Intensive Care Medicine

, Volume 33, Issue 1, pp 163–171 | Cite as

Increased intra-abdominal pressure affects respiratory variations in arterial pressure in normovolaemic and hypovolaemic mechanically ventilated healthy pigs

  • Serge Duperret
  • Franck Lhuillier
  • Vincent Piriou
  • Emmanuel Vivier
  • Olivier Metton
  • Patricia Branche
  • Guy Annat
  • Karim Bendjelid
  • Jean Paul Viale



To evaluate the effect of increased intra-abdominal pressure (IAP) on the systolic and pulse pressure variations induced by positive pressure ventilation in a porcine model.

Design and setting

Experimental study in a research laboratory.


Seven mechanically ventilated and instrumented pigs prone to normovolaemia and hypovolaemia by blood withdrawal.


Abdominal banding gradually increased IAP in 5-mmHg steps up to 30 mmHg.

Measurements and main results

Variations in systolic pressure, pulse pressure, inferior vena cava flow, and pleural and transmural (LVEDPtm) left-ventricular end-diastolic pressure were recorded at each step. Systolic pressure variations were 6.1 ± 3.1%, 8.5 ± 3.6% and 16.0 ± 5.0% at 0, 10, and 30 mmHg IAP in normovolaemic animals (mean ± SD; p< 0.01 for IAP effect). They were 12.7 ± 4.6%, 13.4 ± 6.7%, and 23.4 ± 6.3% in hypovolaemic animals (p< 0.01 vs normovolaemic group) for the same IAP. Fluctuations of the inferior vena cava flow disappeared as the IAP increased. Breath cycle did not induce any variations of LVEDPtm for 0 and 30 mmHg IAP.


In this model, the systolic pressure and pulse pressure variations, and inferior vena cava flow fluctuations were dependent on IAP values which caused changes in pleural pressure swing, and this dependency was more marked during hypovolaemia. The present study suggests that dynamic indices are not exclusively related to volaemia in the presence of increased IAP. However, their fluid responsiveness predictive value could not be ascertained as no fluid challenge was performed.


Intra-abdominal hypertension Systolic pressure variations Echocardiography 



The authors thank Florence Arnal and Sylviane Conti, research technicians, UPRES EA 1896, Faculté de médecine, Rockefeller, Lyon, France for excellent technical assistance, and A. Vieillard Baron for his helpful comments.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Serge Duperret
    • 1
  • Franck Lhuillier
    • 1
  • Vincent Piriou
    • 2
  • Emmanuel Vivier
    • 1
  • Olivier Metton
    • 3
  • Patricia Branche
    • 1
  • Guy Annat
    • 4
  • Karim Bendjelid
    • 5
  • Jean Paul Viale
    • 4
  1. 1.Department of Anaesthesiology and Intensive CareHôpital de la Croix-RousseLyonFrance
  2. 2.Department of Anaesthesiology and Intensive CareHôpital Lyon SudLyonFrance
  3. 3.Department of SurgeryHôpital Cardio-vasculaire Louis PradelBronFrance
  4. 4.Laboratoire de Physiologie de l’EnvironnementFaculté de médecineLyonFrance
  5. 5.Department of AnaesthesiologyGeneva University HospitalGenevaSwitzerland

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