Intensive Care Medicine

, Volume 34, Issue 8, pp 1434–1440 | Cite as

Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia

  • Charles-Edouard Luyt
  • Alain Combes
  • Catherine Reynaud
  • Guillaume Hekimian
  • Ania Nieszkowska
  • Marc Tonnellier
  • Alexandra Aubry
  • Jean-Louis Trouillet
  • Maguy Bernard
  • Jean Chastre



To assess the predictive capacity for the diagnosis of ventilator-associated pneumonia (VAP) of serum procalcitonin levels before and on the day it is suspected.

Design and setting

Single-center observational study in the intensive care unit of a teaching hospital.

Patients and participants

Consecutive patients whose serum procalcitonin levels were available on the day that VAP was clinically suspected (day 1) and at some time within the preceding 5 days (“before”).

Measurements and results

Serum procalcitonin levels were determined on day 1 and “before”. Among the 73 suspected episodes VAP was confirmed by quantitative bronchoalveolar lavage cultures in 32 and refuted in 41. Respective median “before” procalcitonin levels were 1.89 ng/ml (interquartile range 0.18–6.01) and 2.14 (0.76–5.75) in patients with and without VAP, but their respective median day-1 procalcitonin levels did not differ: 1.07 ng/ml (0.39–6.57) vs. 1.40 (0.67–3.39). On day 1 a 0.5 ng/ml procalcitonin threshold had 72% sensitivity but only 24% specificity for diagnosing VAP. Between “before” and day 1, procalcitonin increased in 41% and 15% of patients with and without VAP, respectively. Thus a procalcitonin rise on day 1, compared to its “before” level, had 41% sensitivity and 85% specificity for diagnosing VAP, with respective positive and negative predictive values of 68% and 65%.


Crude values and procalcitonin rise had poor diagnostic value for VAP in this particular setting and thus should not be used to initiate antibiotics when VAP is clinically suspected.


Ventilator-associated pneumonia Procalcitonin Diagnosis Clinical pulmonary infection score 

Supplementary material

134_2008_1112_MOESM1_ESM.doc (28 kb)
Electronic Supplementary Material (DOC 28K)


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Charles-Edouard Luyt
    • 1
  • Alain Combes
    • 1
  • Catherine Reynaud
    • 1
  • Guillaume Hekimian
    • 1
  • Ania Nieszkowska
    • 1
  • Marc Tonnellier
    • 1
  • Alexandra Aubry
    • 2
  • Jean-Louis Trouillet
    • 1
  • Maguy Bernard
    • 3
  • Jean Chastre
    • 1
  1. 1.Service de Réanimation Médicale, Groupe Hospitalier Pitié Salpêtrière, AP-HPUniversité Paris 6, Pierre-et-Marie-CurieParis Cedex 13France
  2. 2.Service de Bactériologie, Groupe Hospitalier Pitié Salpêtrière, AP-HPUniversité Paris 6, Pierre-et-Marie-CurieParis Cedex 13France
  3. 3.Service de Biochimie, Groupe Hospitalier Pitié Salpêtrière, AP-HPUniversité Paris 6, Pierre-et-Marie-CurieParis Cedex 13France

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