Intensive Care Medicine

, Volume 33, Issue 7, pp 1243–1251

Alveolar epithelium and Na,K-ATPase in acute lung injury

Mini-series: basic research-related topics in ICM

DOI: 10.1007/s00134-007-0661-8

Cite this article as:
Vadász, I., Raviv, S. & Sznajder, J.I. Intensive Care Med (2007) 33: 1243. doi:10.1007/s00134-007-0661-8

Abstract

Active transport of sodium across the alveolar epithelium, undertaken in part by the Na,K-adenosine triphosphatase (Na,K-ATPase), is critical for clearance of pulmonary edema fluid and thus the outcome of patients with acute lung injury. Acute lung injury results in disruption of the alveolar epithelial barrier and leads to impaired clearance of edema fluid and altered Na,K-ATPase function. There has been significant progress in the understanding of mechanisms regulating alveolar edema clearance and signaling pathways modulating Na,K-ATPase function during lung injury. The accompanying review by Morty et al. focuses on intact organ and animal models as well as clinical studies assessing alveolar fluid reabsorption in alveolar epithelial injury. Elucidation of the mechanisms underlying regulation of active Na+ transport, as well as the pathways by which the Na,K-ATPase regulates epithelial barrier function and edema clearance, are of significance to identify interventional targets to improve outcomes of patients with acute lung injury.

Keywords

Edema clearance Hypoxia Coagulation Catecholamines Dopamine Protein trafficking 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • István Vadász
    • 1
  • Stacy Raviv
    • 1
  • Jacob I. Sznajder
    • 1
  1. 1.Division of Pulmonary and Critical Care MedicineFeinberg School of Medicine, Northwestern UniversityChicagoUSA

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