius Center for Health Sciences and Primary CareUniversity Medical CenterUtrechtThe Netherlands
  4. 4.Reanimation MedicaleHopital Pitié SalpétrièreParisFrance
  5. 5.Neurointensive Care UnitOspedale S. GerardoMonzaItaly
  6. 6.Service des Soins IntensifsErasme HospitalBrusselsBelgium
  7. 7.Intensive Care UnitHenri Mondor HospitalCreteilFrance
  8. 8.Department of AnesthesiologyVivantes-Klinikum NeukoellnBerlinGermany
  9. 9.Intensive Care Medicine UnitVUMCAmsterdamThe Netherlands
  10. 10.Department of Clinical PhysiologyUppsala UniversityUppsalaSweden
  11. 11.Pediatric Intensive Care UnitRoyal Brompton HospitalLondonUK
  12. 12.Intensive Care Medicine UnitHospital Sant PauBarcelonaSpain
  13. 13.Department of Anesthesiology and Critical Care MedicineLariboisière HospitalParisFrance
  14. 14.Department of Anesthesia and General Intensive Care MedicineUniversity Hospital of ViennaViennaAustria
  15. 15.Intensive Care Medicine UnitUniversity Hospital of GenevaGenevaSwitzerland
  16. 16.Departments of Anesthesiology and Intensive Care MedicineKarolinska University HospitalStockholmSweden
  17. 17.Interdepartmental Division of Critical Care MedicineUniversity of TorontoTorontoCanada

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