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Intensive Care Medicine

, Volume 34, Issue 4, pp 598–609 | Cite as

Year in review in Intensive Care Medicine, 2007. III. Ethics and legislation, health services research, pharmacology and toxicology, nutrition and paediatrics

  • Massimo AntonelliEmail author
  • Elie Azoulay
  • Marc Bonten
  • Jean Chastre
  • Giuseppe Citerio
  • Giorgio Conti
  • Daniel De Backer
  • François Lemaire
  • Herwig Gerlach
  • Johan Groeneveld
  • Goran Hedenstierna
  • Duncan Macrae
  • Jordi Mancebo
  • Salvatore M. Maggiore
  • Alexandre Mebazaa
  • Philipp Metnitz
  • Jerôme Pugin
  • Jan Wernerman
  • Haibo Zhang
Year in Review 2007

Ethics and legislation

End of life

In July 2006, Intensive Care Medicine (ICM) launched a new series of articles on legislation on end of life in different countries, of course focused on intensive care unit (ICU) settings. The first paper came from India [1]. Then followed papers on the legal situation and actual court cases in Belgium, Germany, Italy, Brazil, Israel, the Netherlands, and the UK [2, 3, 4, 5, 6, 7, 8]. Others are still in the pipeline, namely from Austria and Spain. Looking at the whole series of published articles gives an interesting overview of the current situation in many countries, mostly – though not exclusively – in the Western world, which shows many similarities but also some important differences.

The first common finding is that justice is always at pains to deal with intensive care physicians when they go to court accused of murder or assassination, be it in Italy, Spain, Belgium, Canada, France or in the Netherlands [3, 7, 9, 10, 11, 12]. The respect for...

Keywords

Down Syndrome Hypoplastic Left Heart Syndrome Intensive Care Unit Discharge Relative Adrenal Insufficiency Heated Humidifier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Mani RK (2006) End-of-life care in India. Intensive Care Med 32:1066–1068PubMedCrossRefGoogle Scholar
  2. 2.
    Bell D (2007) The legal framework for end of life care: a United Kingdom perspective. Intensive Care Med 33:158–162PubMedCrossRefGoogle Scholar
  3. 3.
    Kompanje EJ (2006) Care for the dying in intensive care in The Netherlands. Intensive Care Med 32:2067–2069PubMedCrossRefGoogle Scholar
  4. 4.
    Michalsen A (2007) Care for dying patients – German legislation. Intensive Care Med 33:1823–1826PubMedCrossRefGoogle Scholar
  5. 5.
    Soares M, Terzi RG, Piva JP (2007) End-of-life care in Brazil. Intensive Care Med 33:1014–1017PubMedCrossRefGoogle Scholar
  6. 6.
    Steinberg A, Sprung CL (2006) The dying patient: new Israeli legislation. Intensive Care Med 32:1234–1237PubMedCrossRefGoogle Scholar
  7. 7.
    Vincent JL (2006) End-of-life practice in Belgium and the new euthanasia law. Intensive Care Med 32:1908–1911PubMedCrossRefGoogle Scholar
  8. 8.
    Zamperetti N, Proietti R (2006) End of life in the ICU: laws, rules and practices: the situation in Italy. Intensive Care Med 32:1620–1622PubMedCrossRefGoogle Scholar
  9. 9.
    Bock M, Ciarrocchi V, Wiedermann CJ (2007) Case involving end-of-life decision issues in Italy. Intensive Care Med 33:1041–1042PubMedCrossRefGoogle Scholar
  10. 10.
    Del Nogal Saez F (2006) Opiates at the end of life in an emergency department in Spain: euthanasia or good clinical practice? Intensive Care Med 32:1086–1087PubMedCrossRefGoogle Scholar
  11. 11.
    Lemaire FJ (2004) A law for end of life care in France? Intensive Care Med 30:2120PubMedCrossRefGoogle Scholar
  12. 12.
    Rocker G (2003) End of life care in Canada after a murder charge in an ICU. Intensive Care Med 29:2336–2337CrossRefGoogle Scholar
  13. 13.
    Boles JM (2006) End of life in the intensive care unit: from practice to law. What do the lawmakers tell the caregivers? A new series in Intensive Care Medicine. Intensive Care Med 32:955–957PubMedCrossRefGoogle Scholar
  14. 14.
    Michalsen A, Reinhart K (2006) “Euthanasia”: a confusing term, abused under the Nazi regime and misused in present end-of-life debate. Intensive Care Med 32:1304–1310PubMedCrossRefGoogle Scholar
  15. 15.
    Sprung CL, Maia P, Bulow HH, Ricou B, Armaganidis A, Baras M, Wennberg E, Reinhart K, Cohen SL, Fries DR, Nakos G, Thijs LG (2007) The importance of religious affiliation and culture on end-of-life decisions in European intensive care units. Intensive Care Med 33:1732–1739PubMedCrossRefGoogle Scholar
  16. 16.
    Boussarsar M, Bouchoucha S (2006) Dying at home: cultural and religious preferences. Intensive Care Med 32:1917–1918PubMedCrossRefGoogle Scholar
  17. 17.
    Kallel H, Dammak H, Bahloul M, Ben Hamida C, Chelly H, Rekik N, Bouaziz M (2006) A good death: another break in the wall. Intensive Care Med 32:1915–1916PubMedCrossRefGoogle Scholar
  18. 18.
    Zamperetti N, Latronico N (2006) Nutrition and hydration of patients in vegetative state: a statement of the Italian National Committee for Bioethics. Intensive Care Med 32:750–751PubMedCrossRefGoogle Scholar
  19. 19.
    Giannini A, Pinto AM, Rossetti G, Prandi E, Tiziano D, Brahe C, Nardocci N (2006) Respiratory failure in infants due to spinal muscular atrophy with respiratory distress type 1. Intensive Care Med 32:1851–1855PubMedCrossRefGoogle Scholar
  20. 20.
    Ferrand E, Marty J (2006) Prehospital withholding and withdrawal of life-sustaining treatments. The French LATASAMU survey. Intensive Care Med 32:1498–1505PubMedCrossRefGoogle Scholar
  21. 21.
    Rocker G (2006) Life-support limitation in the pre-hospital setting. Intensive Care Med 32:1464–1466PubMedCrossRefGoogle Scholar
  22. 22.
    Lemaire F (2006) The Nuremberg doctors' trial: the 60th anniversary. Intensive Care Med 32:2049–2052PubMedCrossRefGoogle Scholar
  23. 23.
    Coats TJ, Shakur H (2005) Consent in emergency research: new regulations. Emerg Med J 22:683–685PubMedCrossRefGoogle Scholar
  24. 24.
    Harvey SE, Elbourne D, Ashcroft J, Jones CM, Rowan K (2006) Informed consent in clinical trials in critical care: experience from the PAC-Man Study. Intensive Care Med 32:2020–2025PubMedCrossRefGoogle Scholar
  25. 25.
    Ciroldi M, Cariou A, Adrie C, Annane D, Castelain V, Cohen Y, Delahaye A, Joly LM, Galliot R, Garrouste-Orgeas M, Papazian L, Michel F, Barnes NK, Schlemmer B, Pochard F, Azoulay E (2007) Ability of family members to predict patient's consent to critical care research. Intensive Care Med 33:807–813PubMedCrossRefGoogle Scholar
  26. 26.
    Veelo DP, Spronk PE, Kuiper MA, Korevaar JC, van der Voort PH, Schultz MJ (2006) A change in the Dutch Directive on Medical Research Involving Human Subjects strongly increases the number of eligible intensive care patients: an observational study. Intensive Care Med 32:1845–1850PubMedCrossRefGoogle Scholar
  27. 27.
    Jansen TC, Kompanje EJ, Druml C, Menon DK, Wiedermann CJ, Bakker J (2007) Deferred consent in emergency intensive care research: what if the patient dies early? Use the data or not? Intensive Care Med 33:894–900PubMedCrossRefGoogle Scholar
  28. 28.
    Klepstad P, Dale O (2006) Further restrictions for ICU research. Intensive Care Med 32:175PubMedCrossRefGoogle Scholar
  29. 29.
    Klepstad P, Guttormsen AB, Dale O (2007) Common sense won: engagement from experts repealed Norwegian restrictions for ICU research. Intensive Care Med 33:1827–1828PubMedCrossRefGoogle Scholar
  30. 30.
    Hicks LK, Laupacis A, Slutsky AS (2007) A primer on data safety monitoring boards: mission, methods, and controversies. Intensive Care Med 33:1815–1818PubMedCrossRefGoogle Scholar
  31. 31.
    Scales DC, Laupacis A (2007) Health technology assessment in critical care. Intensive Care Med 33:2183–2191PubMedCrossRefGoogle Scholar
  32. 32.
    Weijer C, Miller PB (2007) Evaluating benefits and harms in intensive care research. Intensive Care Med 33:1819–1822PubMedCrossRefGoogle Scholar
  33. 33.
    Graat ME, Kroner A, Spronk PE, Korevaar JC, Stoker J, Vroom MB, Schultz MJ (2007) Elimination of daily routine chest radiographs in a mixed medical–surgical intensive care unit. Intensive Care Med 33:639–644PubMedCrossRefGoogle Scholar
  34. 34.
    Subbe CP, Gao H, Harrison DA (2007) Reproducibility of physiological track-and-trigger warning systems for identifying at-risk patients on the ward. Intensive Care Med 33:619–624PubMedCrossRefGoogle Scholar
  35. 35.
    Ouimet S, Kavanagh BP, Gottfried SB, Skrobik Y (2007) Incidence, risk factors and consequences of ICU delirium. Intensive Care Med 33:66–73PubMedCrossRefGoogle Scholar
  36. 36.
    Jones C, Backman C, Capuzzo M, Flaatten H, Rylander C, Griffiths RD (2007) Precipitants of post-traumatic stress disorder following intensive care: a hypothesis generating study of diversity in care. Intensive Care Med 33:978–985PubMedCrossRefGoogle Scholar
  37. 37.
    Darmon M, Thiery G, Ciroldi M, Porcher R, Schlemmer B, Azoulay E (2007) Should dialysis be offered to cancer patients with acute kidney injury? Intensive Care Med 33:765–772PubMedCrossRefGoogle Scholar
  38. 38.
    Soares M, Salluh JI, Toscano L, Dias FL (2007) Outcomes and prognostic factors in patients with head and neck cancer and severe acute illnesses. Intensive Care Med 33:2009–2013PubMedCrossRefGoogle Scholar
  39. 39.
    Greene SL, Gawarammana I, Wood DM, Jones AL, Dargan PI (2007) Relative safety of hyperinsulinaemia/euglycaemia therapy in the management of calcium channel blocker overdose: a prospective observational study. Intensive Care Med 33:2019–2024PubMedCrossRefGoogle Scholar
  40. 40.
    Bonnet MP, Minville V, Asehnoune K, Bridoux D, Poggi-Bach J, Duranteau J, Benhamou D (2007) Glycine and ammonia plasma concentrations during sedation with remifentanil in critically ill patients. Intensive Care Med 33:1179–1182PubMedCrossRefGoogle Scholar
  41. 41.
    Grenouillet-Delacre M, Verdoux H, Moore N, Haramburu F, Miremont-Salame G, Etienne G, Robinson P, Gruson D, Hilbert G, Gabinski C, Begaud B, Molimard M (2007) Life-threatening adverse drug reactions at admission to medical intensive care: a prospective study in a teaching hospital. Intensive Care Med 33:2150–2157PubMedCrossRefGoogle Scholar
  42. 42.
    Pluess TT, Hayoz D, Berger MM, Tappy L, Revelly JP, Michaeli B, Carpentier YA, Chiolero RL (2007) Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects. Intensive Care Med 33:789–797PubMedCrossRefGoogle Scholar
  43. 43.
    Lam SW, Nguyen NQ, Ching K, Chapman M, Fraser RJ, Holloway RH (2007) Gastric feed intolerance is not increased in critically ill patients with type II diabetes mellitus. Intensive Care Med 33:1740–1745PubMedCrossRefGoogle Scholar
  44. 44.
    Kimball EJ, Mone MC, Wolfe TR, Baraghoshi GK, Alder SC (2007) Reproducibility of bladder pressure measurements in critically ill patients. Intensive Care Med 33:1195–1198PubMedCrossRefGoogle Scholar
  45. 45.
    De Laet I, Hoste E, Verholen E, De Waele JJ (2007) The effect of neuromuscular blockers in patients with intra-abdominal hypertension. Intensive Care Med 33:1811–1814PubMedCrossRefGoogle Scholar
  46. 46.
    Denz C, Siegel L, Lehmann KJ, Dagorn JC, Fiedler F (2007) Is hyperlipasemia in critically ill patients of clinical importance? An observational CT study. Intensive Care Med 33:1633–1636PubMedCrossRefGoogle Scholar
  47. 47.
    Van de Louw A, Lasserre N, Drouhin F, Thierry S, Lecuyer L, Caen D, Tenaillon A (2007) Reliability of HemoCue in patients with gastrointestinal bleeding. Intensive Care Med 33:355–358CrossRefGoogle Scholar
  48. 48.
    Jaecklin T, Morel DR, Rimensberger PC (2007) Volume-targeted modes of modern neonatal ventilators: how stable is the delivered tidal volume? Intensive Care Med 33:326–335PubMedCrossRefGoogle Scholar
  49. 49.
    Copnell B, Tingay DG, Kiraly NJ, Sourial M, Gordon MJ, Mills JF, Morley CJ, Dargaville PA (2007) A comparison of the effectiveness of open and closed endotracheal suction. Intensive Care Med 33:1655–1662PubMedCrossRefGoogle Scholar
  50. 50.
    Tingay DG, Copnell B, Mills JF, Morley CJ, Dargaville PA (2007) Effects of open endotracheal suction on lung volume in infants receiving HFOV. Intensive Care Med 33:689–693PubMedCrossRefGoogle Scholar
  51. 51.
    Duff JP, Rosychuk RJ, Joffe AR (2007) The safety and efficacy of sustained inflations as a lung recruitment maneuver in pediatric intensive care unit patients. Intensive Care Med 33:1778–1786PubMedCrossRefGoogle Scholar
  52. 52.
    von Ungern-Sternberg BS, Hammer J, Frei FJ, Jordi Ritz EM, Schibler A, Erb TO (2007) Prone equals prone? Impact of positioning techniques on respiratory function in anesthetized and paralyzed healthy children. Intensive Care Med 33:1771–1777CrossRefGoogle Scholar
  53. 53.
    Santschi M, Gauvin F, Hatzakis G, Lacroix J, Jouvet P (2007) Acceptable respiratory physiologic limits for children during weaning from mechanical ventilation. Intensive Care Med 33:319–325PubMedCrossRefGoogle Scholar
  54. 54.
    Bruijn M, van der Aa LB, van Rijn RR, Bos AP, van Woensel JB (2007) High incidence of acute lung injury in children with Down syndrome. Intensive Care Med 33:2179–2182PubMedCrossRefGoogle Scholar
  55. 55.
    Albert J, Harbut P, Zielinski S, Ryniak S, Gillis-Haegerstrand C, Lindwall R, Solski L, Lundberg JO, Svensson J, Gozdzik W (2007) Prolonged exposure to inhaled nitric oxide does not affect haemostasis in piglets. Intensive Care Med 33:1594–1601PubMedCrossRefGoogle Scholar
  56. 56.
    Fassassi M, Michel F, Thomachot L, Nicaise C, Vialet R, Jammes Y, Lagier P, Martin C (2007) Airway humidification with a heat and moisture exchanger in mechanically ventilated neonates : a preliminary evaluation. Intensive Care Med 33:336–343PubMedCrossRefGoogle Scholar
  57. 57.
    Bollen CW, Uiterwaal CS, van Vught AJ (2007) Meta-regression analysis of high-frequency ventilation vs. conventional ventilation in infant respiratory distress syndrome. Intensive Care Med 33:680–688PubMedCrossRefGoogle Scholar
  58. 58.
    Capoluongo E, Vento G, Rocchetti S, Giardina E, Concolino P, Sinibaldi C, Santonocito C, Vendettuoli V, Tana M, Tirone C, Zuppi C, Romagnoli C, Novelli G, Giardina B, Ameglio F (2007) Mannose-binding lectin polymorphisms and pulmonary outcome in premature neonates: a pilot study. Intensive Care Med 33:1787–1794PubMedCrossRefGoogle Scholar
  59. 59.
    Michalek J, Svetlikova P, Fedora M, Klimovic M, Klapacova L, Bartosova D, Elbl L, Hrstkova H, Hubacek JA (2007) Bactericidal permeability increasing protein gene variants in children with sepsis. Intensive Care Med 33:2158–2164PubMedCrossRefGoogle Scholar
  60. 60.
    Pavcnik-Arnol M, Hojker S, Derganc M (2007) Lipopolysaccharide-binding protein, lipopolysaccharide, and soluble CD14 in sepsis of critically ill neonates and children. Intensive Care Med 33:1025–1032PubMedCrossRefGoogle Scholar
  61. 61.
    Rey C, Los Arcos M, Concha A, Medina A, Prieto S, Martinez P, Prieto B (2007) Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children. Intensive Care Med 33:477–484PubMedCrossRefGoogle Scholar
  62. 62.
    Krueger M, Heinzmann A, Nauck M (2007) Adhesion molecules in pediatric intensive care patients with organ dysfunction syndrome. Intensive Care Med 33:359–363PubMedCrossRefGoogle Scholar
  63. 63.
    Callister ME, Burke-Gaffney A, Quinlan GJ, Betts H, Nadel S, Evans TW (2007) Persistently low plasma thioredoxin is associated with meningococcal septic shock in children. Intensive Care Med 33:364–367PubMedCrossRefGoogle Scholar
  64. 64.
    Staquet P, Lemee L, Verdier E, Bonmarchand G, Laudenbach V, Michel C, Lemeland JF, Marret S, Blanc T (2007) Detection of Neisseria meningitidis DNA from skin lesion biopsy using real-time PCR: usefulness in the aetiological diagnosis of purpura fulminans. Intensive Care Med 33:1168–1172PubMedCrossRefGoogle Scholar
  65. 65.
    Casartelli CH, Garcia PC, Branco RG, Piva JP, Einloft PR, Tasker RC (2007) Adrenal response in children with septic shock. Intensive Care Med 33:1609–1613PubMedCrossRefGoogle Scholar
  66. 66.
    Garcia-Teresa MA, Casado-Flores J, Delgado Dominguez MA, Roqueta-Mas J, Cambra-Lasaosa F, Concha-Torre A, Fernandez-Perez C (2007) Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study. Intensive Care Med 33:466–476PubMedCrossRefGoogle Scholar
  67. 67.
    Hatherill M, Salie S, Waggie Z, Lawrenson J, Hewitson J, Reynolds L, Argent A (2007) The lactate:pyruvate ratio following open cardiac surgery in children. Intensive Care Med 33:822–829PubMedCrossRefGoogle Scholar
  68. 68.
    Di Filippo S, Lai Y, Manrique A, Pigula F, Munoz R (2007) Intensive care course after stage 1 Norwood procedure: are there early predictors of failure? Intensive Care Med 33:111–119PubMedCrossRefGoogle Scholar
  69. 69.
    Bontadelli J, Moeller A, Schmugge M, Schraner T, Kretschmar O, Bauersfeld U, Bernet-Buettiker V, Albisetti M (2007) Enoxaparin therapy for arterial thrombosis in infants with congenital heart disease. Intensive Care Med 33:1978–1984PubMedCrossRefGoogle Scholar
  70. 70.
    Lemmer J, Stiller B, Heise G, Alexi-Meskishvili V, Hubler M, Weng Y, Berger F (2007) Mid-term follow-up in patients with diaphragmatic plication after surgery for congenital heart disease. Intensive Care Med 33:1985–1992PubMedCrossRefGoogle Scholar
  71. 71.
    Shankar V, Haque A, Churchwell KB, Russell W (2007) Insulin glargine supplementation during early management phase of diabetic ketoacidosis in children. Intensive Care Med 33:1173–1178PubMedCrossRefGoogle Scholar
  72. 72.
    Mehta NM, Halwick DR, Dodson BL, Thompson JE, Arnold JH (2007) Potential drug sequestration during extracorporeal membrane oxygenation: results from an ex vivo experiment. Intensive Care Med 33:1018–1024PubMedCrossRefGoogle Scholar
  73. 73.
    Kneyber MC, Hersi MI, Twisk JW, Markhorst DG, Plotz FB (2007) Red blood cell transfusion in critically ill children is independently associated with increased mortality. Intensive Care Med 33:1414–1422PubMedCrossRefGoogle Scholar
  74. 74.
    Kuzniewicz M, Draper D, Escobar GJ (2007) Incorporation of physiological trend and interaction effects in neonatal severity of illness scores: an experiment using a variant of the Richardson score. Intensive Care Med 33:1602–1608PubMedCrossRefGoogle Scholar
  75. 75.
    Wolfler A, Silvani P, Musicco M, Salvo I (2007) Pediatric Index of Mortality 2 score in Italy: a multicenter, prospective, observational study. Intensive Care Med 33:1407–1413PubMedCrossRefGoogle Scholar
  76. 76.
    Schieveld JN, Leroy PL, van Os J, Nicolai J, Vos GD, Leentjens AF (2007) Pediatric delirium in critical illness: phenomenology, clinical correlates and treatment response in 40 cases in the pediatric intensive care unit. Intensive Care Med 33:1033–1040PubMedCrossRefGoogle Scholar
  77. 77.
    Cheung CL, van Dijk M, Green JW, Tibboel D, Anand KJ (2007) Effects of low-dose naloxone on opioid therapy in pediatric patients: a retrospective case–control study. Intensive Care Med 33:190–194PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Massimo Antonelli
    • 1
    Email author
  • Elie Azoulay
    • 2
  • Marc Bonten
    • 3
  • Jean Chastre
    • 4
  • Giuseppe Citerio
    • 5
  • Giorgio Conti
    • 6
  • Daniel De Backer
    • 7
  • François Lemaire
    • 8
  • Herwig Gerlach
    • 9
  • Johan Groeneveld
    • 10
  • Goran Hedenstierna
    • 11
  • Duncan Macrae
    • 12
  • Jordi Mancebo
    • 13
  • Salvatore M. Maggiore
    • 6
  • Alexandre Mebazaa
    • 14
  • Philipp Metnitz
    • 15
  • Jerôme Pugin
    • 16
  • Jan Wernerman
    • 17
  • Haibo Zhang
    • 18
  1. 1.Department of Intensive Care and Anesthesiology, Policlinico Universitario A. GemelliUniversità Cattolica del Sacro CuoreRomeItaly
  2. 2.Intensive Care Medicine UnitSaint Louis HospitalParisFrance
  3. 3.Department of Medical Microbiology Julius Center for Health Sciences & Primary CareUniversity Medical Center UtrechtUtrechtThe Netherlands
  4. 4.Reanimation medicaleHopital Pitié SalpétrièreParisFrance
  5. 5.Neurointensive Care UnitOspedale S. GerardoMonzaItaly
  6. 6.Department of Intensive Care and AnesthesiologyUniversità Cattolica del Sacro CuoreRomeItaly
  7. 7.Service des Soins IntensifsErasme HospitalBrusselsBelgium
  8. 8.Intensive Care UnitHenri Mondor HospitalCreteilFrance
  9. 9.Department of AnesthesiologyVivantes-Klinikum NeukoellnBerlinGermany
  10. 10.Intensive Care Medicine UnitVUMCAmsterdamThe Netherlands
  11. 11.Department of Clinical PhysiologyUppsala UniversityUppsalaSweden
  12. 12.Pediatric Intensive Care UnitRoyal Brompton HospitalLondonUK
  13. 13.Intensive Care Medicine UnitHospital Sant PauBarcelonaSpain
  14. 14.Department of Anesthesiology and Critical Care MedicineLariboisière HospitalParisFrance
  15. 15.Department of Anesthesia and General Intensive Care MedicineUniversity Hospital of ViennaViennaAustria
  16. 16.Intensive Care Medicine UnitUniversity Hospital of GenevaGenevaSwitzerland
  17. 17.Departments of Anesthesiology and Intensive Care MedicineKarolinska University HospitalStockholmSweden
  18. 18.Interdepartmental Division of Critical Care MedicineUniversity of TorontoTorontoCanada

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