Intensive Care Medicine

, 34:1718

Comparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizers

  • Fabio Ferrari
  • Zhi-Hai Liu
  • Qin Lu
  • Marie-Helene Becquemin
  • Kamel Louchahi
  • Guy Aymard
  • Charles-Hugo Marquette
  • Jean-Jacques Rouby
Experimental

Abstract

Objective

To compare the efficiency of an Aeroneb Pro vibrating plate and an Atomisor MegaHertz ultrasonic nebulizer for providing ceftazidime distal lung deposition.

Design

In vitro experiments. One gram of cetazidime was nebulized in respiratory circuits and mass median aerodynamic diameter of particles generated by ultrasonic and vibrating plate nebulizers was compared using a laser velocimeter. In vivo experiments. Lung tissue concentrations and extrapulmonary depositions were measured in ten anesthetized ventilated piglets with healthy lungs that received 1 g of ceftazidime by nebulization with either an ultrasonic (n = 5), or a vibrating plate (n = 5) nebulizer.

Setting

A two-bed Experimental Intensive Care Unit of a University School of Medicine.

Intervention

Following sacrifice, 5 subpleural specimens were sampled in dependent and nondependent lung regions for measuring ceftazidime lung tissue concentrations by high-performance liquid chromatography.

Measurements and results

Mass median aerodynamic diameters generated by both nebulizers were similar with more than 95% of the particles between 0.5 and 5 μm. Lung tissue concentrations were 553 ± 123 [95% confidence interval: 514–638] μg g−1 using ultrasonic nebulizer, and 452 ± 172 [95% confidence interval: 376–528] μg g−1 using vibrating plate nebulizers (NS). Extrapulmonary depositions were, respectively, of 38 ± 5% (ultrasonic) and 34 ± 4% (vibrating plate) (NS).

Conclusions

Vibrating plate nebulizer is comparable to ultrasonic nebulizers for ceftazidime nebulization. It may represent a new attractive technology for inhaled antibiotic therapy.

Keywords

Ultrasonic Vibrating plate Nebulizer Nebulization of antibiotics Lung tissue concentration 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Fabio Ferrari
    • 1
  • Zhi-Hai Liu
    • 2
  • Qin Lu
    • 3
    • 8
  • Marie-Helene Becquemin
    • 4
  • Kamel Louchahi
    • 5
  • Guy Aymard
    • 6
  • Charles-Hugo Marquette
    • 7
  • Jean-Jacques Rouby
    • 3
  1. 1.Department of AnesthesiologyFaculdade de Medicina da Universidade Estadual Paulista Julio de Mesquita FilhoBotucatuBrazil
  2. 2.Department of Emergency Medicine, School of MedicineSecond Affiliated Hospital, Zhejiang UniversityHangzhouChina
  3. 3.Surgical Intensive Care Unit Pierre Viars, Department of Anesthesiology and Critical Care MedicineAssistance Publique–Hôpitaux de Paris, La Pitié-Salpêtrière Hospital, University of Paris-6ParisFrance
  4. 4.Department of Respiratory PhysiologyAssistance Publique–Hôpitaux de Paris, La Pitié-Salpêtrière Hospital, Denis Diderot UniversityParisFrance
  5. 5.Department of PharmacologyAssistance Publique-Hôpitaux de Paris, Avicenne HospitalBobignyFrance
  6. 6.Department of PharmacologyAssistance Publique–Hôpitaux de Paris, La Pitié-Salpêtrière HospitalParisFrance
  7. 7.Département Hospitalo-Universitaire de Recherche Expérimentale and INSERM U 416 of Institut PasteurUniversirty of LilleLilleFrance
  8. 8.Réanimation Chirurgicale Polyvalente Pierre Viars, Department of Anesthesiology and Critical CareLa Pitié-Salpêtrière HospitalParisFrance

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