Intensive Care Medicine

, 35:123 | Cite as

Intensive insulin therapy: enhanced Model Predictive Control algorithm versus standard care

  • Jeremy J. CordingleyEmail author
  • Dirk Vlasselaers
  • Natalie C. Dormand
  • Pieter J. Wouters
  • Stephen D. Squire
  • Ludovic J. Chassin
  • Malgorzata E. Wilinska
  • Clifford J. Morgan
  • Roman Hovorka
  • Greet Van den Berghe



To investigate the effectiveness of an enhanced software Model Predictive Control (eMPC) algorithm for intravenous insulin infusion, targeted at tight glucose control in critically ill patients, over 72 h, in two intensive care units with different management protocols.


Comparison with standard care in a two center open randomized clinical trial.


Two adult intensive care units in University Hospitals.

Patients and participants

Thirty-four critically ill patients with hyperglycaemia (glucose >120 mg/dL) or already receiving insulin infusion.


Patients were randomized, within each ICU, to intravenous insulin infusion advised by eMPC algorithm or the ICU’s standard insulin infusion administration regimen.

Measurements and results

Arterial glucose concentration was measured at study entry and when advised by eMPC or measured as part of standard care. Time-weighted average glucose concentrations in patients receiving eMPC advised insulin infusions were similar [104 mg/dL (5.8 mmol/L)] in both ICUs. eMPC advised glucose measurement interval was significantly different between ICUs (1.1 vs. 1.8 h, P < 0.01). The standard care insulin algorithms resulted in significantly different time-weighted average glucose concentrations between ICUs [128 vs. 99 mg/dL (7.1 vs. 5.5 mmol/L), P < 0.01].


In this feasibility study the eMPC algorithm provided similar, effective and safe tight glucose control over 72 h in critically ill patients in two different ICUs. Further development is required to reduce glucose sampling interval while maintaining a low risk of hypoglycaemia.


Hyperglycaemia Glucose Critical care Insulin Model Predictive Control Algorithm 



The authors wish to thank the patients, nurses, doctors, clinical engineers and allied health professionals in both ICUs for their support in undertaking this study. The CLINICIP project is supported by an EC 6th Framework Programme grant.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Jeremy J. Cordingley
    • 1
    Email author
  • Dirk Vlasselaers
    • 2
  • Natalie C. Dormand
    • 1
  • Pieter J. Wouters
    • 2
  • Stephen D. Squire
    • 1
  • Ludovic J. Chassin
    • 3
  • Malgorzata E. Wilinska
    • 3
  • Clifford J. Morgan
    • 1
  • Roman Hovorka
    • 3
  • Greet Van den Berghe
    • 2
  1. 1.Adult Intensive Care UnitRoyal Brompton HospitalLondonUK
  2. 2.Intensive Care UnitUniversity HospitalLeuvenBelgium
  3. 3.Department of PaediatricsUniversity of CambridgeCambridgeUK

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