Intensive Care Medicine

, 33:1533 | Cite as

De-escalation therapy rates are significantly higher by bronchoalveolar lavage than by tracheal aspirate

  • Elpis Giantsou
  • Nikolaos Liratzopoulos
  • Eleni Efraimidou
  • Maria Panopoulou
  • Eleonora Alepopoulou
  • Sofia Kartali-Ktenidou
  • Konstantinos Manolas



To assess outcomes with de-escalation therapy in ventilator-associated pneumonia (VAP).


Prospective observational study.


Multidisciplinary intensive care unit.

Patients and participants

VAP was diagnosed by positive quantitative cultures of both tracheal aspirate and bronchoalveolar lavage (BAL) and treated appropriately for all significant isolates of tracheal aspirate and BAL in 143 patients who were assigned to de-escalation therapy by BAL or tracheal aspirate.



Measurements and results

Antibiotic therapy was de-escalated in 58 patients (40.5%), who had decreased mortality at day 15 (5.1% vs. 31.7%) and day 28 (12% vs. 43.5%) and shorter intensive care unit (17.2 ± 1.2 vs. 22.7 ± 6.3 days) and hospital (23.7 ± 2.8 vs. 29.8 ± 11.1 days) stay (p < 0.05). Of the 81 patients assigned to tracheal aspirate, the 17 (21%) who achieved de-escalation of therapy had reduced 15-day mortality (5.8% vs. 34.3%), reduced 28-day mortality (11.6% vs. 45.3%), and shorter intensive care unit (17.2 ± 1.6 vs. 22.4 ± 6.4 days) and hospital (23.1 ± 4.4 vs. 29.9 ± 11.1 days) stay (p < 0.05). Of the 62 patients assigned to BAL, the 41 (66.1%) who achieved de-escalation of therapy had decreased 15-day mortality (4.8% vs. 23.8%), decreased 28-day mortality (12.1% vs. 38%), and shorter intensive care unit (17.2 ± 1.1 vs. 23.2 ± 6 days) and hospital (23.8 ± 2.4 vs. 29.8 ± 11.4 days) stay (p < 0.05).


For patients with VAP who have had appropriate treatment and shown a favorable clinical response, mortality and duration of stay can be further improved by de-escalation therapy.


De-escalation therapy Ventilator-associated pneumonia 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Elpis Giantsou
    • 1
    • 3
  • Nikolaos Liratzopoulos
    • 1
  • Eleni Efraimidou
    • 1
  • Maria Panopoulou
    • 2
  • Eleonora Alepopoulou
    • 2
  • Sofia Kartali-Ktenidou
    • 2
  • Konstantinos Manolas
    • 1
  1. 1.Intensive Care Unit, Department of Surgery, Medical SchoolDemokritus University of ThraceAlexandropolisGreece
  2. 2.Department of Microbiology Medical SchoolDemokritus University of ThraceAlexandropolisGreece
  3. 3.Electras 10AthensGreece

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