Intensive Care Medicine

, Volume 33, Issue 6, pp 993–999 | Cite as

Plethysmographic dynamic indices predict fluid responsiveness in septic ventilated patients

  • Marc Feissel
  • Jean-Louis Teboul
  • Paolo Merlani
  • Julio Badie
  • Jean-Pierre Faller
  • Karim BendjelidEmail author



In septic patients, reliable non-invasive predictors of fluid responsiveness are needed. We hypothesised that the respiratory changes in the amplitude of the plethysmographic pulse wave (ΔPPLET) would allow the prediction of changes in cardiac index following volume administration in mechanically ventilated septic patients.


Prospective clinical investigation.


An 11-bed hospital medical intensive care unit.


Twenty-three deeply sedated septic patients mechanically ventilated with tidal volume ≥ 8 ml/kg and equipped with an arterial catheter and a pulse oximetry plethysmographic sensor.


Respiratory changes in pulse pressure (ΔPP), ΔPPLET and cardiac index (transthoracic Doppler echocardiography) were determined before and after volume infusion of colloids (8 ml/kg).

Measurements and main results

Twenty-eight volume challenges were performed in 23 patients. Before volume expansion, ΔPP correlated with ΔPPLET (r 2 = 0.71, p < 0.001). Changes in cardiac index after volume expansion significantly (p < 0.001) correlated with baseline ΔPP (r 2 = 0.76) and ΔPPLET (r 2 = 0.50). The patients were defined as responders to fluid challenge when cardiac index increased by at least 15% after the fluid challenge. Such an event occurred 18 times. Before volume challenge, a ΔPP value of 12% and a ΔPPLET value of 14% allowed discrimination between responders and non-responders with sensitivity of 100% and 94% respectively and specificity of 70% and 80% respectively. Comparison of areas under the receiver operator characteristic curves showed that ΔPP and ΔPPLET predicted similarly fluid responsiveness.


The present study found ΔPPLET to be as accurate as ΔPP for predicting fluid responsiveness in mechanically ventilated septic patients.


Fluid resuscitation Heart–lung interactions Volume responsiveness Monitoring 

Supplementary material

134_2007_602_MOESM1_ESM.doc (43 kb)
Electronic Supplementary Material (DOC 42K)


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Marc Feissel
    • 1
  • Jean-Louis Teboul
    • 2
  • Paolo Merlani
    • 3
  • Julio Badie
    • 1
  • Jean-Pierre Faller
    • 1
  • Karim Bendjelid
    • 3
    Email author
  1. 1.Intensive Care UnitCentre HospitalierBelfortFrance
  2. 2.Réanimation médicale, Bicêtre HospitalParis Sud Medical SchoolLe Kremlin BicêtreFrance
  3. 3.Intensive Care Unit, Department of Anesthesiology, Pharmacology and Intensive CareGeneva University HospitalsGeneva 14Switzerland

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